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Vitamin D in the General Population of Young Adults with Autism in the Faroe Islands / Eva KOCOVSKA in Journal of Autism and Developmental Disorders, 44-12 (December 2014)
[article]
Titre : Vitamin D in the General Population of Young Adults with Autism in the Faroe Islands Type de document : Texte imprimé et/ou numérique Auteurs : Eva KOCOVSKA, Auteur ; Guðrið ANDORSDÓTTIR, Auteur ; Pál WEIHE, Auteur ; Jónrit HALLING, Auteur ; Elisabeth FERNELL, Auteur ; Tormóður STORA, Auteur ; Rannvá BISKUPSTØ, Auteur ; I. Carina GILLBERG, Auteur ; Robyn SHEA, Auteur ; Eva BILLSTEDT, Auteur ; Thomas BOURGERON, Auteur ; Helen MINNIS, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.2996-3005 Langues : Anglais (eng) Mots-clés : Autism ASD Vitamin D Calcitriol Total population Faroe Islands Index. décimale : PER Périodiques Résumé : Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15–24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism. En ligne : http://dx.doi.org/10.1007/s10803-014-2155-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.2996-3005[article] Vitamin D in the General Population of Young Adults with Autism in the Faroe Islands [Texte imprimé et/ou numérique] / Eva KOCOVSKA, Auteur ; Guðrið ANDORSDÓTTIR, Auteur ; Pál WEIHE, Auteur ; Jónrit HALLING, Auteur ; Elisabeth FERNELL, Auteur ; Tormóður STORA, Auteur ; Rannvá BISKUPSTØ, Auteur ; I. Carina GILLBERG, Auteur ; Robyn SHEA, Auteur ; Eva BILLSTEDT, Auteur ; Thomas BOURGERON, Auteur ; Helen MINNIS, Auteur ; Christopher GILLBERG, Auteur . - p.2996-3005.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.2996-3005
Mots-clés : Autism ASD Vitamin D Calcitriol Total population Faroe Islands Index. décimale : PER Périodiques Résumé : Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15–24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism. En ligne : http://dx.doi.org/10.1007/s10803-014-2155-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder / Franca Rosa GUERINI in Autism Research, 13-5 (May 2020)
[article]
Titre : Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Franca Rosa GUERINI, Auteur ; Elisabetta BOLOGNESI, Auteur ; Matteo CHIAPPEDI, Auteur ; Maria Martina MENSI, Auteur ; Oscar FUMAGALLI, Auteur ; Chiara ROGANTINI, Auteur ; Milena ZANZOTTERA, Auteur ; Alessandro GHEZZO, Auteur ; Michela ZANETTE, Auteur ; Cristina AGLIARDI, Auteur ; Andrea Saul COSTA, Auteur ; Stefano SOTGIU, Auteur ; Alessandra CARTA, Auteur ; Nasser AL DAGHRI, Auteur ; Mario CLERICI, Auteur Article en page(s) : p.680-690 Langues : Anglais (eng) Mots-clés : Autistic Spectrum Disorder Immune system, VDR FokI VDR polymorphisms Vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D is endowed with a number of biological properties, including down-regulation of inflammation, and might contribute to the pathogenesis of autism spectrum disorders (ASD). Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. We evaluated such Single Nucletoide Polymorphismsm (SNPs) in a cohort of 100 Italian families with ASD children. FokI genotype distribution was skewed in ASD children compared with their healthy sibs (Pc = 0.03 2 df) and to a group of 170 Italian healthy women (HC) (Pc = 0.04 2 df). FokI genotype and allelic distribution skewing were also observed in mothers of ASD children compared to HC (Pc = 0.04 2 df). Both Transmission Disequilibrium Test for single loci and haplotype analysis distribution revealed a major FokI (C) allele-mediated protective effect, which was more frequently transmitted (73%) than not transmitted to healthy sibs (P = 0.02). A protective FokI-, BsmI-, ApaI-, and TaqI (CCAG) haplotype was more frequently carried by healthy sibs than by ASD children (P = 1 x 10(-4) ; OR: 0.1, 95% CI: 0.03-0.4) too. Finally, a strong gene-dose association of FokI (T) allele with both higher Childhood Autism Rating Scale score (Pc = 0.01) and, particularly, with hyperactivity behavior (Pc = 0.006) emerged in ASD children. Because the protein produced by the FokI (T) allele is transcriptionally less active than that produced by the FokI (C) allele, the reduced biological activity of the vitamin D/VDR complex prevalent in ASD could favor ASD- and maternal immune activation- associated inflammation. Vitamin D supplementation might be useful in preventative and rehabilitation protocols for ASD. Autism Res 2020, 13: 680-690. