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5 recherche sur le mot-clé 'resting state fMRI'
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Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism / R. TUNG in Autism Research, 14-10 (October 2021)
[article]
Titre : Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism Type de document : Texte imprimé et/ou numérique Auteurs : R. TUNG, Auteur ; M. A. REITER, Auteur ; A. LINKE, Auteur ; J. S. KOHLI, Auteur ; M. K. KINNEAR, Auteur ; R. A. MULLER, Auteur ; Ruth A. CARPER, Auteur Article en page(s) : p.2100-2112 Langues : Anglais (eng) Mots-clés : Adult Anxiety/complications/diagnostic imaging Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder/complications/diagnostic imaging Brain/diagnostic imaging Brain Mapping Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways/diagnostic imaging Asd adults anxiety autism functional connectivity resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64?years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q?0.1 (corrected) and p?0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-10 (October 2021) . - p.2100-2112[article] Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism [Texte imprimé et/ou numérique] / R. TUNG, Auteur ; M. A. REITER, Auteur ; A. LINKE, Auteur ; J. S. KOHLI, Auteur ; M. K. KINNEAR, Auteur ; R. A. MULLER, Auteur ; Ruth A. CARPER, Auteur . - p.2100-2112.
Langues : Anglais (eng)
in Autism Research > 14-10 (October 2021) . - p.2100-2112
Mots-clés : Adult Anxiety/complications/diagnostic imaging Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder/complications/diagnostic imaging Brain/diagnostic imaging Brain Mapping Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways/diagnostic imaging Asd adults anxiety autism functional connectivity resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64?years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q?0.1 (corrected) and p?0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood / E. DE WATER in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)
[article]
Titre : A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood Type de document : Texte imprimé et/ou numérique Auteurs : E. DE WATER, Auteur ; P. CURTIN, Auteur ; A. ZILVERSTAND, Auteur ; A. SJODIN, Auteur ; A. BONILLA, Auteur ; J. B. HERBSTMAN, Auteur ; J. RAMIREZ, Auteur ; A. E. MARGOLIS, Auteur ; R. BANSAL, Auteur ; R. M. WHYATT, Auteur ; B. S. PETERSON, Auteur ; P. FACTOR-LITVAK, Auteur ; M. K. HORTON, Auteur Article en page(s) : p.1010-1020 Langues : Anglais (eng) Mots-clés : Children executive functioning flame retardants pregnancy resting state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS: In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. RESULTS: Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's = .05); (b) more reported EF problems (beta's = .001, FDR-corrected p's = .05). Higher global efficiency of brain areas involved in visual attention was associated with more EF problems (beta's = .01, FDR-corrected p's < .05). CONCLUSIONS: Intrinsic functional network organization of visual attention brain areas linked prenatal PBDE concentrations to EF problems in childhood. Visual attention may contribute to the development of higher-order cognitive functions, such as EF, which could be explored in future studies. En ligne : http://dx.doi.org/10.1111/jcpp.13040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.1010-1020[article] A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood [Texte imprimé et/ou numérique] / E. DE WATER, Auteur ; P. CURTIN, Auteur ; A. ZILVERSTAND, Auteur ; A. SJODIN, Auteur ; A. BONILLA, Auteur ; J. B. HERBSTMAN, Auteur ; J. RAMIREZ, Auteur ; A. E. MARGOLIS, Auteur ; R. BANSAL, Auteur ; R. M. WHYATT, Auteur ; B. S. PETERSON, Auteur ; P. FACTOR-LITVAK, Auteur ; M. K. HORTON, Auteur . - p.1010-1020.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.1010-1020
Mots-clés : Children executive functioning flame retardants pregnancy resting state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS: In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. RESULTS: Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's = .05); (b) more reported EF problems (beta's = .001, FDR-corrected p's = .05). Higher global efficiency of brain areas involved in visual attention was associated with more EF problems (beta's = .01, FDR-corrected p's < .05). CONCLUSIONS: Intrinsic functional network organization of visual attention brain areas linked prenatal PBDE concentrations to EF problems in childhood. Visual attention may contribute to the development of higher-order cognitive functions, such as EF, which could be explored in future studies. En ligne : http://dx.doi.org/10.1111/jcpp.13040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder / Natalia M. KLEINHANS in Autism Research, 9-7 (July 2016)
[article]
