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Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome / J. C. HUSTON in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
[article]
Titre : Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. C. HUSTON, Auteur ; R. P. THOM, Auteur ; C. T. RAVICHANDRAN, Auteur ; J. E. MULLETT, Auteur ; C. MORAN, Auteur ; Jessica L. WAXLER, Auteur ; B. R. POBER, Auteur ; C. J. MCDOUGLE, Auteur Article en page(s) : p.852-862 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Female Humans Male Obsessive Behavior/diagnosis Obsessive-Compulsive Disorder/diagnosis/epidemiology Psychiatric Status Rating Scales Severity of Illness Index Tics Williams Syndrome Compulsion Obsession Repetitive Stereotypy Tic Williams syndrome Index. décimale : PER Périodiques Résumé : The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale-Parent Version. Nineteen males and 41 females participated in the study. Six subjects (10%) had obsessions only, six (10%) had compulsions only, and eleven (18%) had at least one obsession and at least one compulsion. None of the subjects had tics. Fifty subjects (83.3%) endorsed at least one stereotypy. Increased anxiety was associated with increased severity of obsessions, but not severity of compulsions or stereotypies. En ligne : http://dx.doi.org/10.1007/s10803-021-04979-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.852-862[article] Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome [Texte imprimé et/ou numérique] / J. C. HUSTON, Auteur ; R. P. THOM, Auteur ; C. T. RAVICHANDRAN, Auteur ; J. E. MULLETT, Auteur ; C. MORAN, Auteur ; Jessica L. WAXLER, Auteur ; B. R. POBER, Auteur ; C. J. MCDOUGLE, Auteur . - p.852-862.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.852-862
Mots-clés : Autism Spectrum Disorder Child Female Humans Male Obsessive Behavior/diagnosis Obsessive-Compulsive Disorder/diagnosis/epidemiology Psychiatric Status Rating Scales Severity of Illness Index Tics Williams Syndrome Compulsion Obsession Repetitive Stereotypy Tic Williams syndrome Index. décimale : PER Périodiques Résumé : The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale-Parent Version. Nineteen males and 41 females participated in the study. Six subjects (10%) had obsessions only, six (10%) had compulsions only, and eleven (18%) had at least one obsession and at least one compulsion. None of the subjects had tics. Fifty subjects (83.3%) endorsed at least one stereotypy. Increased anxiety was associated with increased severity of obsessions, but not severity of compulsions or stereotypies. En ligne : http://dx.doi.org/10.1007/s10803-021-04979-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Non-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised / V. COURCHESNE in Molecular Autism, 12 (2021)
[article]
Titre : Non-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised Type de document : Texte imprimé et/ou numérique Auteurs : V. COURCHESNE, Auteur ; Rachael BEDFORD, Auteur ; A. PICKLES, Auteur ; E. DUKU, Auteur ; Connor M. KERNS, Auteur ; P. MIRENDA, Auteur ; Teresa BENNETT, Auteur ; S. GEORGIADES, Auteur ; I. M. SMITH, Auteur ; W. J. UNGAR, Auteur ; T. VAILLANCOURT, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; P. SZATMARI, Auteur ; M. ELSABBAGH, Auteur Article en page(s) : 57 p. Langues : Anglais (eng) Mots-clés : Adi-r Autism Behaviors Intelligence Interest Longitudinal Repetitive Restricted Wechsler Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behavior (RRB) is one of the characteristic features of Autism Spectrum Disorder. This domain of symptoms includes a broad range of behaviors. There is a need to study each behavior individually to better understand the role of each in the development of autistic children. Moreover, there are currently no longitudinal studies investigating change in these behaviors over development. METHODS: The goal of the present study was to explore the association between age and non-verbal IQ (NVIQ) on 15 RRB symptoms included in the Autism Diagnostic Interview-Revised (ADI-R) over time. A total of 205 children with ASD were assessed using the ADI-R at time of diagnosis, at age 6 years, and at age 11 years, and with the Wechsler Intelligence Scales for Children-Fourth Edition (WISC-IV) at age 8 years. RESULTS: The proportion of children showing each RRB tended to diminish with increasing age, except for sensitivity to noise and circumscribed interests, where the proportion increased over time. Although there was no significant main effect of NVIQ, there was a significant interaction between age and NVIQ. This was mainly driven by Difficulties with change in routine, for which higher NVIQ was associated with the behavior remaining relatively stable with age, while lower NVIQ was associated with the behavior becoming more prevalent with age. LIMITATIONS: The study focused on the presence/absence of each RRB but did not account for potential changes in frequency or severity of the behaviors over development. Furthermore, some limitations are inherent to the measures used. The ADI-R relies on parent report and hence has some level of subjectivity, while the Wechsler intelligence scales can underestimate the intellectual abilities of some autistic children. CONCLUSIONS: These results confirm that specific RRB are differentially linked to age and NVIQ. Studying RRB individually is a promising approach to better understanding how RRB change over the development of autistic children and are linked to other developmental domains. En ligne : http://dx.doi.org/10.1186/s13229-021-00461-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 57 p.[article] Non-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised [Texte imprimé et/ou numérique] / V. COURCHESNE, Auteur ; Rachael BEDFORD, Auteur ; A. PICKLES, Auteur ; E. DUKU, Auteur ; Connor M. KERNS, Auteur ; P. MIRENDA, Auteur ; Teresa BENNETT, Auteur ; S. GEORGIADES, Auteur ; I. M. SMITH, Auteur ; W. J. UNGAR, Auteur ; T. VAILLANCOURT, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; P. SZATMARI, Auteur ; M. ELSABBAGH, Auteur . - 57 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 57 p.
