2 recherche sur le mot-clé 'sleep disorder'

The role of circadian rhythms and sleep in the aetiology of autism spectrum disorder and attention-deficit/hyperactivity disorder: New evidence from bidirectional two-sample Mendelian randomization analysis / Xiaotian DAI in Autism, 29-1 (January 2025)  

Public ISBD [article]  inAutism > 29-1 (January 2025) . - p.76-86 Titre : The role of circadian rhythms and sleep in the aetiology of autism spectrum disorder and attention-deficit/hyperactivity disorder: New evidence from bidirectional two-sample Mendelian randomization analysis Type de document : texte imprimé Auteurs : Xiaotian DAI, Auteur ; Gareth J. WILLIAMS, Auteur ; John A. GROEGER, Auteur ; Gary JONES, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wei ZHOU, Auteur ; Jing HUA, Auteur ; Wenchong DU, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  autism spectrum disorder  chronotype  circadian rhythm  Mendelian randomization  sleep disorder Index. décimale : PER Périodiques Résumé : Increasing evidence highlights the role of disrupted circadian rhythms in the neural dysfunctions and sleep disturbances observed in autism spectrum disorder and attention-deficit/hyperactivity disorder. However, the causality and directionality of these associations remain unclear. In this study, we employed a bidirectional two-sample Mendelian randomization framework, leveraging genome-wide association study data from the UK Biobank (n = 85,670) and FinnGen (n = 377,277). Genetic variants served as instrumental variables to infer causation, and objective accelerometer-derived metrics identified circadian rhythm and sleep genetic instruments. The results showed that the timing of the most active 10 h was significantly linked to higher odds of autism spectrum disorder and attention-deficit/hyperactivity disorder. Independently, higher sleep efficiency predicted a lower risk of autism spectrum disorder, while attention-deficit/hyperactivity disorder was linked to an increase in nocturnal sleep episodes. Heterogeneity and sensitivity analyses confirmed these findings. Our study establishes causal links between circadian alterations and autism spectrum disorder and attention-deficit/hyperactivity disorder, distinguishing the independent and protective role of sleep efficiency in autism spectrum disorder from circadian rhythms. In attention-deficit/hyperactivity disorder, however, disrupted sleep appears as a consequence, not a cause. These insights highlight divergent interactions with sleep factors in autism spectrum disorder and attention-deficit/hyperactivity disorder, laying the groundwork for tailored therapeutic strategies that recognize the distinct influences of sleep quality and circadian rhythms in each disorder.Lay abstractResearch shows that people with autism spectrum disorder and attention-deficit/hyperactivity disorder often have sleep issues and problems with the body?s natural daily rhythms, known as circadian rhythms. By exploring the genetic variants associated with these rhythms and the conditions, this study reveals that these rhythm changes and sleep patterns are directly linked to autism spectrum disorder and attention-deficit/hyperactivity disorder. It found that the timing of one?s most active hours can increase the likelihood of having both autism spectrum disorder and attention-deficit/hyperactivity disorder. Importantly, it also shows that good sleep quality might protect against autism spectrum disorder, while disturbed sleep in people with attention-deficit/hyperactivity disorder seems to be a result rather than the cause of the condition. This understanding can help doctors and researchers develop better treatment approaches that focus on the specific ways sleep and body rhythms affect those with autism spectrum disorder and attention-deficit/hyperactivity disorder, considering their unique associations with circadian rhythms and sleep patterns. Understanding these unique links can lead to more effective, personalized care for those affected by these conditions. En ligne : https://dx.doi.org/10.1177/13623613241258546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] The role of circadian rhythms and sleep in the aetiology of autism spectrum disorder and attention-deficit/hyperactivity disorder: New evidence from bidirectional two-sample Mendelian randomization analysis [texte imprimé] / Xiaotian DAI, Auteur ; Gareth J. WILLIAMS, Auteur ; John A. GROEGER, Auteur ; Gary JONES, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wei ZHOU, Auteur ; Jing HUA, Auteur ; Wenchong DU, Auteur . - p.76-86. Langues : Anglais (eng) in Autism > 29-1 (January 2025) . - p.76-86 Mots-clés : attention-deficit/hyperactivity