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2 recherche sur le mot-clé 'stress sensitization'
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Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores / Lisa R. STARR in Development and Psychopathology, 33-4 (October 2021)
[article]
Titre : Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores Type de document : Texte imprimé et/ou numérique Auteurs : Lisa R. STARR, Auteur ; Catherine B. STROUD, Auteur ; Zoey A. SHAW, Auteur ; Suzanne VRSHEK-SCHALLHORN, Auteur Article en page(s) : p.1264-1278 Langues : Anglais (eng) Mots-clés : childhood adversity depression gene-by-environment interaction genetic stress sensitization stressful life events Index. décimale : PER Périodiques Résumé : Childhood adversity appears to sensitize youth to stress, increasing depression risk following stressful life events occurring throughout the lifespan. Some evidence suggests hypothalamic–pituitary–adrenal (HPA) axis-related and serotonergic genetic variation moderates this effect, in a “gene-by-environment-by-environment” interaction (G × E × E). However, prior research has tested single genetic variants, limiting power. The current study uses a multilocus genetic profile score (MGPS) approach to capture polygenic risk relevant to HPA axis and serotonergic functioning. Adolescents (N = 241, Mage = 15.90) completed contextual-threat-based interviews assessing childhood adversity and acute life events, and diagnostic interviews assessing depression. Established MGPSs indexed genetic variation linked to HPA axis (10 single nucleotide polymorphisms [SNPs]) and serotonergic (five SNPs) functioning. Results showed significant MGPS × Childhood Adversity × Recent Life Stress interactions predicting depression for both HPA axis and serotonergic MGPSs, with both risk scores predicting stronger Childhood Adversity × Recent Stress interactions. Serotonergic genetic risk specifically predicted sensitization to major interpersonal stressors. The serotonergic MGPS G × E × E was re-tested in an independent replication sample of early adolescent girls, with comparable results. Findings support the notion that genetic variation linked to these two neurobiological symptoms alters stress sensitization, and that gene-by-environment (G × E) interactions may be qualified by environmental exposures occurring at different points in development. En ligne : http://dx.doi.org/10.1017/S0954579420000474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Development and Psychopathology > 33-4 (October 2021) . - p.1264-1278[article] Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores [Texte imprimé et/ou numérique] / Lisa R. STARR, Auteur ; Catherine B. STROUD, Auteur ; Zoey A. SHAW, Auteur ; Suzanne VRSHEK-SCHALLHORN, Auteur . - p.1264-1278.
Langues : Anglais (eng)
in Development and Psychopathology > 33-4 (October 2021) . - p.1264-1278
Mots-clés : childhood adversity depression gene-by-environment interaction genetic stress sensitization stressful life events Index. décimale : PER Périodiques Résumé : Childhood adversity appears to sensitize youth to stress, increasing depression risk following stressful life events occurring throughout the lifespan. Some evidence suggests hypothalamic–pituitary–adrenal (HPA) axis-related and serotonergic genetic variation moderates this effect, in a “gene-by-environment-by-environment” interaction (G × E × E). However, prior research has tested single genetic variants, limiting power. The current study uses a multilocus genetic profile score (MGPS) approach to capture polygenic risk relevant to HPA axis and serotonergic functioning. Adolescents (N = 241, Mage = 15.90) completed contextual-threat-based interviews assessing childhood adversity and acute life events, and diagnostic interviews assessing depression. Established MGPSs indexed genetic variation linked to HPA axis (10 single nucleotide polymorphisms [SNPs]) and serotonergic (five SNPs) functioning. Results showed significant MGPS × Childhood Adversity × Recent Life Stress interactions predicting depression for both HPA axis and serotonergic MGPSs, with both risk scores predicting stronger Childhood Adversity × Recent Stress interactions. Serotonergic genetic risk specifically predicted sensitization to major interpersonal stressors. The serotonergic MGPS G × E × E was re-tested in an independent replication sample of early adolescent girls, with comparable results. Findings support the notion that genetic variation linked to these two neurobiological symptoms alters stress sensitization, and that gene-by-environment (G × E) interactions may be qualified by environmental exposures occurring at different points in development. En ligne : http://dx.doi.org/10.1017/S0954579420000474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 The moderating effects of traumatic stress on vulnerability to emotional distress during pregnancy / Irene TUNG in Development and Psychopathology, 32-2 (May 2020)
