Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood / Amy SHAKESHAFT in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1596-1607 Titre : Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Amy SHAKESHAFT, Auteur ; Jon HERON, Auteur ; Rachel BLAKEY, Auteur ; Lucy RIGLIN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.1596-1607 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co-occur. Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co-develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent-reported ADHD and autistic traits between 4 and 25?years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three classes of trajectories were identified; a typically developing majority with low-stable ADHD-autistic traits (87%), a male-predominant subgroup with child/adolescent-declining traits (6%) and a subgroup with late-emerging traits (6%). ADHD-autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late-emerging classes compared to the low-stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood/adolescent-declining class compared to other classes, but were more prevalent in young adulthood in the late-emerging class. Neurodevelopmental/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low-stable group, and the late-emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS. Conclusions Distinct patterns of ADHD-autism co-development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS. En ligne : https://doi.org/10.1111/jcpp.13851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood [Texte imprimé et/ou numérique] / Amy SHAKESHAFT, Auteur ; Jon HERON, Auteur ; Rachel BLAKEY, Auteur ; Lucy RIGLIN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur . - p.1596-1607. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1596-1607 Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co-occur. Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co-develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent-reported ADHD and autistic traits between 4 and 25?years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three classes of trajectories were identified; a typically developing majority with low-stable ADHD-autistic traits (87%), a male-predominant subgroup with child/adolescent-declining traits (6%) and a subgroup with late-emerging traits (6%). ADHD-autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late-emerging classes compared to the low-stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood/adolescent-declining class compared to other classes, but were more prevalent in young adulthood in the late-emerging class. Neurodevelopmental/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low-stable group, and the late-emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS. Conclusions Distinct patterns of ADHD-autism co-development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS. En ligne : https://doi.org/10.1111/jcpp.13851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? / Lucy RIGLIN in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.449-457 Titre : Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? Type de document : Texte imprimé et/ou numérique Auteurs : Lucy RIGLIN, Auteur ; Beate LEPPERT, Auteur ; Kate LANGLEY, Auteur ; Ajay K. THAPAR, Auteur ; Michael C. O'DONOVAN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.449-457 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  Neurodevelopmental  adult  attention-deficit hyperactivity disorder  autism spectrum disorder  genetic Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are generally considered early-onset disorders so most research has therefore tended to focus on children. Differences between ADHD/ASD in adult life and childhood have been noted, but few population-based studies have examined them in adulthood. Furthermore, the interpretation of findings is hampered by changes in measure and from parent report to self-report. METHOD: We examined continuous/trait measures of parent- and self-rated ADHD and ASD in adulthood (age 25 years) in a UK prospective longitudinal sample ALPSAC (the Avon Longitudinal Study of Parents and Children), using many of the same measures that parents reported on in childhood (N = 6,064). Our aim was to investigate these traits in this population for mean-level sex differences, overlaps with other cognitive, learning and communication problems and their associations with polygenic risk scores (PRS) for neuropsychiatric disorders (ADHD, ASD, schizophrenia, depression and anxiety). RESULTS: ADHD and ASD traits in adulthood, as in childhood, showed associations with childhood cognitive, learning and communication problems and adult communication/language measures, although less so for self-ratings than parent-ratings. Males had higher ADHD and ASD trait levels, but this was not as marked as in childhood. In adulthood, ADHD (both parent- and self-rated) and ASD (parent-rated) symptoms showed associations with ADHD PRS; self-reported ADHD also showed association with depression PRS, whereas self-reported ASD did not show strong PRS associations. CONCLUSIONS: Our findings suggest that in young adults, ADHD and ASD symptoms have similar characteristics as they do in childhood. Associations with other cognitive, learning and communication problems, and ADHD PRS were somewhat less pronounced for self-reported adult ADHD and ASD symptoms, suggesting that even at age 25, parent reports, where available, could be clinically useful. En ligne : http://dx.doi.org/10.1111/jcpp.13297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? [Texte imprimé et/ou numérique] / Lucy RIGLIN, Auteur ; Beate LEPPERT, Auteur ; Kate LANGLEY, Auteur ; Ajay K. THAPAR, Auteur ; Michael C. O'DONOVAN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur . - p.449-457. