6 recherche sur le mot-clé 'ultrasound'

A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism / Lisa M. UNWIN in Autism Research, 9-2 (February 2016)  

Public ISBD [article]  inAutism Research > 9-2 (February 2016) . - p.210-216 Titre : A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism Type de document : texte imprimé Auteurs : Lisa M. UNWIN, Auteur ; Murray T. MAYBERY, Auteur ; Anthony MURPHY, Auteur ; Wendy LILJE, Auteur ; Michelle BELLESINI, Auteur ; Anna HUNT, Auteur ; Joanna GRANICH, Auteur ; Peter JACOBY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Craig E. PENNELL, Auteur ; Martha HICKEY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.210-216 Langues : Anglais (eng) Mots-clés : infants  pediatrics  developmental psychology  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Numerous studies have observed that a proportion of infants later diagnosed with autism spectrum disorder (ASD) experience accelerated head growth during the first years of life. An emerging methodology for examining the developmental trajectory prior to a diagnosis of ASD is to investigate siblings of affected individuals. The current study is the first prospective investigation of fetal growth in siblings of children with ASD. Two groups of pregnant women were recruited as part of the PRegnancy Investigation of Siblings and Mothers of children with autism cohort in Perth, Western Australia. The “high risk” group (n = 23) comprised pregnant women who have an existing child with a diagnosis of ASD and the “low risk” group (n = 36) comprised pregnant mothers who have an existing child who has developed typically. Prenatal ultrasounds were procured at multiple time-points throughout the second- and third-trimesters, enabling an examination of growth trajectories. Growth measurements were then compared for the high- and low-risk fetuses. Mixed linear regression models identified no significant differences between the high- and low-risk fetuses in the rate of prenatal head and body growth throughout the second- and third-trimester (all P-values >0.05). Similarly, there were no significant differences observed when comparing high and low risk groups on a ratio of head circumference relative to body size (β = −0.019, P = 0.75). Future studies may consider looking beyond the macro architecture of the prenatal brain and examine the growth of brain subregions that have been implicated in the presentation of ASD symptoms. En ligne : http://dx.doi.org/10.1002/aur.1518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism [texte imprimé] / Lisa M. UNWIN, Auteur ; Murray T. MAYBERY, Auteur ; Anthony MURPHY, Auteur ; Wendy LILJE, Auteur ; Michelle BELLESINI, Auteur ; Anna HUNT, Auteur ; Joanna GRANICH, Auteur ; Peter JACOBY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Craig E. PENNELL, Auteur ; Martha HICKEY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.210-216. Langues : Anglais (eng) in Autism Research > 9-2 (February 2016) . - p.210-216 Mots-clés : infants  pediatrics  developmental psychology  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Numerous studies have observed that a proportion of infants later diagnosed with autism spectrum disorder (ASD) experience accelerated head growth during the first years of life. An emerging methodology for examining the developmental trajectory prior to a diagnosis of ASD is to investigate siblings of affected individuals. The current study is the first prospective investigation of fetal growth in siblings of children with ASD. Two groups of pregnant women were recruited as part of the PRegnancy Investigation of Siblings and Mothers of children with autism cohort in Perth, Western Australia. The “high risk” group (n = 23) comprised pregnant women who have an existing child with a diagnosis of ASD and the “low risk” group (n = 36) comprised pregnant mothers who have an existing child who has developed typically. Prenatal ultrasounds were procured at multiple time-points throughout the second- and third-trimesters, enabling an examination of growth trajectories. Growth measurements were then compared for the high- and low-risk fetuses. Mixed linear regression models identified no significant differences between the high- and low-risk fetuses in the rate of prenatal head and body growth throughout the second- and third-trimester (all P-values >0.05). Similarly, there were no significant differences observed when comparing high and low risk groups on a ratio of head circumference relative to body size (β = −0.019, P = 0.75). Future studies may