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Shared atypical default mode and salience network functional connectivity between autism and schizophrenia / Heng CHEN in Autism Research, 10-11 (November 2017)
[article]
Titre : Shared atypical default mode and salience network functional connectivity between autism and schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Heng CHEN, Auteur ; Lucina Q. UDDIN, Auteur ; Xujun DUAN, Auteur ; Junjie ZHENG, Auteur ; Zhiliang LONG, Auteur ; Youxue ZHANG, Auteur ; Xiaonan GUO, Auteur ; Yan ZHANG, Auteur ; Jingping ZHAO, Auteur ; Huafu CHEN, Auteur Article en page(s) : p.1776-1786 Langues : Anglais (eng) Mots-clés : schizophrenia autism spectrum disorder functional connectivity multivariate pattern analysis default mode network salience network Index. décimale : PER Périodiques Résumé : Schizophrenia and autism spectrum disorder (ASD) are two prevalent neurodevelopmental disorders sharing some similar genetic basis and clinical features. The extent to which they share common neural substrates remains unclear. Resting-state fMRI data were collected from 35 drug-naïve adolescent participants with first-episode schizophrenia (15.6?±?1.8 years old) and 31 healthy controls (15.4?±?1.6 years old). Data from 22 participants with ASD (13.1?±?3.1 years old) and 21 healthy controls (12.9?±?2.9 years old) were downloaded from the Autism Brain Imaging Data Exchange. Resting-state functional networks were constructed using predefined regions of interest. Multivariate pattern analysis combined with multi-task regression feature selection methods were conducted in two datasets separately. Classification between individuals with disorders and controls was achieved with high accuracy (schizophrenia dataset: accuracy?=?83%; ASD dataset: accuracy?=?80%). Shared atypical brain connections contributing to classification were mostly present in the default mode network (DMN) and salience network (SN). These functional connections were further related to severity of social deficits in ASD (p?=?0.002). Distinct atypical connections were also more related to the DMN and SN, but showed different atypical connectivity patterns between the two disorders. These results suggest some common neural mechanisms contributing to schizophrenia and ASD, and may aid in understanding the pathology of these two neurodevelopmental disorders. Autism Res 2017, 10: 1776–1786. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay summary Autism spectrum disorder (ASD) and schizophrenia are two common neurodevelopmental disorders which share several genetic and behavioral features. The present study identified common neural mechanisms contributing to ASD and schizophrenia using resting-state functional MRI data. The results may help to understand the pathology of these two neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1776-1786[article] Shared atypical default mode and salience network functional connectivity between autism and schizophrenia [Texte imprimé et/ou numérique] / Heng CHEN, Auteur ; Lucina Q. UDDIN, Auteur ; Xujun DUAN, Auteur ; Junjie ZHENG, Auteur ; Zhiliang LONG, Auteur ; Youxue ZHANG, Auteur ; Xiaonan GUO, Auteur ; Yan ZHANG, Auteur ; Jingping ZHAO, Auteur ; Huafu CHEN, Auteur . - p.1776-1786.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1776-1786
Mots-clés : schizophrenia autism spectrum disorder functional connectivity multivariate pattern analysis default mode network salience network Index. décimale : PER Périodiques Résumé : Schizophrenia and autism spectrum disorder (ASD) are two prevalent neurodevelopmental disorders sharing some similar genetic basis and clinical features. The extent to which they share common neural substrates remains unclear. Resting-state fMRI data were collected from 35 drug-naïve adolescent participants with first-episode schizophrenia (15.6?±?1.8 years old) and 31 healthy controls (15.4?±?1.6 years old). Data from 22 participants with ASD (13.1?±?3.1 years old) and 21 healthy controls (12.9?±?2.9 years old) were downloaded from the Autism Brain Imaging Data Exchange. Resting-state functional networks were constructed using predefined regions of interest. Multivariate pattern analysis combined with multi-task regression feature selection methods were conducted in two datasets separately. Classification between individuals with disorders and controls was achieved with high accuracy (schizophrenia dataset: accuracy?=?83%; ASD dataset: accuracy?=?80%). Shared atypical brain connections contributing to classification were mostly present in the default mode network (DMN) and salience network (SN). These functional connections were further related to severity of social deficits in ASD (p?=?0.002). Distinct atypical connections were also more related to the DMN and SN, but showed different atypical connectivity patterns between the two disorders. These results suggest some common neural mechanisms contributing to schizophrenia and ASD, and may aid in understanding the pathology of these two neurodevelopmental disorders. Autism Res 2017, 10: 1776–1786. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay summary Autism spectrum disorder (ASD) and schizophrenia are two common neurodevelopmental disorders which share several genetic and behavioral features. The present study identified common neural mechanisms contributing to ASD and schizophrenia using resting-state functional MRI data. The results may help to understand the pathology of these two neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents / Moriah E. THOMASON in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)
[article]
Titre : Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Moriah E. THOMASON, Auteur ; J. Paul HAMILTON, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2011 Article en page(s) : p.1026-1034 Langues : Anglais (eng) Mots-clés : Resting-state adolescents HPA axis stress subgenual cingulate fMRI salience network connectivity Index. décimale : PER Périodiques Résumé : Background: Responses to stress vary greatly in young adolescents, and little is known about neural correlates of the stress response in youth. The purpose of this study was to examine whether variability in cortisol responsivity following a social stress test in young adolescents is associated with altered neural functional connectivity (FC) of the salience network (SN) measured during resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: Forty-nine typically developing young adolescents participated in a social stress test during which they contributed salivary cortisol samples. Following this, they underwent rs-fMRI scanning. We examined the association of FC of the SN [composed of anterior cingulate cortex and bilateral anterior insula regions] with cortisol responsivity.