disorder  autism spectrum disorder  chronotype  circadian rhythm  Mendelian randomization  sleep disorder Index. décimale : PER Périodiques Résumé : Increasing evidence highlights the role of disrupted circadian rhythms in the neural dysfunctions and sleep disturbances observed in autism spectrum disorder and attention-deficit/hyperactivity disorder. However, the causality and directionality of these associations remain unclear. In this study, we employed a bidirectional two-sample Mendelian randomization framework, leveraging genome-wide association study data from the UK Biobank (n = 85,670) and FinnGen (n = 377,277). Genetic variants served as instrumental variables to infer causation, and objective accelerometer-derived metrics identified circadian rhythm and sleep genetic instruments. The results showed that the timing of the most active 10 h was significantly linked to higher odds of autism spectrum disorder and attention-deficit/hyperactivity disorder. Independently, higher sleep efficiency predicted a lower risk of autism spectrum disorder, while attention-deficit/hyperactivity disorder was linked to an increase in nocturnal sleep episodes. Heterogeneity and sensitivity analyses confirmed these findings. Our study establishes causal links between circadian alterations and autism spectrum disorder and attention-deficit/hyperactivity disorder, distinguishing the independent and protective role of sleep efficiency in autism spectrum disorder from circadian rhythms. In attention-deficit/hyperactivity disorder, however, disrupted sleep appears as a consequence, not a cause. These insights highlight divergent interactions with sleep factors in autism spectrum disorder and attention-deficit/hyperactivity disorder, laying the groundwork for tailored therapeutic strategies that recognize the distinct influences of sleep quality and circadian rhythms in each disorder.Lay abstractResearch shows that people with autism spectrum disorder and attention-deficit/hyperactivity disorder often have sleep issues and problems with the body?s natural daily rhythms, known as circadian rhythms. By exploring the genetic variants associated with these rhythms and the conditions, this study reveals that these rhythm changes and sleep patterns are directly linked to autism spectrum disorder and attention-deficit/hyperactivity disorder. It found that the timing of one?s most active hours can increase the likelihood of having both autism spectrum disorder and attention-deficit/hyperactivity disorder. Importantly, it also shows that good sleep quality might protect against autism spectrum disorder, while disturbed sleep in people with attention-deficit/hyperactivity disorder seems to be a result rather than the cause of the condition. This understanding can help doctors and researchers develop better treatment approaches that focus on the specific ways sleep and body rhythms affect those with autism spectrum disorder and attention-deficit/hyperactivity disorder, considering their unique associations with circadian rhythms and sleep patterns. Understanding these unique links can lead to more effective, personalized care for those affected by these conditions. En ligne : https://dx.doi.org/10.1177/13623613241258546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder / Ghizlane GAOUGAOU in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder Type de document : texte imprimé Auteurs : Ghizlane GAOUGAOU, Auteur ; Riham ZAHRA, Auteur ; Sophia MOREL, Auteur ; Véronique BÉLANGER, Auteur ; Inga Sophia KNOTH, Auteur ; Dominique COUSINEAU, Auteur ; Baudouin Forgeot D'ARC, Auteur ; Kelly GRZYWACZ, Auteur ; Guy ROUSSEAU, Auteur ; Eric DÉZIEL, Auteur ; Roger GODBOUT, Auteur ; Sarah LIPPE, Auteur ; Mathieu MILLETTE, Auteur ; Valérie MARCIL, Auteur Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder/diet therapy/complications  Probiotics/administration & dosage/adverse effects/therapeutic use  Male  Child  Female  Child, Preschool  Feasibility Studies  Gastrointestinal Diseases  Sleep Wake Disorders  Dietary Supplements  Beverages  Patient Acceptance of Health Care  Acceptability  Autism spectrum disorders  Autistic symptoms  Children  Feasibility  Gastrointestinal symptoms  Probiotics  Safety  Sleep disorder  by the ethics review board of the CHU Sainte-Justine (#2021–3412). Informed  consent was obtained from all participants and parents involved in the study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication and social interaction. ASD is associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms and sleep disorders. Evidence supports an association between intestinal dysbiosis and the severity of ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis and decrease neurobehavioral, GI and sleep symptoms in individuals diagnosed with autism. METHODS: This study aims to evaluate the acceptability and safety of a Bio-K + probiotics beverage in autistic children aged 4 to 11 years and the feasibility of the proposed research protocol to measure its impact on behaviors and comorbidities. The 30-week study consisted of daily supplementation with Bio-K + probiotics for 14 weeks. Acceptability and safety were monitored throughout the study. Feasibility was assessed by comparing recruitment and completion rates to pre-established thresholds. Preliminary impact of supplementation on behaviors (Autism Treatment Evaluation Checklist (ATEC) score), GI symptoms and sleep disorders was evaluated. RESULTS: Of the 23 children recruited (mean age 6.7 ± 2.2 years, 70% males), 65% had GI problems and 91% had sleep disorders. Probiotic supplementation was accepted by all participants and no product-related adverse event was reported. Feasibility rates exceeded pre-established thresholds for almost all study outcomes including recruitment rate, compliance, electroencephalography, actigraphy and completion of questionnaires. Preliminary data suggest an improvement in behaviors associated with autism assessed with the total ATEC score, and in GI symptoms and sleep disorders. CONCLUSION: This study demonstrates probiotic beverage acceptability and safety and protocol feasibility in autistic children. To further support our data, a double-blinded placebo-controlled study is needed to determine its efficacy. En ligne : https://dx.doi.org/10.1186/s11689-025-09617-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder [texte imprimé] / Ghizlane GAOUGAOU, Auteur ; Riham ZAHRA, Auteur ; Sophia MOREL, Auteur ; Véronique BÉLANGER, Auteur ; Inga Sophia KNOTH, Auteur ; Dominique COUSINEAU, Auteur ; Baudouin Forgeot D'ARC, Auteur ; Kelly GRZYWACZ, Auteur ; Guy ROUSSEAU, Auteur ; Eric DÉZIEL, Auteur ; Roger GODBOUT, Auteur ; Sarah LIPPE, Auteur ; Mathieu MILLETTE, Auteur ; Valérie MARCIL, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Autism Spectrum Disorder/diet therapy/complications  Probiotics/administration & dosage/adverse effects/therapeutic use  Male  Child  Female  Child, Preschool  Feasibility Studies  Gastrointestinal Diseases  Sleep Wake Disorders  Dietary Supplements  Beverages  Patient Acceptance of Health Care  Acceptability  Autism spectrum disorders  Autistic symptoms  Children  Feasibility  Gastrointestinal symptoms  Probiotics  Safety  Sleep disorder  by the ethics review board of the CHU Sainte-Justine (#2021–3412). Informed  consent was obtained from all participants and parents involved in the study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication and social interaction. ASD is associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms and sleep disorders. Evidence supports an association between intestinal dysbiosis and the severity of ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis and decrease neurobehavioral, GI and sleep symptoms in individuals diagnosed with autism. METHODS: This study aims to evaluate the acceptability and safety of a Bio-K + probiotics beverage in autistic children aged 4 to 11 years and the feasibility of the proposed research protocol to measure its impact on behaviors and comorbidities. The 30-week study consisted of daily supplementation with Bio-K + probiotics for 14 weeks. Acceptability and safety were monitored throughout the study. Feasibility was assessed by comparing recruitment and completion rates to pre-established thresholds. Preliminary impact of supplementation on behaviors (Autism Treatment Evaluation Checklist (ATEC) score), GI symptoms and sleep disorders was evaluated. RESULTS: Of the 23 children recruited (mean age 6.7 ± 2.2 years, 70% males), 65% had GI problems and 91% had sleep disorders. Probiotic supplementation was accepted by all participants and no product-related adverse event was reported. Feasibility rates exceeded pre-established thresholds for almost all study outcomes including recruitment rate, compliance, electroencephalography, actigraphy and completion of questionnaires. Preliminary data suggest an improvement in behaviors associated with autism assessed with the total ATEC score, and in GI symptoms and sleep disorders. CONCLUSION: This study demonstrates probiotic beverage acceptability and safety and protocol feasibility in autistic children. To further support our data, a double-blinded placebo-controlled study is needed to determine its efficacy. En ligne : https://dx.doi.org/10.1186/s11689-025-09617-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576