3 recherche sur le mot-clé 'regressive autism'

Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study / Alana IABONI ; Brett TROST ; Miriam REUTER ; Zsuzsa LINDENMAIER ; Azadeh KUSHKI ; Elizabeth KELLEY ; Jessica JONES ; Muhammad AYUB ; Stelios GEORGIADES ; Robert NICOLSON ; Elim CHAN ; Andrada CRETU ; Jessica BRIAN ; Evdokia ANAGNOSTOU in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1290-1300 Titre : Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study Type de document : texte imprimé Auteurs : Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammad AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1290-1300 Langues : Anglais (eng) Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected 0.015) and adaptive function (ABAS-2) scores (p corrected 0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p 0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study [texte imprimé] / Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammad AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1290-1300. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1290-1300 Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected 0.015) and adaptive function (ABAS-2) scores (p corrected 0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p 0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts / Lucy THOMPSON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290 Titre : Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts Type de document : texte imprimé Auteurs : Lucy THOMPSON, Auteur ; Christopher GILLBERG, Auteur ; Sara LANDBERG, Auteur ; Anne-Katrin KANTZER, Auteur ; Carmela MINISCALCO, Auteur ; Martina BARNEVIK OLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Elisabeth FERNELL, Auteur Article en page(s) : p.2281-2290 Langues : Anglais (eng) Mots-clés : Asd  Autism  Developmental language disorder  Intellectual developmental disorder  Non-regressive autism  Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts [texte imprimé] / Lucy THOMPSON, Auteur ; Christopher GILLBERG, Auteur ; Sara LANDBERG, Auteur ; Anne-Katrin KANTZER, Auteur ; Carmela MINISCALCO, Auteur ; Martina BARNEVIK OLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Elisabeth FERNELL, Auteur . - p.2281-2290. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290 Mots-clés : Asd  Autism  Developmental language disorder  Intellectual developmental disorder  Non-regressive autism  Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Gut Microbiota and Autism: Key Concepts and Findings / Helen T. DING in Journal of Autism and Developmental Disorders, 47-2 (February 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-2 (February 2017) . - p.480-489 Titre : Gut Microbiota and Autism: Key Concepts and Findings Type de document : texte imprimé Auteurs : Helen T. DING, Auteur ; Ying TAUR, Auteur ; John T. WALKUP, Auteur Article en page(s) : p.480-489 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder (ASD)  Regressive autism  Gastrointestinal symptoms  Microbiota  Microbiome Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-016-2960-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Gut Microbiota and Autism: Key Concepts and Findings [texte imprimé] / Helen T. DING, Auteur ; Ying TAUR, Auteur ; John T. WALKUP, Auteur . - p.480-489. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-2 (February 2017) . - p.480-489 Mots-clés : Autism  Autism spectrum disorder (ASD)  Regressive autism  Gastrointestinal symptoms  Microbiota  Microbiome Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-016-2960-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303