Mots-clés : Adi-r Autism Behaviors Intelligence Interest Longitudinal Repetitive Restricted Wechsler Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behavior (RRB) is one of the characteristic features of Autism Spectrum Disorder. This domain of symptoms includes a broad range of behaviors. There is a need to study each behavior individually to better understand the role of each in the development of autistic children. Moreover, there are currently no longitudinal studies investigating change in these behaviors over development. METHODS: The goal of the present study was to explore the association between age and non-verbal IQ (NVIQ) on 15 RRB symptoms included in the Autism Diagnostic Interview-Revised (ADI-R) over time. A total of 205 children with ASD were assessed using the ADI-R at time of diagnosis, at age 6 years, and at age 11 years, and with the Wechsler Intelligence Scales for Children-Fourth Edition (WISC-IV) at age 8 years. RESULTS: The proportion of children showing each RRB tended to diminish with increasing age, except for sensitivity to noise and circumscribed interests, where the proportion increased over time. Although there was no significant main effect of NVIQ, there was a significant interaction between age and NVIQ. This was mainly driven by Difficulties with change in routine, for which higher NVIQ was associated with the behavior remaining relatively stable with age, while lower NVIQ was associated with the behavior becoming more prevalent with age. LIMITATIONS: The study focused on the presence/absence of each RRB but did not account for potential changes in frequency or severity of the behaviors over development. Furthermore, some limitations are inherent to the measures used. The ADI-R relies on parent report and hence has some level of subjectivity, while the Wechsler intelligence scales can underestimate the intellectual abilities of some autistic children. CONCLUSIONS: These results confirm that specific RRB are differentially linked to age and NVIQ. Studying RRB individually is a promising approach to better understanding how RRB change over the development of autistic children and are linked to other developmental domains. En ligne : http://dx.doi.org/10.1186/s13229-021-00461-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Promoting Behavioral Variability in Individuals With Autism Spectrum Disorders: A Literature Review / Katie WOLFE in Focus on Autism and Other Developmental Disabilities, 29-3 (September 2014)
[article]
Titre : Promoting Behavioral Variability in Individuals With Autism Spectrum Disorders: A Literature Review Type de document : Texte imprimé et/ou numérique Auteurs : Katie WOLFE, Auteur ; Timothy A. SLOCUM, Auteur ; S. Shanun KUNNAVATANA, Auteur Article en page(s) : p.180-190 Langues : Anglais (eng) Mots-clés : autism repetitive response diversity response variation variability Index. décimale : PER Périodiques Résumé : Repetitive behavior is a hallmark feature of autism spectrum disorders (ASD), and can have adverse consequences related to social stigma and low rates of skill acquisition. Basic research suggests that variability, or the extent to which one response differs from previous responses, is amenable to antecedent and consequence manipulations. This article describes the concept of variability, synthesizes the findings of 14 recent studies on interventions to increase the variability of behavior in individuals with ASD, and proposes preliminary guidelines for practitioners that focus on building response repertoires, implementing contingencies to produce and maintain variability, and incorporating prompts to vary responding. En ligne : http://dx.doi.org/10.1177/1088357614525661 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Focus on Autism and Other Developmental Disabilities > 29-3 (September 2014) . - p.180-190[article] Promoting Behavioral Variability in Individuals With Autism Spectrum Disorders: A Literature Review [Texte imprimé et/ou numérique] / Katie WOLFE, Auteur ; Timothy A. SLOCUM, Auteur ; S. Shanun KUNNAVATANA, Auteur . - p.180-190.
