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Auteur Cynthia M. BULIK |
Documents disponibles écrits par cet auteur (4)
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Anorexia nervosa and autism: a prospective twin cohort study / Lisa DINKLER in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)
[article]
Titre : Anorexia nervosa and autism: a prospective twin cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Lisa DINKLER, Auteur ; Mark J. TAYLOR, Auteur ; Maria RASTAM, Auteur ; Nouchine HADJIKHANI, Auteur ; Cynthia M. BULIK, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur Article en page(s) : p.316-326 Langues : Anglais (eng) Mots-clés : Eating disorder anorexia nervosa autism spectrum disorders longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. METHODS: In a population-based sample of 5,987 individuals (52.4% female) from the Child and Adolescent Twin Study in Sweden, parents reported autistic traits at ages 9 and 18. AN and ASD diagnoses were retrieved from the Swedish National Patient Register. In addition, AN diagnoses were ascertained by parent-reported treatment for AN. We compared whether individuals with and without AN differed in autistic traits before the first diagnosis of AN (age 9) and after the first diagnosis of AN (age 18). RESULTS: We did not find evidence for elevated autistic traits in 9-year-old children later diagnosed with AN. At age 18, however, there was a marked elevation in restricted/repetitive behavior and interests, but only in the subgroup of individuals with acute AN. A less pronounced elevation was observed for social communication problems. CONCLUSIONS: Coping strategies in individuals with ASD and the somewhat different female ASD phenotype may explain why we did not find elevated autistic traits in children who later developed AN. Alternatively, it is possible that elevated autistic traits were not present prior to the onset of AN, thus questioning the previously reported elevated prevalence of ASD in AN. Future studies should use tailored measurements in order to investigate whether autistic traits in individuals with AN are best conceptualized as an epiphenomenon of the acute AN phase or whether these symptoms indeed represent ASD as a clinically verifiable neurodevelopmental disorder. En ligne : http://dx.doi.org/10.1111/jcpp.13265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443
in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.316-326[article] Anorexia nervosa and autism: a prospective twin cohort study [Texte imprimé et/ou numérique] / Lisa DINKLER, Auteur ; Mark J. TAYLOR, Auteur ; Maria RASTAM, Auteur ; Nouchine HADJIKHANI, Auteur ; Cynthia M. BULIK, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur . - p.316-326.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.316-326
Mots-clés : Eating disorder anorexia nervosa autism spectrum disorders longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. METHODS: In a population-based sample of 5,987 individuals (52.4% female) from the Child and Adolescent Twin Study in Sweden, parents reported autistic traits at ages 9 and 18. AN and ASD diagnoses were retrieved from the Swedish National Patient Register. In addition, AN diagnoses were ascertained by parent-reported treatment for AN. We compared whether individuals with and without AN differed in autistic traits before the first diagnosis of AN (age 9) and after the first diagnosis of AN (age 18). RESULTS: We did not find evidence for elevated autistic traits in 9-year-old children later diagnosed with AN. At age 18, however, there was a marked elevation in restricted/repetitive behavior and interests, but only in the subgroup of individuals with acute AN. A less pronounced elevation was observed for social communication problems. CONCLUSIONS: Coping strategies in individuals with ASD and the somewhat different female ASD phenotype may explain why we did not find elevated autistic traits in children who later developed AN. Alternatively, it is possible that elevated autistic traits were not present prior to the onset of AN, thus questioning the previously reported elevated prevalence of ASD in AN. Future studies should use tailored measurements in order to investigate whether autistic traits in individuals with AN are best conceptualized as an epiphenomenon of the acute AN phase or whether these symptoms indeed represent ASD as a clinically verifiable neurodevelopmental disorder. En ligne : http://dx.doi.org/10.1111/jcpp.13265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 Anxiety disorder symptoms at age 10 predict eating disorder symptoms and diagnoses in adolescence / K. SCHAUMBERG in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)
[article]