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.449-457 Mots-clés : Avon Longitudinal Study of Parents and Children  Neurodevelopmental  adult  attention-deficit hyperactivity disorder  autism spectrum disorder  genetic Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are generally considered early-onset disorders so most research has therefore tended to focus on children. Differences between ADHD/ASD in adult life and childhood have been noted, but few population-based studies have examined them in adulthood. Furthermore, the interpretation of findings is hampered by changes in measure and from parent report to self-report. METHOD: We examined continuous/trait measures of parent- and self-rated ADHD and ASD in adulthood (age 25 years) in a UK prospective longitudinal sample ALPSAC (the Avon Longitudinal Study of Parents and Children), using many of the same measures that parents reported on in childhood (N = 6,064). Our aim was to investigate these traits in this population for mean-level sex differences, overlaps with other cognitive, learning and communication problems and their associations with polygenic risk scores (PRS) for neuropsychiatric disorders (ADHD, ASD, schizophrenia, depression and anxiety). RESULTS: ADHD and ASD traits in adulthood, as in childhood, showed associations with childhood cognitive, learning and communication problems and adult communication/language measures, although less so for self-ratings than parent-ratings. Males had higher ADHD and ASD trait levels, but this was not as marked as in childhood. In adulthood, ADHD (both parent- and self-rated) and ASD (parent-rated) symptoms showed associations with ADHD PRS; self-reported ADHD also showed association with depression PRS, whereas self-reported ASD did not show strong PRS associations. CONCLUSIONS: Our findings suggest that in young adults, ADHD and ASD symptoms have similar characteristics as they do in childhood. Associations with other cognitive, learning and communication problems, and ADHD PRS were somewhat less pronounced for self-reported adult ADHD and ASD symptoms, suggesting that even at age 25, parent reports, where available, could be clinically useful. En ligne : http://dx.doi.org/10.1111/jcpp.13297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Relative age in the school year and risk of mental health problems in childhood, adolescence and young adulthood / Thomas BROUGHTON in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.185-196 Titre : Relative age in the school year and risk of mental health problems in childhood, adolescence and young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Thomas BROUGHTON, Auteur ; Kate LANGLEY, Auteur ; Kate TILLING, Auteur ; Stephan COLLISHAW, Auteur Article en page(s) : p.185-196 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose Relative age within the school year ( ˜relative age’) is associated with increased rates of symptoms and diagnoses of mental health disorders, including ADHD. We aimed to investigate how relative age influences mental health and behaviour before, during and after school (age range: 4-25 years). Method We used a regression discontinuity design to examine the effect of relative age on risk of mental health problems using data from a large UK population-based cohort (Avon Longitudinal Study of Parents and Children (ALSPAC); N=14,643). We compared risk of mental health problems between ages 4 and 25 years using the parent-rated Strengths and Difficulties Questionnaire (SDQ), and depression using self-rated and parent-rated Short Mood and Feelings Questionnaire (SMFQ) by relative age. Results The youngest children in the school year have greater parent-rated risk of mental health problems, measured using parent-rated SDQ total difficulties scores. We found no evidence of differences before school entry [estimated standardised mean difference (SMD) between those born on 31 August and 1 September: .02 (â’.05, .08)]. We found that estimates of effect size for a 1-year difference in relative age were greatest at 11 years [SMD: .22 (.15, .29)], but attenuated to the null at 25 years [SMD: â’.02 (â’.11, .07)]. We did not find consistent evidence of differences in self-rated and parent-rated depression by relative age. Conclusions Younger relative age is associated with poorer parent-rated general mental health, but not symptoms of depression. En ligne : https://doi.org/10.1111/jcpp.13684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Relative age in the school year and risk of mental health problems in childhood, adolescence and young adulthood [Texte imprimé et/ou numérique] / Thomas BROUGHTON, Auteur ; Kate LANGLEY, Auteur ; Kate TILLING, Auteur ; Stephan COLLISHAW, Auteur . - p.185-196. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.185-196 Index. décimale : PER Périodiques Résumé : Purpose Relative age within the school year ( ˜relative age’) is associated with increased rates of symptoms and diagnoses of mental health disorders, including ADHD. We aimed to investigate how relative age influences mental health and behaviour before, during and after school (age range: 4-25 years). Method We used a regression discontinuity design to examine the effect of relative age on risk of mental health problems using data from a large UK population-based cohort (Avon Longitudinal Study of Parents and Children (ALSPAC); N=14,643). We compared risk of mental health problems between ages 4 and 25 years using the parent-rated Strengths and Difficulties Questionnaire (SDQ), and depression using self-rated and parent-rated Short Mood and Feelings Questionnaire (SMFQ) by relative age. Results The youngest children in the school year have greater parent-rated risk of mental health problems, measured using parent-rated SDQ total difficulties scores. We found no evidence of differences before school entry [estimated standardised mean difference (SMD) between those born on 31 August and 1 September: .02 (â’.05, .08)]. We found that estimates of effect size for a 1-year difference in relative age were greatest at 11 years [SMD: .22 (.15, .29)], but attenuated to the null at 25 years [SMD: â’.02 (â’.11, .07)]. We did not find consistent evidence of differences in self-rated and parent-rated depression by relative age. Conclusions Younger relative age is associated with poorer parent-rated general mental health, but not symptoms of depression. En ligne : https://doi.org/10.1111/jcpp.13684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

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