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Vitamin D deficiency and Vitamin D receptor (VDR) polymorphisms are associated with structural and functional brain abnormalities and behavioral disorders. We analyzed the association of VDR gene polymorphisms in a cohort of 100 Italian families with ASD children. A strong correlation between one of the VDR polymorphisms and hyperactivity behavior was evidenced in ASD children. In healthy mothers, the same VDR polymorphism was also correlated with an increased risk of giving birth to children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Autism Research > 13-5 (May 2020) . - p.680-690[article] Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Franca Rosa GUERINI, Auteur ; Elisabetta BOLOGNESI, Auteur ; Matteo CHIAPPEDI, Auteur ; Maria Martina MENSI, Auteur ; Oscar FUMAGALLI, Auteur ; Chiara ROGANTINI, Auteur ; Milena ZANZOTTERA, Auteur ; Alessandro GHEZZO, Auteur ; Michela ZANETTE, Auteur ; Cristina AGLIARDI, Auteur ; Andrea Saul COSTA, Auteur ; Stefano SOTGIU, Auteur ; Alessandra CARTA, Auteur ; Nasser AL DAGHRI, Auteur ; Mario CLERICI, Auteur . - p.680-690.
Langues : Anglais (eng)
in Autism Research > 13-5 (May 2020) . - p.680-690
Mots-clés : Autistic Spectrum Disorder Immune system, VDR FokI VDR polymorphisms Vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D is endowed with a number of biological properties, including down-regulation of inflammation, and might contribute to the pathogenesis of autism spectrum disorders (ASD). Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. We evaluated such Single Nucletoide Polymorphismsm (SNPs) in a cohort of 100 Italian families with ASD children. FokI genotype distribution was skewed in ASD children compared with their healthy sibs (Pc = 0.03 2 df) and to a group of 170 Italian healthy women (HC) (Pc = 0.04 2 df). FokI genotype and allelic distribution skewing were also observed in mothers of ASD children compared to HC (Pc = 0.04 2 df). Both Transmission Disequilibrium Test for single loci and haplotype analysis distribution revealed a major FokI (C) allele-mediated protective effect, which was more frequently transmitted (73%) than not transmitted to healthy sibs (P = 0.02). A protective FokI-, BsmI-, ApaI-, and TaqI (CCAG) haplotype was more frequently carried by healthy sibs than by ASD children (P = 1 x 10(-4) ; OR: 0.1, 95% CI: 0.03-0.4) too. Finally, a strong gene-dose association of FokI (T) allele with both higher Childhood Autism Rating Scale score (Pc = 0.01) and, particularly, with hyperactivity behavior (Pc = 0.006) emerged in ASD children. Because the protein produced by the FokI (T) allele is transcriptionally less active than that produced by the FokI (C) allele, the reduced biological activity of the vitamin D/VDR complex prevalent in ASD could favor ASD- and maternal immune activation- associated inflammation. Vitamin D supplementation might be useful in preventative and rehabilitation protocols for ASD. Autism Res 2020, 13: 680-690. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Vitamin D deficiency and Vitamin D receptor (VDR) polymorphisms are associated with structural and functional brain abnormalities and behavioral disorders. We analyzed the association of VDR gene polymorphisms in a cohort of 100 Italian families with ASD children. A strong correlation between one of the VDR polymorphisms and hyperactivity behavior was evidenced in ASD children. In healthy mothers, the same VDR polymorphism was also correlated with an increased risk of giving birth to children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study / Rebecca J. SCHMIDT in Autism Research, 12-6 (June 2019)