Titre : Anxiety disorder symptoms at age 10 predict eating disorder symptoms and diagnoses in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : K. SCHAUMBERG, Auteur ; S. ZERWAS, Auteur ; E. GOODMAN, Auteur ; Z. YILMAZ, Auteur ; Cynthia M. BULIK, Auteur ; N. MICALI, Auteur Article en page(s) : p.686-696 Langues : Anglais (eng) Mots-clés : Anxiety Avon longitudinal study of parents and children eating disorder obsessive-compulsive disorder structural equation modeling Index. décimale : PER Périodiques Résumé : BACKGROUND: Cross-sectional associations between anxiety disorders and eating disorders (EDs) have been well documented; however, limited research has examined whether symptoms of anxiety disorders are prospectively associated with EDs. Identifying these longitudinal associations can aid in discerning relationships among eating and anxiety disorders and point toward a mechanistic understanding of developmental psychopathology. This study investigated the prospective associations between parent-reported anxiety in mid-childhood (age 10) and child-reported ED behaviors and disorders in adolescence (at ages 14 and 16 years) in a population-based sample. METHODS: Participants were individuals enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based, prospective study of women and their children; 7,767 children whose parents provided data at age 10 were included in current analyses. An exploratory factor analysis identified latent anxiety factors at age 10, followed by a path analysis that evaluated associations between these factors and eating disorder symptoms and cognitions at age 14. RESULTS: Parent-reported anxiety symptoms at age 10 yielded 5 factors: obsessive-compulsive disorder (OCD) symptoms related to symmetry and checking (Factor 1); OCD symptoms associated with aversion to dirt and germs (Factor 2); physical anxiety symptoms (Factor 3); worries (Factor 4); and social phobia symptoms (Factor 5). Factors 3 and 4 showed the most consistent, positive associations with a range of ED symptoms at age 14. Factor 3 predicted diagnosis of bulimia nervosa by age 16 (OR = 1.11, p = .007), whereas Factor 4 predicted diagnoses of anorexia nervosa (OR = 1.10, p = .01) and disordered eating by age 16 (OR = 1.08, p = .001). CONCLUSIONS: Results indicate that symptoms of generalized anxiety in middle childhood may predict adolescent-onset ED symptoms and ED diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.12984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397
in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.686-696[article] Anxiety disorder symptoms at age 10 predict eating disorder symptoms and diagnoses in adolescence [Texte imprimé et/ou numérique] / K. SCHAUMBERG, Auteur ; S. ZERWAS, Auteur ; E. GOODMAN, Auteur ; Z. YILMAZ, Auteur ; Cynthia M. BULIK, Auteur ; N. MICALI, Auteur . - p.686-696.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.686-696
Mots-clés : Anxiety Avon longitudinal study of parents and children eating disorder obsessive-compulsive disorder structural equation modeling Index. décimale : PER Périodiques Résumé : BACKGROUND: Cross-sectional associations between anxiety disorders and eating disorders (EDs) have been well documented; however, limited research has examined whether symptoms of anxiety disorders are prospectively associated with EDs. Identifying these longitudinal associations can aid in discerning relationships among eating and anxiety disorders and point toward a mechanistic understanding of developmental psychopathology. This study investigated the prospective associations between parent-reported anxiety in mid-childhood (age 10) and child-reported ED behaviors and disorders in adolescence (at ages 14 and 16 years) in a population-based sample. METHODS: Participants were individuals enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based, prospective study of women and their children; 7,767 children whose parents provided data at age 10 were included in current analyses. An exploratory factor analysis identified latent anxiety factors at age 10, followed by a path analysis that evaluated associations between these factors and eating disorder symptoms and cognitions at age 14. RESULTS: Parent-reported anxiety symptoms at age 10 yielded 5 factors: obsessive-compulsive disorder (OCD) symptoms related to symmetry and checking (Factor 1); OCD symptoms associated with aversion to dirt and germs (Factor 2); physical anxiety symptoms (Factor 3); worries (Factor 4); and social phobia symptoms (Factor 5). Factors 3 and 4 showed the most consistent, positive associations with a range of ED symptoms at age 14. Factor 3 predicted diagnosis of bulimia nervosa by age 16 (OR = 1.11, p = .007), whereas Factor 4 predicted diagnoses of anorexia nervosa (OR = 1.10, p = .01) and disordered eating by age 16 (OR = 1.08, p = .001). CONCLUSIONS: Results indicate that symptoms of generalized anxiety in middle childhood may predict adolescent-onset ED symptoms and ED diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.12984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 Bidirectional relationship between eating disorders and autoimmune diseases / A. HEDMAN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)
[article]
