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Auteur Lucy RIGLIN |
Documents disponibles écrits par cet auteur (8)
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Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood / Amy SHAKESHAFT in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)
[article]
Titre : Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Amy SHAKESHAFT, Auteur ; Jon HERON, Auteur ; Rachel BLAKEY, Auteur ; Lucy RIGLIN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.1596-1607 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co-occur. Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co-develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent-reported ADHD and autistic traits between 4 and 25?years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three classes of trajectories were identified; a typically developing majority with low-stable ADHD-autistic traits (87%), a male-predominant subgroup with child/adolescent-declining traits (6%) and a subgroup with late-emerging traits (6%). ADHD-autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late-emerging classes compared to the low-stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood/adolescent-declining class compared to other classes, but were more prevalent in young adulthood in the late-emerging class. Neurodevelopmental/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low-stable group, and the late-emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS. Conclusions Distinct patterns of ADHD-autism co-development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS. En ligne : https://doi.org/10.1111/jcpp.13851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512
in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1596-1607[article] Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood [Texte imprimé et/ou numérique] / Amy SHAKESHAFT, Auteur ; Jon HERON, Auteur ; Rachel BLAKEY, Auteur ; Lucy RIGLIN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur . - p.1596-1607.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1596-1607
Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co-occur. Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co-develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent-reported ADHD and autistic traits between 4 and 25?years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three classes of trajectories were identified; a typically developing majority with low-stable ADHD-autistic traits (87%), a male-predominant subgroup with child/adolescent-declining traits (6%) and a subgroup with late-emerging traits (6%). ADHD-autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late-emerging classes compared to the low-stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood/adolescent-declining class compared to other classes, but were more prevalent in young adulthood in the late-emerging class. Neurodevelopmental/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low-stable group, and the late-emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS. Conclusions Distinct patterns of ADHD-autism co-development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS. En ligne : https://doi.org/10.1111/jcpp.13851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls / Lucy RIGLIN in Development and Psychopathology, 28-1 (February 2016)
[article]
Titre : Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls Type de document : Texte imprimé et/ou numérique Auteurs : Lucy RIGLIN, Auteur ; Stephan COLLISHAW, Auteur ; Katherine H. SHELTON, Auteur ; I. C. MCMANUS, Auteur ; Terry NG-KNIGHT, Auteur ; Ruth SELLERS, Auteur ; Ajay K. THAPAR, Auteur ; Norah FREDERICKSON, Auteur ; Frances RICE, Auteur Article en page(s) : p.97-109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology. En ligne : http://dx.doi.org/10.1017/S0954579415000310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278
in Development and Psychopathology > 28-1 (February 2016) . - p.97-109[article] Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls [Texte imprimé et/ou numérique] / Lucy RIGLIN, Auteur ; Stephan COLLISHAW, Auteur ; Katherine H. SHELTON, Auteur ; I. C. MCMANUS, Auteur ; Terry NG-KNIGHT, Auteur ; Ruth SELLERS, Auteur ; Ajay K. THAPAR, Auteur ; Norah FREDERICKSON, Auteur ; Frances RICE, Auteur . - p.97-109.
Langues : Anglais (eng)
in Development and Psychopathology > 28-1 (February 2016) . - p.97-109
Index. décimale : PER Périodiques Résumé : Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology. En ligne : http://dx.doi.org/10.1017/S0954579415000310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? / Lucy RIGLIN in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)
[article]
Titre : Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? Type de document : Texte imprimé et/ou numérique Auteurs : Lucy RIGLIN, Auteur ; Beate LEPPERT, Auteur ; Kate LANGLEY, Auteur ; Ajay K. THAPAR, Auteur ; Michael C. O'DONOVAN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.449-457 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children Neurodevelopmental adult attention-deficit hyperactivity disorder autism spectrum disorder genetic Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are generally considered early-onset disorders so most research has therefore tended to focus on children. Differences between ADHD/ASD in adult life and childhood have been noted, but few population-based studies have examined them in adulthood. Furthermore, the interpretation of findings is hampered by changes in measure and from parent report to self-report. METHOD: We examined continuous/trait measures of parent- and self-rated ADHD and ASD in adulthood (age 25 years) in a UK prospective longitudinal sample ALPSAC (the Avon Longitudinal Study of Parents and Children), using many of the same measures that parents reported on in childhood (N = 6,064). Our aim was to investigate these traits in this population for mean-level sex differences, overlaps with other cognitive, learning and communication problems and their associations with polygenic risk scores (PRS) for