[article]
Titre : Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca J. SCHMIDT, Auteur ; Q. NIU, Auteur ; D. W. EYLES, Auteur ; R. L. HANSEN, Auteur ; A. M. IOSIF, Auteur Année de publication : 2019 Article en page(s) : p.976-988 Langues : Anglais (eng) Mots-clés : Down syndrome autism spectrum disorder child development disorders infant newborn prevention vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D appears essential for normal neurodevelopment and cognitive and behavioral function. We examined neonatal vitamin D in relation to the child's later diagnosis of autism spectrum disorder (ASD) or developmental delay (DD). Children aged 24-60 months enrolled in the population-based CHARGE case-control study were evaluated clinically for ASD (n = 357), DD (n = 134), or typical development (TD, n = 234) at the MIND Institute (Sacramento, CA) using standardized assessments. Total 25-hydroxyvitamin D (25[OH]D) was measured using sensitive isotope dilution liquid chromatography-tandem mass spectrometry in archived dried blood spots collected for the California Department of Public Health's Newborn Screening Program. Multinomial logistic regression was used to calculate ORs as measures of the associations between 25 nmol/L change in 25(OH)D and ASD and DD. Associations between 25(OH)D and scores on Mullen Scales of Early Learning and Vineland Adaptive Behavior Scales were assessed using robust linear regression. Effect modification was examined using stratified models and interaction product terms. Unadjusted mean (SD) 25(OH)D was lower for DD (73.2 [37.6]) than for TD (82.7 [39.3]) and ASD (80.1 [37.4]). After adjustment for maternal prepregnancy body mass index and education, a 25 nmol/L increase in total 25(OH)D was not associated with ASD (OR = 0.97; CI: 0.87-1.08) or DD (OR = 0.91; 95% CI: 0.78-1.06). Neonatal 25(OH)D was associated with significantly reduced ASD only in females (adjusted OR = 0.74; 95% CI: 0.55-0.99, Pinteraction = 0.03), and significantly reduced DD only in non-Hispanic white children (adjusted OR = 0.79; 95% CI: 0.63-0.98, Pinteraction = 0.11 for Hispanic, Pinteraction = 0.31 for other), driven by DD children with trisomy 21. This study provides evidence that neonatal vitamin D could be associated with ASD in females and with DD in non-Hispanic white children. Autism Res 2019, 12: 976-988. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Vitamin D appears essential for brain development and function. We examined neonatal total 25-hydroxyvitamin D (25[OH]D) measured in dried blood spots in relation to later diagnoses of autism spectrum disorder (ASD) or developmental delay (DD) and related assessment scores. Higher neonatal 25(OH)D was associated with a 26% reduction in the odds for ASD only in females. After taking into account factors that could contribute to vitamin D status, a significant association with 21% reduced odds for DD was found only in non-Hispanic white children. Though results were nonsignificant overall, certain subgroups might benefit from higher neonatal vitamin D. En ligne : https://dx.doi.org/10.1002/aur.2118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400
in Autism Research > 12-6 (June 2019) . - p.976-988[article] Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study [Texte imprimé et/ou numérique] / Rebecca J. SCHMIDT, Auteur ; Q. NIU, Auteur ; D. W. EYLES, Auteur ; R. L. HANSEN, Auteur ; A. M. IOSIF, Auteur . - 2019 . - p.976-988.