Titre : Bidirectional relationship between eating disorders and autoimmune diseases Type de document : Texte imprimé et/ou numérique Auteurs : A. HEDMAN, Auteur ; L. BREITHAUPT, Auteur ; C. HUBEL, Auteur ; L. M. THORNTON, Auteur ; A. TILLANDER, Auteur ; C. NORRING, Auteur ; A. BIRGEGARD, Auteur ; H. LARSSON, Auteur ; J. F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur Article en page(s) : p.803-812 Langues : Anglais (eng) Mots-clés : anorexia nervosa autoimmunity bulimia nervosa cox regression hazard immune system risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812[article] Bidirectional relationship between eating disorders and autoimmune diseases [Texte imprimé et/ou numérique] / A. HEDMAN, Auteur ; L. BREITHAUPT, Auteur ; C. HUBEL, Auteur ; L. M. THORNTON, Auteur ; A. TILLANDER, Auteur ; C. NORRING, Auteur ; A. BIRGEGARD, Auteur ; H. LARSSON, Auteur ; J. F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur . - p.803-812.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812
Mots-clés : anorexia nervosa autoimmunity bulimia nervosa cox regression hazard immune system risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Patterns of maladaptive exercise behavior from ages 14-24 in a longitudinal cohort / Katherine SCHAUMBERG in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)
[article]
Titre : Patterns of maladaptive exercise behavior from ages 14-24 in a longitudinal cohort Type de document : Texte imprimé et/ou numérique Auteurs : Katherine SCHAUMBERG, Auteur ; Cynthia M. BULIK, Auteur ; Nadia MICALI, Auteur Article en page(s) : p.1555-1568 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Exercise for weight loss and maladaptive exercise (exercise that results in negative consequences or interference with daily life) are common behaviors among youth and are associated with increased risk of disordered eating symptoms. The current study clarifies processes that influence exercise-related risk in adolescence and young adulthood, including the frequency with which young people transition between engaging in exercise for weight loss and experiencing negative consequences of this behavior. Method Participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) reported on eating disorder cognitions at age 14, and exercise behavior at ages 14, 16, 18, and 24?years old. Analyses examined rates of transition between the categories of 'No Exercise for Weight Loss', 'Exercise for Weight Loss', and 'Maladaptive Exercise' over time, identified overall trends in endorsement of exercise for weight loss and maladaptive exercise, and clarified predictors of these behaviors. Results Endorsement of exercise for weight loss and maladaptive exercise increased over time in both males and females. Those in the 'Exercise for Weight Loss' category were more likely than those in the 'No Exercise for Weight Loss Category' to transition to 'Maladaptive Exercise' over time. Body mass index (Age 13) and fear of weight gain (Age 14) were consistent predictors of maladaptive exercise across sex. Conclusions Results support re-framing motivations for exercise in youth away from weight loss at a population level and targeting reductions in fear of weight gain for high-risk individuals. En ligne : https://doi.org/10.1111/jcpp.13844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512
in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1555-1568[article] Patterns of maladaptive exercise behavior from ages 14-24 in a longitudinal cohort [Texte imprimé et/ou numérique] / Katherine SCHAUMBERG, Auteur ; Cynthia M. BULIK, Auteur ; Nadia MICALI, Auteur . - p.1555-1568.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1555-1568
Index. décimale : PER Périodiques Résumé : Background Exercise for weight loss and maladaptive exercise (exercise that results in negative consequences or interference with daily life) are common behaviors among youth and are associated with increased risk of disordered eating symptoms. The current study clarifies processes that influence exercise-related risk in adolescence and young adulthood, including the frequency with which young people transition between engaging in exercise for weight loss and experiencing negative consequences of this behavior. Method Participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) reported on eating disorder cognitions at age 14, and exercise behavior at ages 14, 16, 18, and 24?years old. Analyses examined rates of transition between the categories of 'No Exercise for Weight Loss', 'Exercise for Weight Loss', and 'Maladaptive Exercise' over time, identified overall trends in endorsement of exercise for weight loss and maladaptive exercise, and clarified predictors of these behaviors. Results Endorsement of exercise for weight loss and maladaptive exercise increased over time in both males and females. Those in the 'Exercise for Weight Loss' category were more likely than those in the 'No Exercise for Weight Loss Category' to transition to 'Maladaptive Exercise' over time. Body mass index (Age 13) and fear of weight gain (Age 14) were consistent predictors of maladaptive exercise across sex. Conclusions Results support re-framing motivations for exercise in youth away from weight loss at a population level and targeting reductions in fear of weight gain for high-risk individuals. En ligne : https://doi.org/10.1111/jcpp.13844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512