Titre : Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Natalia M. KLEINHANS, Auteur ; Maya A. REITER, Auteur ; Emily NEUHAUS, Auteur ; Greg PAULEY, Auteur ; Nathalie MARTIN, Auteur ; Stephen R. DAGER, Auteur ; Annette ESTES, Auteur Article en page(s) : p.760-772 Langues : Anglais (eng) Mots-clés : autism amygdala resting state fMRI laterobasal superficial centromedial depression anxiety Index. décimale : PER Périodiques Résumé : The amygdala is a complex structure with distinct subregions and dissociable functional networks. The laterobasal subregion of the amygdala is hypothesized to mediate the presentation and severity of autism symptoms, although very little data are available regarding amygdala dysfunction at the subregional level. In this study, we investigated the relationship between abnormal amygdalar intrinsic connectivity, autism symptom severity, and anxiety and depressive symptoms. We collected resting state fMRI data on 31 high functioning adolescents and adults with autism spectrum disorder and 38 typically developing (TD) controls aged 14–45. Twenty-five participants with ASD and 28 TD participants were included in the final analyses. ASD participants were administered the Autism Diagnostic Interview–Revised and the Autism Diagnostic Observation Schedule. Adult participants were administered the Beck Depression Inventory II and the Beck Anxiety Inventory. Functional connectivity analyses were conducted from three amygdalar subregions: centromedial (CM), laterobasal (LB) and superficial (SF). In addition, correlations with the behavioral measures were tested in the adult participants. In general, the ASD group showed significantly decreased connectivity from the LB subregion and increased connectivity from the CM and SF subregions compared to the TD group. We found evidence that social symptoms are primarily associated with under-connectivity from the LB subregion whereas over-connectivity and under-connectivity from the CM, SF and LB subregions are related to co-morbid depression and anxiety in ASD, in brain regions that were distinct from those associated with social dysfunction, and in different patterns than were observed in mildly symptomatic TD participants. Our findings provide new evidence for functional subregional differences in amygdala pathophysiology in ASD. Autism Res 2016, 9: 760–772. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Autism Research > 9-7 (July 2016) . - p.760-772[article] Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder [Texte imprimé et/ou numérique] / Natalia M. KLEINHANS, Auteur ; Maya A. REITER, Auteur ; Emily NEUHAUS, Auteur ; Greg PAULEY, Auteur ; Nathalie MARTIN, Auteur ; Stephen R. DAGER, Auteur ; Annette ESTES, Auteur . - p.760-772.
Langues : Anglais (eng)
in Autism Research > 9-7 (July 2016) . - p.760-772
Mots-clés : autism amygdala resting state fMRI laterobasal superficial centromedial depression anxiety Index. décimale : PER Périodiques Résumé : The amygdala is a complex structure with distinct subregions and dissociable functional networks. The laterobasal subregion of the amygdala is hypothesized to mediate the presentation and severity of autism symptoms, although very little data are available regarding amygdala dysfunction at the subregional level. In this study, we investigated the relationship between abnormal amygdalar intrinsic connectivity, autism symptom severity, and anxiety and depressive symptoms. We collected resting state fMRI data on 31 high functioning adolescents and adults with autism spectrum disorder and 38 typically developing (TD) controls aged 14–45. Twenty-five participants with ASD and 28 TD participants were included in the final analyses. ASD participants were administered the Autism Diagnostic Interview–Revised and the Autism Diagnostic Observation Schedule. Adult participants were administered the Beck Depression Inventory II and the Beck Anxiety Inventory. Functional connectivity analyses were conducted from three amygdalar subregions: centromedial (CM), laterobasal (LB) and superficial (SF). In addition, correlations with the behavioral measures were tested in the adult participants. In general, the ASD group showed significantly decreased connectivity from the LB subregion and increased connectivity from the CM and SF subregions compared to the TD group. We found evidence that social symptoms are primarily associated with under-connectivity from the LB subregion whereas over-connectivity and under-connectivity from the CM, SF and LB subregions are related to co-morbid depression and anxiety in ASD, in brain regions that were distinct from those associated with social dysfunction, and in different patterns than were observed in mildly symptomatic TD participants. Our findings provide new evidence for functional subregional differences in amygdala pathophysiology in ASD. Autism Res 2016, 9: 760–772. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder in Autism Research, 11-12 (December 2018)
[article]