Langues : Anglais (eng)
in Focus on Autism and Other Developmental Disabilities > 29-3 (September 2014) . - p.180-190
Mots-clés : autism repetitive response diversity response variation variability Index. décimale : PER Périodiques Résumé : Repetitive behavior is a hallmark feature of autism spectrum disorders (ASD), and can have adverse consequences related to social stigma and low rates of skill acquisition. Basic research suggests that variability, or the extent to which one response differs from previous responses, is amenable to antecedent and consequence manipulations. This article describes the concept of variability, synthesizes the findings of 14 recent studies on interventions to increase the variability of behavior in individuals with ASD, and proposes preliminary guidelines for practitioners that focus on building response repertoires, implementing contingencies to produce and maintain variability, and incorporating prompts to vary responding. En ligne : http://dx.doi.org/10.1177/1088357614525661 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism / M. A. RHINE in Autism Research, 12-3 (March 2019)
[article]
Titre : Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism Type de document : Texte imprimé et/ou numérique Auteurs : M. A. RHINE, Auteur ; J. M. PARROTT, Auteur ; M. N. SCHULTZ, Auteur ; T. M. KAZDOBA, Auteur ; J. N. CRAWLEY, Auteur Article en page(s) : p.401-421 Langues : Anglais (eng) Mots-clés : Gaba Trkb autism cognitive medicine mice preclinical repetitive social Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA-approved medical treatments exist for the diagnostic symptoms of autism. Here we interrogate multiple pharmacological targets in two distinct mouse models that incorporate well-replicated autism-relevant behavioral phenotypes. Compounds that modify inhibitory or excitatory neurotransmission were selected to address hypotheses based on previously published biological abnormalities in each model. Shank3B is a genetic model of a mutation found in autism and Phelan-McDermid syndrome, in which deficits in excitatory neurotransmission and synaptic plasticity have been reported. BTBR is an inbred strain model of forms of idiopathic autism in which reduced inhibitory neurotransmission and excessive mTOR signaling have been reported. The GABA-A receptor agonist gaboxadol significantly reduced repetitive self-grooming in three independent cohorts of BTBR. The TrkB receptor agonist 7,8-DHF improved spatial learning in Shank3B mice, and reversed aspects of social deficits in BTBR. CX546, a positive allosteric modulator of the glutamatergic AMPA receptor, and d-cycloserine, a partial agonist of the glycine site on the glutamatergic NMDA receptor, did not rescue aberrant behaviors in Shank3B mice. The mTOR inhibitor rapamycin did not ameliorate social deficits or repetitive behavior in BTBR mice. Comparison of positive and negative pharmacological outcomes, on multiple phenotypes, evaluated for replicability across independent cohorts, enhances the translational value of mouse models of autism for therapeutic discovery. GABA agonists present opportunities for personalized interventions to treat components of autism spectrum disorder. Autism Res 2019, 12: 401-421 (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Many of the risk genes for autism impair synapses, the connections between nerve cells in the brain. A drug that reverses the synaptic effects of a mutation could offer a precision therapy. Combining pharmacological and behavioral therapies could reduce symptoms and improve the quality of life for people with autism. Here we report reductions in repetitive behavior by a GABA-A receptor agonist, gaboxadol, and improvements in social and cognitive behaviors by a TrkB receptor agonist, in mouse models of autism. En ligne : http://dx.doi.org/10.1002/aur.2066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387
in Autism Research > 12-3 (March 2019) . - p.401-421[article] Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism [Texte imprimé et/ou numérique] / M. A. RHINE, Auteur ; J. M. PARROTT, Auteur ; M. N. SCHULTZ, Auteur ; T. M. KAZDOBA, Auteur ; J. N. CRAWLEY, Auteur . - p.401-421.
