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Prediction of early-onset bipolar using electronic health records / Bo WANG in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1141-1154 Titre : Prediction of early-onset bipolar using electronic health records Type de document : texte imprimé Auteurs : Bo WANG, Auteur ; Yi-Han SHEU, Auteur ; Hyunjoon LEE, Auteur ; Robert G. MEALER, Auteur ; Victor M. CASTRO, Auteur ; Jordan W. SMOLLER, Auteur Article en page(s) : p.1141-1154 Langues : Anglais (eng) Mots-clés : Early-onset bipolar disorder  mood disorders  risk prediction  electronic health record  machine learning Index. décimale : PER Périodiques Résumé : Background Early identification of bipolar disorder (BD) provides an important opportunity for timely intervention. In this study, we aimed to develop machine learning models using large-scale electronic health record (EHR) data including clinical notes for predicting early-onset BD. Methods Structured and unstructured data were extracted from the longitudinal EHR of the Mass General Brigham health system. We defined three cohorts aged 10 25 years: (1) the full youth cohort (N 300,398); (2) a subcohort defined by having a mental health visit (N 105,461); and (3) a subcohort defined by having a diagnosis of mood disorder or ADHD (N 35,213). By adopting a prospective landmark modeling approach that aligns with clinical practice, we developed and validated a range of machine learning models, across different cohorts and prediction windows. Results We found the two tree-based models, random forests (RF) and light gradient-boosting machine (LGBM), achieving good discriminative performance across different clinical settings (area under the receiver operating characteristic curve 0.76 0.88 for RF and 0.74 0.89 for LGBM). In addition, we showed comparable performance can be achieved with a greatly reduced set of features, demonstrating computational efficiency can be attained without significant compromise of model accuracy. Conclusions Good discriminative performance for models predicting early-onset BD can be achieved utilizing large-scale EHR data. Our study offers a scalable and accurate method for identifying youth at risk for BD that could help inform clinical decision-making and facilitate early intervention. Future work includes evaluating the portability of our approach to other healthcare systems and exploring considerations regarding possible implementation. En ligne : https://doi.org/10.1111/jcpp.14131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Prediction of early-onset bipolar using electronic health records [texte imprimé] / Bo WANG, Auteur ; Yi-Han SHEU, Auteur ; Hyunjoon LEE, Auteur ; Robert G. MEALER, Auteur ; Victor M. CASTRO, Auteur ; Jordan W. SMOLLER, Auteur . - p.1141-1154. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1141-1154 Mots-clés : Early-onset bipolar disorder  mood disorders  risk prediction  electronic health record  machine learning Index. décimale : PER Périodiques Résumé : Background Early identification of bipolar disorder (BD) provides an important opportunity for timely intervention. In this study, we aimed to develop machine learning models using large-scale electronic health record (EHR) data including clinical notes for predicting early-onset BD. Methods Structured and unstructured data were extracted from the longitudinal EHR of the Mass General Brigham health system. We defined three cohorts aged 10 25 years: (1) the full youth cohort (N 300,398); (2) a subcohort defined by having a mental health visit (N 105,461); and (3) a subcohort defined by having a diagnosis of mood disorder or ADHD (N 35,213). By adopting a prospective landmark modeling approach that aligns with clinical practice, we developed and validated a range of machine learning models, across different cohorts and prediction windows. Results We found the two tree-based models, random forests (RF) and light gradient-boosting machine (LGBM), achieving good discriminative performance across different clinical settings (area under the receiver operating characteristic curve 0.76 0.88 for RF and 0.74 0.89 for LGBM). In addition, we showed comparable performance can be achieved with a greatly reduced set of features, demonstrating computational efficiency can be attained without significant compromise of model accuracy. Conclusions Good discriminative performance for models predicting early-onset BD can be achieved utilizing large-scale EHR data. Our study offers a scalable and accurate method for identifying youth at risk for BD that could help inform clinical decision-making and facilitate early intervention. Future work includes evaluating the portability of our approach to other healthcare systems and exploring considerations regarding possible implementation. En ligne : https://doi.org/10.1111/jcpp.14131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565