Titre : Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1643-1652 Langues : Anglais (eng) Mots-clés : autism spectrum disorder resting state fMRI support vector regression analysis young children Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical functional integration of brain regions. The vast majority of neuroimaging studies of ASD have focused on older children, adolescents, and adults with the disorder. Very little work has explored whole-brain functional connectivity of young children with ASD. Here, we collected resting-state functional magnetic resonance imaging data from 58 young children (mean age 4.98 years; 29 with ASD; 29 matched healthy controls [HC]). All children were under sedation during scanning. A functional "connectedness" method was first used to seek for brain regions showing atypical functional connectivity (FC) in children with ASD. Then, a recurrent-seek strategy was applied to reveal atypical FC circuits in ASD children. FC matrices between regions-of-interest (ROIs) were compared between ASD and HC. Finally, a support vector regression (SVR) method was used to assess the relationship between the FC circuits and ASD symptom severity. Two atypical FC circuits comprising 23 ROIs in ASD were revealed: one predominantly comprised brain regions involved with social cognition showing under-connectivity in ASD; the other predominantly comprised sensory-motor and visual brain regions showing over-connectivity in ASD. The SVR analysis showed that the two FC circuits were separately related to social deficits and restricted behavior scores. These findings indicate disrupted FC of neural circuits involved in the social and sensorimotor processes in young children with ASD. The finding of the atypical FC patterns in young children with ASD underscores the utility of studying younger children with the disorder, and highlights nuanced patterns of brain connectivity underlying behavior closer to disorder onset. Autism Research 2018, 11: 1643-1652. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder. Understanding brain functional alterations at early ages is important for understanding biological mechanisms of ASD. Here, we found two atypical brain functional circuits in young children with ASD that were related to social and sensorimotor function. These results show how atypical patterns of brain functional connectivity in young children with of ASD may underlie core symptoms of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372
in Autism Research > 11-12 (December 2018) . - p.1643-1652[article] Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder [Texte imprimé et/ou numérique] . - p.1643-1652.
Langues : Anglais (eng)
in Autism Research > 11-12 (December 2018) . - p.1643-1652
Mots-clés : autism spectrum disorder resting state fMRI support vector regression analysis young children Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical functional integration of brain regions. The vast majority of neuroimaging studies of ASD have focused on older children, adolescents, and adults with the disorder. Very little work has explored whole-brain functional connectivity of young children with ASD. Here, we collected resting-state functional magnetic resonance imaging data from 58 young children (mean age 4.98 years; 29 with ASD; 29 matched healthy controls [HC]). All children were under sedation during scanning. A functional "connectedness" method was first used to seek for brain regions showing atypical functional connectivity (FC) in children with ASD. Then, a recurrent-seek strategy was applied to reveal atypical FC circuits in ASD children. FC matrices between regions-of-interest (ROIs) were compared between ASD and HC. Finally, a support vector regression (SVR) method was used to assess the relationship between the FC circuits and ASD symptom severity. Two atypical FC circuits comprising 23 ROIs in ASD were revealed: one predominantly comprised brain regions involved with social cognition showing under-connectivity in ASD; the other predominantly comprised sensory-motor and visual brain regions showing over-connectivity in ASD. The SVR analysis showed that the two FC circuits were separately related to social deficits and restricted behavior scores. These findings indicate disrupted FC of neural circuits involved in the social and sensorimotor processes in young children with ASD. The finding of the atypical FC patterns in young children with ASD underscores the utility of studying younger children with the disorder, and highlights nuanced patterns of brain connectivity underlying behavior closer to disorder onset. Autism Research 2018, 11: 1643-1652. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder. Understanding brain functional alterations at early ages is important for understanding biological mechanisms of ASD. Here, we found two atypical brain functional circuits in young children with ASD that were related to social and sensorimotor function. These results show how atypical patterns of brain functional connectivity in young children with of ASD may underlie core symptoms of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372 Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder / Ville RAATIKAINEN in Autism Research, 13-2 (February 2020)
[article]