neuropsychiatric disorders (ADHD, ASD, schizophrenia, depression and anxiety). RESULTS: ADHD and ASD traits in adulthood, as in childhood, showed associations with childhood cognitive, learning and communication problems and adult communication/language measures, although less so for self-ratings than parent-ratings. Males had higher ADHD and ASD trait levels, but this was not as marked as in childhood. In adulthood, ADHD (both parent- and self-rated) and ASD (parent-rated) symptoms showed associations with ADHD PRS; self-reported ADHD also showed association with depression PRS, whereas self-reported ASD did not show strong PRS associations. CONCLUSIONS: Our findings suggest that in young adults, ADHD and ASD symptoms have similar characteristics as they do in childhood. Associations with other cognitive, learning and communication problems, and ADHD PRS were somewhat less pronounced for self-reported adult ADHD and ASD symptoms, suggesting that even at age 25, parent reports, where available, could be clinically useful. En ligne : http://dx.doi.org/10.1111/jcpp.13297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.449-457[article] Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? [Texte imprimé et/ou numérique] / Lucy RIGLIN, Auteur ; Beate LEPPERT, Auteur ; Kate LANGLEY, Auteur ; Ajay K. THAPAR, Auteur ; Michael C. O'DONOVAN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur . - p.449-457.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.449-457
Mots-clés : Avon Longitudinal Study of Parents and Children Neurodevelopmental adult attention-deficit hyperactivity disorder autism spectrum disorder genetic Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are generally considered early-onset disorders so most research has therefore tended to focus on children. Differences between ADHD/ASD in adult life and childhood have been noted, but few population-based studies have examined them in adulthood. Furthermore, the interpretation of findings is hampered by changes in measure and from parent report to self-report. METHOD: We examined continuous/trait measures of parent- and self-rated ADHD and ASD in adulthood (age 25 years) in a UK prospective longitudinal sample ALPSAC (the Avon Longitudinal Study of Parents and Children), using many of the same measures that parents reported on in childhood (N = 6,064). Our aim was to investigate these traits in this population for mean-level sex differences, overlaps with other cognitive, learning and communication problems and their associations with polygenic risk scores (PRS) for neuropsychiatric disorders (ADHD, ASD, schizophrenia, depression and anxiety). RESULTS: ADHD and ASD traits in adulthood, as in childhood, showed associations with childhood cognitive, learning and communication problems and adult communication/language measures, although less so for self-ratings than parent-ratings. Males had higher ADHD and ASD trait levels, but this was not as marked as in childhood. In adulthood, ADHD (both parent- and self-rated) and ASD (parent-rated) symptoms showed associations with ADHD PRS; self-reported ADHD also showed association with depression PRS, whereas self-reported ASD did not show strong PRS associations. CONCLUSIONS: Our findings suggest that in young adults, ADHD and ASD symptoms have similar characteristics as they do in childhood. Associations with other cognitive, learning and communication problems, and ADHD PRS were somewhat less pronounced for self-reported adult ADHD and ASD symptoms, suggesting that even at age 25, parent reports, where available, could be clinically useful. En ligne : http://dx.doi.org/10.1111/jcpp.13297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment / Adhip RAWAL in Journal of Child Psychology and Psychiatry, 55-11 (November 2014)
[article]
Titre : A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment Type de document : Texte imprimé et/ou numérique Auteurs : Adhip RAWAL, Auteur ; Lucy RIGLIN, Auteur ; Terry NG-KNIGHT, Auteur ; Stephan COLLISHAW, Auteur ; Anita THAPAR, Auteur ; Frances RICE, Auteur Article en page(s) : p.1270-1278 Langues : Anglais (eng) Mots-clés : Depression anxiety adolescence reward decision-making Index. décimale : PER Périodiques Résumé : Background Adolescence is associated with developments in the reward system and increased rates of emotional disorders. Familial risk for depression may be associated with disruptions in the reward system. However, it is unclear how symptoms of depression and anxiety influence the development of reward-processing over adolescence and whether variation in the severity of parental depression is associated with hyposensitivity to reward in a high-risk sample. Methods We focused on risk-adjustment (adjusting decisions about reward according to the probability of obtaining reward) as this was hypothesized to improve over adolescence. In a one-year longitudinal sample (N = 197) of adolescent offspring of depressed parents, we examined how symptoms of depression and anxiety (generalized anxiety and social anxiety) influenced the development of risk-adjustment. We also examined how parental depression severity influenced adolescent risk-adjustment. Results Risk-adjustment improved over the course of the study indicating improved adjustment of reward-seeking to shifting contingencies. Depressive symptoms were associated with decreases in risk-adjustment over time while social anxiety symptoms were associated with increases in risk-adjustment over time. Specifically, depression was associated with reductions in reward-seeking at favourable reward probabilities only, whereas social anxiety (but not generalized anxiety) led to reductions in reward-seeking at low reward probabilities only. Parent depression severity was associated with lowered risk-adjustment in offspring and also influenced the longitudinal relationship between risk-adjustment and offspring depression. Conclusions Anxiety and depression distinctly alter the pattern of longitudinal change in reward-processing. Severity of parent depression was associated with alterations in adolescent offspring reward-processing in a high-risk sample. En ligne : http://dx.doi.org/10.1111/jcpp.12279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Journal of Child Psychology and Psychiatry > 55-11 (November 2014) . - p.1270-1278[article] A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment [Texte imprimé et/ou numérique] / Adhip RAWAL, Auteur ; Lucy RIGLIN, Auteur ; Terry NG-KNIGHT, Auteur ; Stephan COLLISHAW, Auteur ; Anita THAPAR, Auteur ; Frances RICE, Auteur . - p.1270-1278.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-11 (November 2014) . - p.1270-1278