consider looking beyond the macro architecture of the prenatal brain and examine the growth of brain subregions that have been implicated in the presentation of ASD symptoms. En ligne : http://dx.doi.org/10.1002/aur.1518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound / Sara Jane WEBB in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.472-484 Titre : Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound Type de document : texte imprimé Auteurs : Sara Jane WEBB, Auteur ; Michelle M. GARRISON, Auteur ; Raphael A. BERNIER, Auteur ; Abbi M. MCCLINTIC, Auteur ; Bryan H. KING, Auteur ; Pierre D. MOURAD, Auteur Article en page(s) : p.472-484 Langues : Anglais (eng) Mots-clés : epidemiology  genetics  environmental influences  ASD severity  ultrasound Index. décimale : PER Périodiques Résumé : Current research suggests that incidence and heterogeneity of autism spectrum disorder (ASD) symptoms may arise through a variety of exogenous and/or endogenous factors. While subject to routine clinical practice and generally considered safe, there exists speculation, though no human data, that diagnostic ultrasound may also contribute to ASD severity, supported by experimental evidence that exposure to ultrasound early in gestation could perturb brain development and alter behavior. Here we explored a modified triple hit hypothesis [Williams & Casanova, ] to assay for a possible relationship between the severity of ASD symptoms and (1) ultrasound exposure (2) during the first trimester of pregnancy in fetuses with a (3) genetic predisposition to ASD. We did so using retrospective analysis of data from the SSC (Simon's Simplex Collection) autism genetic repository funded by the Simons Foundation Autism Research Initiative. We found that male children with ASD, copy number variations (CNVs), and exposure to first trimester ultrasound had significantly decreased non-verbal IQ and increased repetitive behaviors relative to male children with ASD, with CNVs, and no ultrasound. These data suggest that heterogeneity in ASD symptoms may result, at least in part, from exposure to diagnostic ultrasound during early prenatal development of children with specific genetic vulnerabilities. These results also add weight to on-going concerns expressed by the FDA about non-medical use of diagnostic ultrasound during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1690 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound [texte imprimé] / Sara Jane WEBB, Auteur ; Michelle M. GARRISON, Auteur ; Raphael A. BERNIER, Auteur ; Abbi M. MCCLINTIC, Auteur ; Bryan H. KING, Auteur ; Pierre D. MOURAD, Auteur . - p.472-484. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.472-484 Mots-clés : epidemiology  genetics  environmental influences  ASD severity  ultrasound Index. décimale : PER Périodiques Résumé : Current research suggests that incidence and heterogeneity of autism spectrum disorder (ASD) symptoms may arise through a variety of exogenous and/or endogenous factors. While subject to routine clinical practice and generally considered safe, there exists speculation, though no human data, that diagnostic ultrasound may also contribute to ASD severity, supported by experimental evidence that exposure to ultrasound early in gestation could perturb brain development and alter behavior. Here we explored a modified triple hit hypothesis [Williams & Casanova, ] to assay for a possible relationship between the severity of ASD symptoms and (1) ultrasound exposure (2) during the first trimester of pregnancy in fetuses with a (3) genetic predisposition to ASD. We did so using retrospective analysis of data from the SSC (Simon's Simplex Collection) autism genetic repository funded by the Simons Foundation Autism Research Initiative. We found that male children with ASD, copy number variations (CNVs), and exposure to first trimester ultrasound had significantly decreased non-verbal IQ and increased repetitive behaviors relative to male children with ASD, with CNVs, and no ultrasound. These data suggest that heterogeneity in ASD symptoms may result, at least in part, from exposure to diagnostic ultrasound during early prenatal development of children with specific genetic vulnerabilities. These results also add weight to on-going concerns expressed by the FDA about non-medical use of diagnostic ultrasound during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1690 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Autism is a prenatal disorder: Evidence from late gestation brain overgrowth / Frédérique BONNET-BRILHAULT in Autism Research, 11-12 (December 2018)  