Langues : Anglais (eng)
in Autism Research > 12-6 (June 2019) . - p.976-988
Mots-clés : Down syndrome autism spectrum disorder child development disorders infant newborn prevention vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D appears essential for normal neurodevelopment and cognitive and behavioral function. We examined neonatal vitamin D in relation to the child's later diagnosis of autism spectrum disorder (ASD) or developmental delay (DD). Children aged 24-60 months enrolled in the population-based CHARGE case-control study were evaluated clinically for ASD (n = 357), DD (n = 134), or typical development (TD, n = 234) at the MIND Institute (Sacramento, CA) using standardized assessments. Total 25-hydroxyvitamin D (25[OH]D) was measured using sensitive isotope dilution liquid chromatography-tandem mass spectrometry in archived dried blood spots collected for the California Department of Public Health's Newborn Screening Program. Multinomial logistic regression was used to calculate ORs as measures of the associations between 25 nmol/L change in 25(OH)D and ASD and DD. Associations between 25(OH)D and scores on Mullen Scales of Early Learning and Vineland Adaptive Behavior Scales were assessed using robust linear regression. Effect modification was examined using stratified models and interaction product terms. Unadjusted mean (SD) 25(OH)D was lower for DD (73.2 [37.6]) than for TD (82.7 [39.3]) and ASD (80.1 [37.4]). After adjustment for maternal prepregnancy body mass index and education, a 25 nmol/L increase in total 25(OH)D was not associated with ASD (OR = 0.97; CI: 0.87-1.08) or DD (OR = 0.91; 95% CI: 0.78-1.06). Neonatal 25(OH)D was associated with significantly reduced ASD only in females (adjusted OR = 0.74; 95% CI: 0.55-0.99, Pinteraction = 0.03), and significantly reduced DD only in non-Hispanic white children (adjusted OR = 0.79; 95% CI: 0.63-0.98, Pinteraction = 0.11 for Hispanic, Pinteraction = 0.31 for other), driven by DD children with trisomy 21. This study provides evidence that neonatal vitamin D could be associated with ASD in females and with DD in non-Hispanic white children. Autism Res 2019, 12: 976-988. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Vitamin D appears essential for brain development and function. We examined neonatal total 25-hydroxyvitamin D (25[OH]D) measured in dried blood spots in relation to later diagnoses of autism spectrum disorder (ASD) or developmental delay (DD) and related assessment scores. Higher neonatal 25(OH)D was associated with a 26% reduction in the odds for ASD only in females. After taking into account factors that could contribute to vitamin D status, a significant association with 21% reduced odds for DD was found only in non-Hispanic white children. Though results were nonsignificant overall, certain subgroups might benefit from higher neonatal vitamin D. En ligne : https://dx.doi.org/10.1002/aur.2118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california / G. C. WINDHAM in Autism Research, 12-6 (June 2019)
[article]
Titre : Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california Type de document : Texte imprimé et/ou numérique Auteurs : G. C. WINDHAM, Auteur ; M. PEARL, Auteur ; M. C. ANDERSON, Auteur ; V. POON, Auteur ; D. EYLES, Auteur ; K. L. JONES, Auteur ; K. LYALL, Auteur ; M. KHARRAZI, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2019 Article en page(s) : p.989-998 Langues : Anglais (eng) Mots-clés : Asd autism hydroxy-vitamin D intellectual disability vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Children with ASD (N = 563) or intellectual disability (ID) (N = 190) were identified from the Department of Developmental Services and compared to population controls (N = 436) identified from birth certificates. 25-hydroxyvitamin D (25(OH)D) was measured in archived newborn dried blood spots by a sensitive assay and corrected to sera equivalents. We categorized 25(OH) D levels as deficient (<50 nmol/L), insufficient (50-74 nmol/L), and sufficient (>/=75 nmol/L), and also examined continuous levels, using logistic regression. The adjusted odds ratios (AOR) and 95% confidence intervals for ASD were 0.96 (0.64-1.4) for 25(OH)D deficiency (14% of newborns) and 1.2 (0.86-1.6) for insufficiency (26% of newborns). The AORs for continuous 25(OH)D (per 25 nmol/L) were 1.0 (0.91-1.09) for ASD and 1.14 (1.0-1.30) for ID. Thus, in this relatively large study of measured newborn vitamin D levels, our results do not support the hypothesis of lower 25(OH)D being associated with higher risk of ASD (or ID), although we observed suggestion of interactions with sex and race/ethnicity. 25(OH)D levels were relatively high (median 84 nmol/L in controls), so results may differ in populations with higher prevalence of low vitamin D levels. Autism Res 2019, 12: 989-998. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We studied whether vitamin D levels measured at birth were related to whether a child later developed autism (or low IQ). Our results did not show that children with autism, or low IQ, overall had lower vitamin D levels at birth than children without autism. Vitamin D levels were fairly high, on average, in these children born in Southern California. En ligne : https://dx.doi.org/10.1002/aur.2092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Autism Research > 12-6 (June 2019) . - p.989-998[article] Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california [Texte imprimé et/ou numérique] / G. C. WINDHAM, Auteur ; M. PEARL, Auteur ; M. C. ANDERSON, Auteur ; V. POON, Auteur ; D. EYLES, Auteur ; K. L. JONES, Auteur ; K. LYALL, Auteur ; M. KHARRAZI, Auteur ; Lisa A. CROEN, Auteur . - 2019 . - p.989-998.
