Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior / Zoë H. BRETT in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.7-18 Titre : Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior Type de document : Texte imprimé et/ou numérique Auteurs : Zoë H. BRETT, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Anna T. SMYKE, Auteur ; Mary Margaret GLEASON, Auteur ; Charles A. NELSON, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Stacy S. DRURY, Auteur Article en page(s) : p.7-18 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined caregiver report of externalizing behavior from 12 to 54 months of age in 102 children randomized to care as usual in institutions or to newly created high-quality foster care. At baseline no differences by group or genotype in externalizing were found. However, changes in externalizing from baseline to 42 months of age were moderated by the serotonin transporter linked polymorphic region genotype and intervention group, where the slope for short–short (S/S) individuals differed as a function of intervention group. The slope for individuals carrying the long allele did not significantly differ between groups. At 54 months of age, S/S children in the foster care group had the lowest levels of externalizing behavior, while children with the S/S genotype in the care as usual group demonstrated the highest rates of externalizing behavior. No intervention group differences were found in externalizing behavior among children who carried the long allele. These findings, within a randomized controlled trial of foster care compared to continued care as usual, indicate that the serotonin transporter linked polymorphic region genotype moderates the relation between early caregiving environments to predict externalizing behavior in children exposed to early institutional care in a manner most consistent with differential susceptibility. En ligne : http://dx.doi.org/10.1017/S0954579414001266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior [Texte imprimé et/ou numérique] / Zoë H. BRETT, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Anna T. SMYKE, Auteur ; Mary Margaret GLEASON, Auteur ; Charles A. NELSON, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Stacy S. DRURY, Auteur . - p.7-18. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.7-18 Index. décimale : PER Périodiques Résumé : We examined caregiver report of externalizing behavior from 12 to 54 months of age in 102 children randomized to care as usual in institutions or to newly created high-quality foster care. At baseline no differences by group or genotype in externalizing were found. However, changes in externalizing from baseline to 42 months of age were moderated by the serotonin transporter linked polymorphic region genotype and intervention group, where the slope for short–short (S/S) individuals differed as a function of intervention group. The slope for individuals carrying the long allele did not significantly differ between groups. At 54 months of age, S/S children in the foster care group had the lowest levels of externalizing behavior, while children with the S/S genotype in the care as usual group demonstrated the highest rates of externalizing behavior. No intervention group differences were found in externalizing behavior among children who carried the long allele. These findings, within a randomized controlled trial of foster care compared to continued care as usual, indicate that the serotonin transporter linked polymorphic region genotype moderates the relation between early caregiving environments to predict externalizing behavior in children exposed to early institutional care in a manner most consistent with differential susceptibility. En ligne : http://dx.doi.org/10.1017/S0954579414001266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development / Zoë H. BRETT in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.347-367 Titre : Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development Type de document : Texte imprimé et/ou numérique Auteurs : Zoë H. BRETT, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alison S. FLEMING, Auteur ; Gary W. KRAEMER, Auteur ; Stacy S. DRURY, Auteur Article en page(s) : p.347-367 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Building upon the transactional model of brain development, we explore the impact of early maternal deprivation on neural development and plasticity in three neural systems: hyperactivity/impulsivity, executive function, and hypothalamic–pituitary–adrenal axis functioning across rodent, nonhuman primate, and human studies. Recognizing the complexity of early maternal–infant interactions, we limit our cross-species comparisons to data from rodent models of artificial rearing, nonhuman primate studies of peer rearing, and the relations between these two experimental approaches and human studies of children exposed to the early severe psychosocial deprivation associated with institutional care. In addition to discussing the strengths and limitations of these paradigms, we present the current state of research on the neurobiological impact of early maternal deprivation and the evidence of sensitive periods, noting methodological challenges. Integrating data across preclinical animal models and human studies, we speculate about the underlying biological mechanisms; the differential impact of deprivation due to temporal factors including onset, offset, and duration of the exposure; and the possibility and consequences of reopening of sensitive periods during adolescence. En ligne : http://dx.doi.org/10.1017/S0954579415000036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development [Texte imprimé et/ou numérique] / Zoë H. BRETT, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alison S. FLEMING, Auteur ; Gary W. KRAEMER, Auteur ; Stacy S. DRURY, Auteur . - p.347-367. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.347-367 Index. décimale : PER Périodiques Résumé : Building upon the transactional model of brain development, we explore the impact of early maternal deprivation on neural development and plasticity in three neural systems: hyperactivity/impulsivity, executive function, and hypothalamic–pituitary–adrenal axis functioning across rodent, nonhuman primate, and human studies. Recognizing the complexity of early maternal–infant interactions, we limit our cross-species comparisons to data from rodent models of artificial rearing, nonhuman primate studies of peer rearing, and the relations between these two experimental approaches and human studies of children exposed to the early severe psychosocial deprivation associated with institutional care. In addition to discussing the strengths and limitations of these paradigms, we present the current state of research on the neurobiological impact of early maternal deprivation and the evidence of sensitive periods, noting methodological challenges. Integrating data across preclinical animal models and human studies, we speculate about the underlying biological mechanisms; the differential impact of deprivation due to temporal factors including onset, offset, and duration of the exposure; and the possibility and consequences of reopening of sensitive periods during adolescence. En ligne : http://dx.doi.org/10.1017/S0954579415000036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

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