Titre : Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ville RAATIKAINEN, Auteur ; Vesa KORHONEN, Auteur ; Viola BORCHARDT, Auteur ; Niko HUOTARI, Auteur ; Heta HELAKARI, Auteur ; Janne KANANEN, Auteur ; Lauri RAITAMAA, Auteur ; Leena JOSKITT, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Lucina Q. UDDIN, Auteur ; Vesa KIVINIEMI, Auteur ; Finnish Epilepsy ASSOCIATION, Auteur ; Instrumentariumin TIEDESAATIO, Auteur ; Jane ja Aatos Erkon SAATIO, Auteur Article en page(s) : p.244-258 Langues : Anglais (eng) Mots-clés : Asd Mreg dynamic lag analysis human brain lag pattern resting state fMRI Index. décimale : PER Périodiques Résumé : This study investigated whole-brain dynamic lag pattern variations between neurotypical (NT) individuals and individuals with autism spectrum disorder (ASD) by applying a novel technique called dynamic lag analysis (DLA). The use of 3D magnetic resonance encephalography data with repetition time = 100 msec enables highly accurate analysis of the spread of activity between brain networks. Sixteen resting-state networks (RSNs) with the highest spatial correlation between NT individuals (n = 20) and individuals with ASD (n = 20) were analyzed. The dynamic lag pattern variation between each RSN pair was investigated using DLA, which measures time lag variation between each RSN pair combination and statistically defines how these lag patterns are altered between ASD and NT groups. DLA analyses indicated that 10.8% of the 120 RSN pairs had statistically significant (P-value <0.003) dynamic lag pattern differences that survived correction with surrogate data thresholding. Alterations in lag patterns were concentrated in salience, executive, visual, and default-mode networks, supporting earlier findings of impaired brain connectivity in these regions in ASD. 92.3% and 84.6% of the significant RSN pairs revealed shorter mean and median temporal lags in ASD versus NT, respectively. Taken together, these results suggest that altered lag patterns indicating atypical spread of activity between large-scale functional brain networks may contribute to the ASD phenotype. Autism Res 2020, 13: 244-258. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is characterized by atypical neurodevelopment. Using an ultra-fast neuroimaging procedure, we investigated communication across brain regions in adults with ASD compared with neurotypical (NT) individuals. We found that ASD individuals had altered information flow patterns across brain regions. Atypical patterns were concentrated in salience, executive, visual, and default-mode network areas of the brain that have previously been implicated in the pathophysiology of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420
in Autism Research > 13-2 (February 2020) . - p.244-258[article] Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder [Texte imprimé et/ou numérique] / Ville RAATIKAINEN, Auteur ; Vesa KORHONEN, Auteur ; Viola BORCHARDT, Auteur ; Niko HUOTARI, Auteur ; Heta HELAKARI, Auteur ; Janne KANANEN, Auteur ; Lauri RAITAMAA, Auteur ; Leena JOSKITT, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Lucina Q. UDDIN, Auteur ; Vesa KIVINIEMI, Auteur ; Finnish Epilepsy ASSOCIATION, Auteur ; Instrumentariumin TIEDESAATIO, Auteur ; Jane ja Aatos Erkon SAATIO, Auteur . - p.244-258.
Langues : Anglais (eng)
in Autism Research > 13-2 (February 2020) . - p.244-258
Mots-clés : Asd Mreg dynamic lag analysis human brain lag pattern resting state fMRI Index. décimale : PER Périodiques Résumé : This study investigated whole-brain dynamic lag pattern variations between neurotypical (NT) individuals and individuals with autism spectrum disorder (ASD) by applying a novel technique called dynamic lag analysis (DLA). The use of 3D magnetic resonance encephalography data with repetition time = 100 msec enables highly accurate analysis of the spread of activity between brain networks. Sixteen resting-state networks (RSNs) with the highest spatial correlation between NT individuals (n = 20) and individuals with ASD (n = 20) were analyzed. The dynamic lag pattern variation between each RSN pair was investigated using DLA, which measures time lag variation between each RSN pair combination and statistically defines how these lag patterns are altered between ASD and NT groups. DLA analyses indicated that 10.8% of the 120 RSN pairs had statistically significant (P-value <0.003) dynamic lag pattern differences that survived correction with surrogate data thresholding. Alterations in lag patterns were concentrated in salience, executive, visual, and default-mode networks, supporting earlier findings of impaired brain connectivity in these regions in ASD. 92.3% and 84.6% of the significant RSN pairs revealed shorter mean and median temporal lags in ASD versus NT, respectively. Taken together, these results suggest that altered lag patterns indicating atypical spread of activity between large-scale functional brain networks may contribute to the ASD phenotype. Autism Res 2020, 13: 244-258. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is characterized by atypical neurodevelopment. Using an ultra-fast neuroimaging procedure, we investigated communication across brain regions in adults with ASD compared with neurotypical (NT) individuals. We found that ASD individuals had altered information flow patterns across brain regions. Atypical patterns were concentrated in salience, executive, visual, and default-mode network areas of the brain that have previously been implicated in the pathophysiology of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420