[article]
Titre : The moderating effects of traumatic stress on vulnerability to emotional distress during pregnancy Type de document : Texte imprimé et/ou numérique Auteurs : Irene TUNG, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur ; Alison E. HIPWELL, Auteur Article en page(s) : p.673-686 Langues : Anglais (eng) Mots-clés : adverse childhood experiences early adversity intimate partner violence pregnancy stress stress sensitization Index. décimale : PER Périodiques Résumé : Emotional distress during pregnancy is likely influenced by both maternal history of adversity and concurrent prenatal stressors, but prospective longitudinal studies are lacking. Guided by a life span model of pregnancy health and stress sensitization theories, this study investigated the influence of intimate partner violence (IPV) during pregnancy on the association between childhood adversity and prenatal emotional distress. Participants included an urban, community-based sample of 200 pregnant women (aged 18-24) assessed annually from ages 8 to 17 for a range of adversity domains, including traumatic violence, harsh parenting, caregiver loss, and compromised parenting. Models tested both linear and nonlinear effects of adversity as well as their interactions with IPV on prenatal anxiety and depression symptoms, controlling for potential confounds such as poverty and childhood anxiety and depression. Results showed that the associations between childhood adversity and pregnancy emotional distress were moderated by prenatal IPV, supporting a life span conceptualization of pregnancy health. Patterns of interactions were nonlinear, consistent with theories conceptualizing stress sensitization through an "adaptive calibration" lens. Furthermore, results diverged based on adversity subdomain and type of prenatal IPV (physical vs. emotional abuse). Findings are discussed in the context of existing stress sensitization theories and highlight important avenues for future research and practice. En ligne : http://dx.doi.org/10.1017/s0954579419000531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Development and Psychopathology > 32-2 (May 2020) . - p.673-686[article] The moderating effects of traumatic stress on vulnerability to emotional distress during pregnancy [Texte imprimé et/ou numérique] / Irene TUNG, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur ; Alison E. HIPWELL, Auteur . - p.673-686.
Langues : Anglais (eng)
in Development and Psychopathology > 32-2 (May 2020) . - p.673-686
Mots-clés : adverse childhood experiences early adversity intimate partner violence pregnancy stress stress sensitization Index. décimale : PER Périodiques Résumé : Emotional distress during pregnancy is likely influenced by both maternal history of adversity and concurrent prenatal stressors, but prospective longitudinal studies are lacking. Guided by a life span model of pregnancy health and stress sensitization theories, this study investigated the influence of intimate partner violence (IPV) during pregnancy on the association between childhood adversity and prenatal emotional distress. Participants included an urban, community-based sample of 200 pregnant women (aged 18-24) assessed annually from ages 8 to 17 for a range of adversity domains, including traumatic violence, harsh parenting, caregiver loss, and compromised parenting. Models tested both linear and nonlinear effects of adversity as well as their interactions with IPV on prenatal anxiety and depression symptoms, controlling for potential confounds such as poverty and childhood anxiety and depression. Results showed that the associations between childhood adversity and pregnancy emotional distress were moderated by prenatal IPV, supporting a life span conceptualization of pregnancy health. Patterns of interactions were nonlinear, consistent with theories conceptualizing stress sensitization through an "adaptive calibration" lens. Furthermore, results diverged based on adversity subdomain and type of prenatal IPV (physical vs. emotional abuse). Findings are discussed in the context of existing stress sensitization theories and highlight important avenues for future research and practice. En ligne : http://dx.doi.org/10.1017/s0954579419000531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426