Public ISBD [article]  inAutism Research > 11-12 (December 2018) . - p.1635-1642 Titre : Autism is a prenatal disorder: Evidence from late gestation brain overgrowth Type de document : texte imprimé Auteurs : Frédérique BONNET-BRILHAULT, Auteur ; Toky A. RAJERISON, Auteur ; Christian PAILLET, Auteur ; Marie GUIMARD-BRUNAULT, Auteur ; Agathe SABY, Auteur ; Laura PONSON, Auteur ; Gabriele TRIPI, Auteur ; Joëlle MALVY, Auteur ; Sylvie ROUX, Auteur Article en page(s) : p.1635-1642 Langues : Anglais (eng) Mots-clés : brain growth  head circumference  neurodevelopmental disorder  ultrasound Index. décimale : PER Périodiques Résumé : This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. Autism Research 2018, 11: 1635-1642. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is now widely acknowledged in the scientific community, that autism is a neurodevelopmental disorder. Recent evidence from animal and pathological studies has implicated the in utero period. However, the precise time of onset of abnormal brain development remains unknown. This retrospective study reports novel findings, identifying an atypical head growth trajectory in children with autism, during the in utero period (after the 22nd week of amenorrhea). In the same children, postnatal head overgrowth was also observed. Late gestation is identified as a critical period for atypical brain development underlying autism symptoms. En ligne : http://dx.doi.org/10.1002/aur.2036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372 [article] Autism is a prenatal disorder: Evidence from late gestation brain overgrowth [texte imprimé] / Frédérique BONNET-BRILHAULT, Auteur ; Toky A. RAJERISON, Auteur ; Christian PAILLET, Auteur ; Marie GUIMARD-BRUNAULT, Auteur ; Agathe SABY, Auteur ; Laura PONSON, Auteur ; Gabriele TRIPI, Auteur ; Joëlle MALVY, Auteur ; Sylvie ROUX, Auteur . - p.1635-1642. Langues : Anglais (eng) in Autism Research > 11-12 (December 2018) . - p.1635-1642 Mots-clés : brain growth  head circumference  neurodevelopmental disorder  ultrasound Index. décimale : PER Périodiques Résumé : This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. Autism Research 2018, 11: 1635-1642. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is now widely acknowledged in the scientific community, that autism is a neurodevelopmental disorder. Recent evidence from animal and pathological studies has implicated the in utero period. However, the precise time of onset of abnormal brain development remains unknown. This retrospective study reports novel findings, identifying an atypical head growth trajectory in children with autism, during the in utero period (after the 22nd week of amenorrhea). In the same children, postnatal head overgrowth was also observed. Late gestation is identified as a critical period for atypical brain development underlying autism symptoms. En ligne : http://dx.doi.org/10.1002/aur.2036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372

Fetal brain growth and infant autistic traits / Ezra AYDIN in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 11p. Titre : Fetal brain growth and infant autistic traits Type de document : texte imprimé Auteurs : Ezra AYDIN, Auteur ; Alex TSOMPANIDIS, Auteur ; Daren CHAPLIN, Auteur ; Rebecca HAWKES, Auteur ; Carrie ALLISON, Auteur ; Gerald HACKETT, Auteur ; Topun AUSTIN, Auteur ; Eglė PADAIGAITĖ, Auteur ; Lidia V. GABIS, Auteur ; John SUCKING, Auteur ; Rosemary J. HOLT, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 11p. Langues : Anglais (eng) Mots-clés : Male  Infant  Pregnancy  Female  Humans  Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  Gestational Age  Autistic traits  Early brain development  Q-chat  Transcerebellar diameter  Ultrasound Index. décimale : PER Périodiques Résumé : BACKGROUND: Structural differences exist in the brains of autistic individuals. To date only a few studies have explored the relationship between fetal brain growth and later infant autistic traits, and some have used fetal head circumference (HC) as a proxy for brain development. These findings have been inconsistent. Here we investigate whether fetal subregional brain measurements correlate with autistic traits in toddlers. METHODS: A total of 219 singleton pregnancies (104 males and 115 females) were recruited at the Rosie Hospital, Cambridge, UK. 2D ultrasound was performed at 12-, 20- and between 26 and 30 weeks of pregnancy, measuring head circumference (HC), ventricular atrium (VA) and transcerebellar diameter (TCD). A total of 179 infants were followed up at 18-20 months of age and completed the quantitative checklist for autism in toddlers (Q-CHAT) to measure autistic traits. RESULTS: Q-CHAT scores at 18-20 months of age were positively associated with TCD size at 20 weeks and with HC at 28 weeks, in univariate analyses, and in multiple regression models which controlled for sex, maternal age and birth weight. LIMITATIONS: Due to the nature and location of the study, ascertainment bias could also have contributed to the recruitment of volunteer mothers with a higher than typical range of autistic traits and/or with a significant interest in the neurodevelopment of their children. CONCLUSION: Prenatal brain growth is associated with toddler autistic traits and this can be ascertained via ultrasound starting at 20 weeks gestation. En ligne : https://dx.doi.org/10.1186/s13229-024-00586-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Fetal brain growth and infant autistic traits [texte imprimé] / Ezra AYDIN, Auteur ; Alex TSOMPANIDIS, Auteur ; Daren CHAPLIN, Auteur ; Rebecca HAWKES, Auteur ; Carrie ALLISON, Auteur ; Gerald HACKETT, Auteur ; Topun AUSTIN, Auteur ; Eglė PADAIGAITĖ, Auteur ; Lidia V. GABIS, Auteur ; John SUCKING, Auteur ; Rosemary J. HOLT, Auteur ; Simon BARON-COHEN, Auteur . - 11p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 11p. Mots-clés : Male  Infant  Pregnancy  Female  Humans  Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  Gestational Age  Autistic traits  Early brain development  Q-chat  Transcerebellar diameter  Ultrasound Index. décimale : PER Périodiques Résumé : BACKGROUND: Structural differences exist in the brains of autistic individuals. To date only a few studies have explored the relationship between fetal brain growth and later infant autistic traits, and some have used fetal head circumference (HC) as a proxy for brain development. These findings have been inconsistent. Here we investigate whether fetal subregional brain measurements correlate with autistic traits in toddlers. METHODS: A total of 219 singleton pregnancies (104 males and 115 females) were recruited at the Rosie Hospital, Cambridge, UK. 2D ultrasound was performed at 12-, 20- and between 26 and 30 weeks of pregnancy, measuring head circumference (HC), ventricular atrium (VA) and transcerebellar diameter (TCD). A total of 179 infants were followed up at 18-20 months of age and completed the quantitative checklist for autism in toddlers (Q-CHAT) to measure autistic traits. RESULTS: Q-CHAT scores at 18-20 months of age were positively associated with TCD size at 20 weeks and with HC at 28 weeks, in univariate analyses, and in multiple regression models which controlled for sex, maternal age and birth weight. LIMITATIONS: Due to the nature and location of the study, ascertainment bias could also have contributed to the recruitment of volunteer mothers with a higher than typical range of autistic traits and/or with a significant interest in the neurodevelopment of their children. CONCLUSION: Prenatal brain growth is associated with toddler autistic traits and this can be ascertained via ultrasound starting at 20 weeks gestation. En ligne : https://dx.doi.org/10.1186/s13229-024-00586-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder / Andrew J.O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.122-129 Titre : Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Andrew J.O. WHITEHOUSE, Auteur ; Martha HICKEY, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur ; Craig E. PENNELL, Auteur Année de publication : 2011 Article en page(s) : p.122-129 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain growth  Head circumference  Fetus  Ultrasound Index. décimale : PER Périodiques Résumé : Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-010-1019-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder [texte imprimé] / Andrew J.O. WHITEHOUSE, Auteur ; Martha HICKEY, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur ; Craig E. PENNELL, Auteur . - 2011 . - p.122-129. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.122-129 Mots-clés : Autism spectrum disorder  Brain growth  Head circumference  Fetus  Ultrasound Index. décimale : PER Périodiques Résumé : Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-010-1019-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

A prospective study of fetal head growth, autistic traits and autism spectrum disorder / Laura M.E. BLANKEN in Autism Research, 11-4 (April 2018)  

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