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Détail de l'auteur
Auteur Laurence COLLEAUX |
Documents disponibles écrits par cet auteur (3)
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Etat des connaissances sur les recherches génétiques dans les troubles envahissants du développement / Anne PHILIPPE
Titre : Etat des connaissances sur les recherches génétiques dans les troubles envahissants du développement Type de document : Texte imprimé et/ou numérique Auteurs : Anne PHILIPPE, Auteur ; Laurence COLLEAUX, Auteur ; Arnold MUNNICH, Auteur Année de publication : 2014 Importance : p.48-62 Note générale : Bibliogr. Langues : Français (fre) Index. décimale : PSY-B PSY-B - Autisme et Psychanalyse Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234 Etat des connaissances sur les recherches génétiques dans les troubles envahissants du développement [Texte imprimé et/ou numérique] / Anne PHILIPPE, Auteur ; Laurence COLLEAUX, Auteur ; Arnold MUNNICH, Auteur . - 2014 . - p.48-62.
Bibliogr.
Langues : Français (fre)
Index. décimale : PSY-B PSY-B - Autisme et Psychanalyse Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Génétique de la déficience intellectuelle / Laurence COLLEAUX
Titre : Génétique de la déficience intellectuelle Type de document : Texte imprimé et/ou numérique Auteurs : Laurence COLLEAUX, Auteur Année de publication : 2013 Importance : p.49-60 Langues : Français (fre) Index. décimale : TRO-C TRO-C - Déficience Intellectuelle Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=222 Génétique de la déficience intellectuelle [Texte imprimé et/ou numérique] / Laurence COLLEAUX, Auteur . - 2013 . - p.49-60.
Langues : Français (fre)
Index. décimale : TRO-C TRO-C - Déficience Intellectuelle Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=222 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits / Julien FREGEAC in Molecular Autism, 11 (2020)
[article]
Titre : Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits Type de document : Texte imprimé et/ou numérique Auteurs : Julien FREGEAC, Auteur ; Stéphanie MORICEAU, Auteur ; Antoine POLI, Auteur ; Lam Son NGUYEN, Auteur ; Franck OURY, Auteur ; Laurence COLLEAUX, Auteur Article en page(s) : 22 p. Langues : Anglais (eng) Mots-clés : Hippocampus-dependent cognitive functions MicroRNA Neural stem cells differentiation Neurodevelopment Neurodevelopmental disorders miR-146a Index. décimale : PER Périodiques Résumé : BACKGROUND: Formation and maintenance of appropriate neural networks require tight regulation of neural stem cell proliferation, differentiation, and neurogenesis. microRNAs (miRNAs) play an important role in brain development and plasticity, and dysregulated miRNA profiles have been linked to neurodevelopmental disorders including autism, schizophrenia, or intellectual disability. Yet, the functional role of miRNAs in neural development and postnatal brain functions remains unclear. METHODS: Using a combination of cell biology techniques as well as behavioral studies and brain imaging, we characterize mouse models with either constitutive inactivation or selectively hippocampal knockdown of the neurodevelopmental disease-associated gene Mir146a, the most commonly deregulated miRNA in developmental brain disorders (DBD). RESULTS: We first show that during development, loss of miR-146a impairs the differentiation of radial glial cells, neurogenesis process, and neurite extension. In the mouse adult brain, loss of miR-146a correlates with an increased hippocampal asymmetry coupled with defects in spatial learning and memory performances. Moreover, selective hippocampal downregulation of miR-146a in adult mice causes severe hippocampal-dependent memory impairments indicating for the first time a role for this miRNA in postnatal brain functions. CONCLUSION: Our results show that miR-146a expression is critical for correct differentiation of neural stem cell during brain development and provide for the first time a strong argument for a postnatal role of miR-146a in regulating hippocampal-dependent memory. Furthermore, the demonstration that the Mir146a(-/-) mouse recapitulates several aspects reported in DBD patients, including impaired neurogenesis, abnormal brain anatomy, and working and spatial memories deficits, provides convincing evidence that the dysregulation of miR146a contributes to the pathogenesis of DBDs. En ligne : http://dx.doi.org/10.1186/s13229-020-00328-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 22 p.[article] Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits [Texte imprimé et/ou numérique] / Julien FREGEAC, Auteur ; Stéphanie MORICEAU, Auteur ; Antoine POLI, Auteur ; Lam Son NGUYEN, Auteur ; Franck OURY, Auteur ; Laurence COLLEAUX, Auteur . - 22 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 22 p.
Mots-clés : Hippocampus-dependent cognitive functions MicroRNA Neural stem cells differentiation Neurodevelopment Neurodevelopmental disorders miR-146a Index. décimale : PER Périodiques Résumé : BACKGROUND: Formation and maintenance of appropriate neural networks require tight regulation of neural stem cell proliferation, differentiation, and neurogenesis. microRNAs (miRNAs) play an important role in brain development and plasticity, and dysregulated miRNA profiles have been linked to neurodevelopmental disorders including autism, schizophrenia, or intellectual disability. Yet, the functional role of miRNAs in neural development and postnatal brain functions remains unclear. METHODS: Using a combination of cell biology techniques as well as behavioral studies and brain imaging, we characterize mouse models with either constitutive inactivation or selectively hippocampal knockdown of the neurodevelopmental disease-associated gene Mir146a, the most commonly deregulated miRNA in developmental brain disorders (DBD). RESULTS: We first show that during development, loss of miR-146a impairs the differentiation of radial glial cells, neurogenesis process, and neurite extension. In the mouse adult brain, loss of miR-146a correlates with an increased hippocampal asymmetry coupled with defects in spatial learning and memory performances. Moreover, selective hippocampal downregulation of miR-146a in adult mice causes severe hippocampal-dependent memory impairments indicating for the first time a role for this miRNA in postnatal brain functions. CONCLUSION: Our results show that miR-146a expression is critical for correct differentiation of neural stem cell during brain development and provide for the first time a strong argument for a postnatal role of miR-146a in regulating hippocampal-dependent memory. Furthermore, the demonstration that the Mir146a(-/-) mouse recapitulates several aspects reported in DBD patients, including impaired neurogenesis, abnormal brain anatomy, and working and spatial memories deficits, provides convincing evidence that the dysregulation of miR146a contributes to the pathogenesis of DBDs. En ligne : http://dx.doi.org/10.1186/s13229-020-00328-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427