Mots-clés : Depression anxiety adolescence reward decision-making Index. décimale : PER Périodiques Résumé : Background Adolescence is associated with developments in the reward system and increased rates of emotional disorders. Familial risk for depression may be associated with disruptions in the reward system. However, it is unclear how symptoms of depression and anxiety influence the development of reward-processing over adolescence and whether variation in the severity of parental depression is associated with hyposensitivity to reward in a high-risk sample. Methods We focused on risk-adjustment (adjusting decisions about reward according to the probability of obtaining reward) as this was hypothesized to improve over adolescence. In a one-year longitudinal sample (N = 197) of adolescent offspring of depressed parents, we examined how symptoms of depression and anxiety (generalized anxiety and social anxiety) influenced the development of risk-adjustment. We also examined how parental depression severity influenced adolescent risk-adjustment. Results Risk-adjustment improved over the course of the study indicating improved adjustment of reward-seeking to shifting contingencies. Depressive symptoms were associated with decreases in risk-adjustment over time while social anxiety symptoms were associated with increases in risk-adjustment over time. Specifically, depression was associated with reductions in reward-seeking at favourable reward probabilities only, whereas social anxiety (but not generalized anxiety) led to reductions in reward-seeking at low reward probabilities only. Parent depression severity was associated with lowered risk-adjustment in offspring and also influenced the longitudinal relationship between risk-adjustment and offspring depression. Conclusions Anxiety and depression distinctly alter the pattern of longitudinal change in reward-processing. Severity of parent depression was associated with alterations in adolescent offspring reward-processing in a high-risk sample. En ligne : http://dx.doi.org/10.1111/jcpp.12279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Practitioner Review: Attention-deficit hyperactivity disorder and autism spectrum disorder - the importance of depression / Anita THAPAR in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)
[article]
Titre : Practitioner Review: Attention-deficit hyperactivity disorder and autism spectrum disorder - the importance of depression Type de document : Texte imprimé et/ou numérique Auteurs : Anita THAPAR, Auteur ; Lucy A. LIVINGSTON, Auteur ; Olga EYRE, Auteur ; Lucy RIGLIN, Auteur Article en page(s) : p.4-15 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Young people with neurodevelopmental disorders, such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), show high rates of mental health problems, of which depression is one of the most common. Given that depression in ASD and ADHD is linked with a range of poor outcomes, knowledge of how clinicians should assess, identify and treat depression in the context of these neurodevelopmental disorders is much needed. Here, we give an overview of the latest research on depression in young people with ADHD and ASD, including possible mechanisms underlying the link between ADHD/ASD and depression, as well as the presentation, assessment and treatment of depression in these neurodevelopmental disorders. We discuss the implications for clinicians and make recommendations for critical future research in this area. En ligne : https://doi.org/10.1111/jcpp.13678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.4-15[article] Practitioner Review: Attention-deficit hyperactivity disorder and autism spectrum disorder - the importance of depression [Texte imprimé et/ou numérique] / Anita THAPAR, Auteur ; Lucy A. LIVINGSTON, Auteur ; Olga EYRE, Auteur ; Lucy RIGLIN, Auteur . - p.4-15.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.4-15
Index. décimale : PER Périodiques Résumé : Young people with neurodevelopmental disorders, such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), show high rates of mental health problems, of which depression is one of the most common. Given that depression in ASD and ADHD is linked with a range of poor outcomes, knowledge of how clinicians should assess, identify and treat depression in the context of these neurodevelopmental disorders is much needed. Here, we give an overview of the latest research on depression in young people with ADHD and ASD, including possible mechanisms underlying the link between ADHD/ASD and depression, as well as the presentation, assessment and treatment of depression in these neurodevelopmental disorders. We discuss the implications for clinicians and make recommendations for critical future research in this area. En ligne : https://doi.org/10.1111/jcpp.13678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Profiling depression in childhood and adolescence: the role of conduct problems / Lucy RIGLIN in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)
PermalinkStratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry / Joanna MARTIN ; Amy SHAKESHAFT ; Lucy RIGLIN ; Frances RICE ; Cathryn M. LEWIS ; Michael C. O'DONOVAN ; Anita THAPAR in Journal of Child Psychology and Psychiatry, 65-1 (January 2024)
PermalinkUsing genetic designs to identify likely causal environmental contributions to psychopathology / Ruth SELLERS in Development and Psychopathology, 34-5 (December 2022)
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