Results: Greater cortisol responsivity was significantly positively correlated with higher FC between subgenual anterior cingulate cortex (Cg25) and the SN, controlling for participant age. There were no regions of the brain that showed an inverse relation.
Conclusions: Brain systems that have been implicated in autonomic arousal and that influence subjective feeling states show altered FC associated with stress responsivity in early life.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02422.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142
in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1026-1034[article] Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents [Texte imprimé et/ou numérique] / Moriah E. THOMASON, Auteur ; J. Paul HAMILTON, Auteur ; Ian H. GOTLIB, Auteur . - 2011 . - p.1026-1034.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1026-1034
Mots-clés : Resting-state adolescents HPA axis stress subgenual cingulate fMRI salience network connectivity Index. décimale : PER Périodiques Résumé : Background: Responses to stress vary greatly in young adolescents, and little is known about neural correlates of the stress response in youth. The purpose of this study was to examine whether variability in cortisol responsivity following a social stress test in young adolescents is associated with altered neural functional connectivity (FC) of the salience network (SN) measured during resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: Forty-nine typically developing young adolescents participated in a social stress test during which they contributed salivary cortisol samples. Following this, they underwent rs-fMRI scanning. We examined the association of FC of the SN [composed of anterior cingulate cortex and bilateral anterior insula regions] with cortisol responsivity.
Results: Greater cortisol responsivity was significantly positively correlated with higher FC between subgenual anterior cingulate cortex (Cg25) and the SN, controlling for participant age. There were no regions of the brain that showed an inverse relation.
Conclusions: Brain systems that have been implicated in autonomic arousal and that influence subjective feeling states show altered FC associated with stress responsivity in early life.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02422.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology / R. LAJINESS-O'NEILL in Autism Research, 11-3 (March 2018)
[article]
Titre : Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology Type de document : Texte imprimé et/ou numérique Auteurs : R. LAJINESS-O'NEILL, Auteur ; J. R. BRENNAN, Auteur ; J. E. MORAN, Auteur ; A. E. RICHARD, Auteur ; A. M. FLORES, Auteur ; C. SWICK, Auteur ; R. GOODCASE, Auteur ; T. ANDERSEN, Auteur ; K. MCFARLANE, Auteur ; K. RUSINIAK, Auteur ; I. KOVELMAN, Auteur ; N. WAGLEY, Auteur ; M. UGOLINI, Auteur ; Jordan ALBRIGHT, Auteur ; S. M. BOWYER, Auteur Article en page(s) : p.434-449 Langues : Anglais (eng) Mots-clés : autism spectrum disorder coherence default mode network gamma magnetoencephalography salience network synchrony Index. décimale : PER Périodiques Résumé : Disrupted neural synchrony may be a primary electrophysiological abnormality in autism spectrum disorders (ASD), altering communication between discrete brain regions and contributing to abnormalities in patterns of connectivity within identified neural networks. Studies exploring brain dynamics to comprehensively characterize and link connectivity to large-scale cortical networks and clinical symptoms are lagging considerably. Patterns of neural coherence within the Default Mode Network (DMN) and Salience Network (SN) during resting state were investigated in 12 children with ASD (MAge = 9.2) and 13 age and gender-matched neurotypicals (NT) (MAge = 9.3) with magnetoencephalography. Coherence between 231 brain region pairs within four frequency bands (theta (4-7 Hz), alpha, (8-12 Hz), beta (13-30 Hz), and gamma (30-80 Hz)) was calculated. Relationships between neural coherence and social functioning were examined. ASD was characterized by lower synchronization across all frequencies, reaching clinical significance in the gamma band. Lower gamma synchrony between fronto-temporo-parietal regions was observed, partially consistent with diminished default mode network (DMN) connectivity. Lower gamma coherence in ASD was evident in cross-hemispheric connections between: angular with inferior/middle frontal; middle temporal with middle/inferior frontal; and within right-hemispheric connections between angular, middle temporal, and inferior/middle frontal cortices. Lower gamma coherence between left angular and left superior frontal, right inferior/middle frontal, and right precuneus and between right angular and inferior/middle frontal cortices was related to lower social/social-communication functioning. Results suggest a pattern of lower gamma band coherence in a subset of regions within the DMN in ASD (angular and middle temporal cortical areas) related to lower social/social-communicative functioning. Autism Res 2018, 11: 434-449. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Communication between different areas of the brain was observed in children with ASD and neurotypical children while awake, but not working on a task. Magnetoencephalography was used to measure tiny magnetic fields naturally generated via brain activity. The brains of children with ASD showed less communication between areas that are important for social information processing compared to the brains of neurotypical children. The amount of communication between these areas was associated with social and social communication difficulties. En ligne : http://dx.doi.org/10.1002/aur.1908 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352
in Autism Research > 11-3 (March 2018) . - p.434-449[article] Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology [Texte imprimé et/ou numérique] / R. LAJINESS-O'NEILL, Auteur ; J. R. BRENNAN, Auteur ; J. E. MORAN, Auteur ; A. E. RICHARD, Auteur ; A. M. FLORES, Auteur ; C. SWICK, Auteur ; R. GOODCASE, Auteur ; T. ANDERSEN, Auteur ; K. MCFARLANE, Auteur ; K. RUSINIAK, Auteur ; I. KOVELMAN, Auteur ; N. WAGLEY, Auteur ; M. UGOLINI, Auteur ; Jordan ALBRIGHT, Auteur ; S. M. BOWYER, Auteur . - p.434-449.
Langues : Anglais (eng)
in Autism Research > 11-3 (March 2018) . - p.434-449
Mots-clés : autism spectrum disorder coherence default mode network gamma magnetoencephalography salience network synchrony Index. décimale : PER Périodiques Résumé : Disrupted neural synchrony may be a primary electrophysiological abnormality in autism spectrum disorders (ASD), altering communication between discrete brain regions and contributing to abnormalities in patterns of connectivity within identified neural networks. Studies exploring brain dynamics to comprehensively characterize and link connectivity to large-scale cortical networks and clinical symptoms are lagging considerably. Patterns of neural coherence within the Default Mode Network (DMN) and Salience Network (SN) during resting state were investigated in 12 children with ASD (MAge = 9.2) and 13 age and gender-matched neurotypicals (NT) (MAge = 9.3) with magnetoencephalography. Coherence between 231 brain region pairs within four frequency bands (theta (4-7 Hz), alpha, (8-12 Hz), beta (13-30 Hz), and gamma (30-80 Hz)) was calculated. Relationships between neural coherence and social functioning were examined. ASD was characterized by lower synchronization across all frequencies, reaching clinical significance in the gamma band. Lower gamma synchrony between fronto-temporo-parietal regions was observed, partially consistent with diminished default mode network (DMN) connectivity. Lower gamma coherence in ASD was evident in cross-hemispheric connections between: angular with inferior/middle frontal; middle temporal with middle/inferior frontal; and within right-hemispheric connections between angular, middle temporal, and inferior/middle frontal cortices. Lower gamma coherence between left angular and left superior frontal, right inferior/middle frontal, and right precuneus and between right angular and inferior/middle frontal cortices was related to lower social/social-communication functioning. Results suggest a pattern of lower gamma band coherence in a subset of regions within the DMN in ASD (angular and middle temporal cortical areas) related to lower social/social-communicative functioning. Autism Res 2018, 11: 434-449. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Communication between different areas of the brain was observed in children with ASD and neurotypical children while awake, but not working on a task. Magnetoencephalography was used to measure tiny magnetic fields naturally generated via brain activity. The brains of children with ASD showed less communication between areas that are important for social information processing compared to the brains of neurotypical children. The amount of communication between these areas was associated with social and social communication difficulties. En ligne : http://dx.doi.org/10.1002/aur.1908 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352