Langues : Anglais (eng)
in Autism Research > 12-3 (March 2019) . - p.401-421
Mots-clés : Gaba Trkb autism cognitive medicine mice preclinical repetitive social Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA-approved medical treatments exist for the diagnostic symptoms of autism. Here we interrogate multiple pharmacological targets in two distinct mouse models that incorporate well-replicated autism-relevant behavioral phenotypes. Compounds that modify inhibitory or excitatory neurotransmission were selected to address hypotheses based on previously published biological abnormalities in each model. Shank3B is a genetic model of a mutation found in autism and Phelan-McDermid syndrome, in which deficits in excitatory neurotransmission and synaptic plasticity have been reported. BTBR is an inbred strain model of forms of idiopathic autism in which reduced inhibitory neurotransmission and excessive mTOR signaling have been reported. The GABA-A receptor agonist gaboxadol significantly reduced repetitive self-grooming in three independent cohorts of BTBR. The TrkB receptor agonist 7,8-DHF improved spatial learning in Shank3B mice, and reversed aspects of social deficits in BTBR. CX546, a positive allosteric modulator of the glutamatergic AMPA receptor, and d-cycloserine, a partial agonist of the glycine site on the glutamatergic NMDA receptor, did not rescue aberrant behaviors in Shank3B mice. The mTOR inhibitor rapamycin did not ameliorate social deficits or repetitive behavior in BTBR mice. Comparison of positive and negative pharmacological outcomes, on multiple phenotypes, evaluated for replicability across independent cohorts, enhances the translational value of mouse models of autism for therapeutic discovery. GABA agonists present opportunities for personalized interventions to treat components of autism spectrum disorder. Autism Res 2019, 12: 401-421 (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Many of the risk genes for autism impair synapses, the connections between nerve cells in the brain. A drug that reverses the synaptic effects of a mutation could offer a precision therapy. Combining pharmacological and behavioral therapies could reduce symptoms and improve the quality of life for people with autism. Here we report reductions in repetitive behavior by a GABA-A receptor agonist, gaboxadol, and improvements in social and cognitive behaviors by a TrkB receptor agonist, in mouse models of autism. En ligne : http://dx.doi.org/10.1002/aur.2066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 The Survey of Favorite Interests and Activities: Assessing and understanding restricted interests in children with autism spectrum disorder / A. SMERBECK in Autism, 23-1 (January 2019)
[article]
Titre : The Survey of Favorite Interests and Activities: Assessing and understanding restricted interests in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. SMERBECK, Auteur Article en page(s) : p.247-259 Langues : Anglais (eng) Mots-clés : Asperger's autism spectrum disorder circumscribed interests restricted and repetitive behavior restricted interests exploratory factor-analysis high-functioning autism repetitive behavior asperger-syndrome parallel analysis individuals youth validation disability Psychology Index. décimale : PER Périodiques Résumé : Restricted interests are an established diagnostic symptom of autism spectrum disorder. While there is considerable evidence that these interests have maladaptive consequences, they also provide a range of benefits. This article introduces a new instrument, the Survey of Favorite Interests and Activities, and uses it to examine the nature of restricted interests in autism spectrum disorder. Respondents report substantial benefits of restricted interests as well as areas of difficulty. The Survey of Favorite Interests and Activities assesses Social Flexibility, Perseveration, Respondent Discomfort, Adaptive Coping, and Atypicality. All scales have Cronbach's alpha > 0.70. Age and socioeconomic status have little effect on Survey of Favorite Interests and Activities scales; nor does gender with the exception of interest Atypicality. The expected pattern of correlations with existing scales was found. Research and clinical implications are discussed. En ligne : http://dx.doi.org/10.1177/1362361317742140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379
in Autism > 23-1 (January 2019) . - p.247-259[article] The Survey of Favorite Interests and Activities: Assessing and understanding restricted interests in children with autism spectrum disorder [Texte imprimé et/ou numérique] / A. SMERBECK, Auteur . - p.247-259.
Langues : Anglais (eng)
in Autism > 23-1 (January 2019) . - p.247-259
Mots-clés : Asperger's autism spectrum disorder circumscribed interests restricted and repetitive behavior restricted interests exploratory factor-analysis high-functioning autism repetitive behavior asperger-syndrome parallel analysis individuals youth validation disability Psychology Index. décimale : PER Périodiques Résumé : Restricted interests are an established diagnostic symptom of autism spectrum disorder. While there is considerable evidence that these interests have maladaptive consequences, they also provide a range of benefits. This article introduces a new instrument, the Survey of Favorite Interests and Activities, and uses it to examine the nature of restricted interests in autism spectrum disorder. Respondents report substantial benefits of restricted interests as well as areas of difficulty. The Survey of Favorite Interests and Activities assesses Social Flexibility, Perseveration, Respondent Discomfort, Adaptive Coping, and Atypicality. All scales have Cronbach's alpha > 0.70. Age and socioeconomic status have little effect on Survey of Favorite Interests and Activities scales; nor does gender with the exception of interest Atypicality. The expected pattern of correlations with existing scales was found. Research and clinical implications are discussed. En ligne : http://dx.doi.org/10.1177/1362361317742140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379