Langues : Anglais (eng)
in Autism Research > 12-6 (June 2019) . - p.989-998
Mots-clés : Asd autism hydroxy-vitamin D intellectual disability vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Children with ASD (N = 563) or intellectual disability (ID) (N = 190) were identified from the Department of Developmental Services and compared to population controls (N = 436) identified from birth certificates. 25-hydroxyvitamin D (25(OH)D) was measured in archived newborn dried blood spots by a sensitive assay and corrected to sera equivalents. We categorized 25(OH) D levels as deficient (<50 nmol/L), insufficient (50-74 nmol/L), and sufficient (>/=75 nmol/L), and also examined continuous levels, using logistic regression. The adjusted odds ratios (AOR) and 95% confidence intervals for ASD were 0.96 (0.64-1.4) for 25(OH)D deficiency (14% of newborns) and 1.2 (0.86-1.6) for insufficiency (26% of newborns). The AORs for continuous 25(OH)D (per 25 nmol/L) were 1.0 (0.91-1.09) for ASD and 1.14 (1.0-1.30) for ID. Thus, in this relatively large study of measured newborn vitamin D levels, our results do not support the hypothesis of lower 25(OH)D being associated with higher risk of ASD (or ID), although we observed suggestion of interactions with sex and race/ethnicity. 25(OH)D levels were relatively high (median 84 nmol/L in controls), so results may differ in populations with higher prevalence of low vitamin D levels. Autism Res 2019, 12: 989-998. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We studied whether vitamin D levels measured at birth were related to whether a child later developed autism (or low IQ). Our results did not show that children with autism, or low IQ, overall had lower vitamin D levels at birth than children without autism. Vitamin D levels were fairly high, on average, in these children born in Southern California. En ligne : https://dx.doi.org/10.1002/aur.2092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia / Subhashini JAYANATH in Research in Autism Spectrum Disorders, 84 (June 2021)
[article]
Titre : Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia Type de document : Texte imprimé et/ou numérique Auteurs : Subhashini JAYANATH, Auteur ; Choong Yi FONG, Auteur ; Rajini SARVANANTHAN, Auteur Article en page(s) : 101786 Langues : Anglais (eng) Mots-clés : Autism Vitamin D Children Childhood Autism Rating Scale Aberrant Behaviour Checklist Index. décimale : PER Périodiques Résumé : Background Determine the prevalence and risk factors of vitamin D deficiency (<35?nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0?nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results There were 103 participants (85.4 % male). Mean age: 6.2 years (SD?=?2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8?nmol/L (SD?=?13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p?=?0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p?0.05), but not ABC-2 scores. Conclusions Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms. En ligne : https://doi.org/10.1016/j.rasd.2021.101786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446
in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101786[article] Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia [Texte imprimé et/ou numérique] / Subhashini JAYANATH, Auteur ; Choong Yi FONG, Auteur ; Rajini SARVANANTHAN, Auteur . - 101786.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101786
Mots-clés : Autism Vitamin D Children Childhood Autism Rating Scale Aberrant Behaviour Checklist Index. décimale : PER Périodiques Résumé : Background Determine the prevalence and risk factors of vitamin D deficiency (<35?nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0?nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results There were 103 participants (85.4 % male). Mean age: 6.2 years (SD?=?2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8?nmol/L (SD?=?13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p?=?0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p?0.05), but not ABC-2 scores. Conclusions Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms. En ligne : https://doi.org/10.1016/j.rasd.2021.101786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446 Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study / Paul MADLEY-DOWD in Molecular Autism, 13 (2022)
PermalinkMaternal Vitamin D Levels and the Autism Phenotype Among Offspring / Andrew J. O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 43-7 (July 2013)
PermalinkMaternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups / Gayle C. WINDHAM in Autism Research, 13-12 (December 2020)
PermalinkProspective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood / Yamna ALI in Autism, 23-3 (April 2019)
PermalinkA Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children / H. MAZAHERY in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
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