- <Centre d'Information et de documentation du CRA Rhône-Alpes
- CRA
- Informations pratiques
-
Adresse
Centre d'information et de documentation
Horaires
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexLundi au Vendredi
Contact
9h00-12h00 13h30-16h00Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Adresse
Auteur Erik Lykke MORTENSEN
|
|
Documents disponibles écrits par cet auteur (11)
Faire une suggestion Affiner la rechercheAmniotic Fluid MMP-9 and Neurotrophins in Autism Spectrum Disorders: An Exploratory Study / Morsi W. ABDALLAH in Autism Research, 5-6 (December 2012)
Titre : Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study Type de document : texte imprimé Auteurs : Manhai LONG, Auteur ; M. GHISARI, Auteur ; L. KJELDSEN, Auteur ; M. WIELSOE, Auteur ; B. NORGAARD-PEDERSEN, Auteur ; Erik Lykke MORTENSEN, Auteur ; Morsi W. ABDALLAH, Auteur ; E.C. BONEFELD-JORGENSEN, Auteur Article en page(s) : 1 p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Amniotic Fluid/*chemistry Animals Autism Spectrum Disorder/epidemiology/*etiology CHO Cells Case-Control Studies Child Cricetinae Cricetulus Endocrine Disruptors/*analysis/toxicity Female Humans Infant, Newborn Male Metals, Heavy/*analysis/toxicity Middle Aged *Amniotic fluid *Autism *Endocrine disrupting compounds *Receptor activity Newborn Screening Biobank and the Danish Data Protection Agency (Record No. 2009-41-3173) as well as the Central Denmark Region Ethics Committee on Health Research (Record No. M-20090066). Since all data were obtained retrospectively in an anonymized manner, there was no need to obtain consent from any of the participants.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Evidence has indicated that some non-inherited factors such as exposure to environmental pollutants are associated with neurodevelopment disorders like autism spectrum disorder (ASD). Studies report that endocrine disrupting compounds (EDCs), including polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances (PFAS), and some metals, have adverse effects on the fetal neurodevelopment. The aim of this study was to measure the amniotic fluid (AF) levels of EDCs and metals as well as the receptor transactivities induced by AF and investigate the possible link between prenatal exposure to EDCs and heavy metals and ASD risk. Methods: In this case-control study, we included AF samples of 75 ASD cases and 135 frequency-matched controls and measured the levels of the endogenous sex hormones, PFAS, and elements including heavy metals. The combined effect of endogenous hormones and EDCs on the receptor of estrogen (ER), androgen (AR), aryl hydrocarbon (AhR), and thyroid hormone-like activity were also determined and expressed as receptor ligand equivalents. We assessed the associations of AF levels of chemicals, sex hormones, and receptor activities with ASD risk using unconditional logistical regression analyses. To control for multiple comparisons, the false discovery rate (FDR) was used and q values less than 0.25 were designated as statistical significance. Results: PFAS and metals were detectable in AF samples. The ASD cases had significantly lower AF levels of PFAS than controls, and the adjusted odds ratio (OR) was 0.410 (95% CI 0.174, 0.967; p = 0.042; FDR q value = 0.437) for perfluorooctane sulfonate (PFOS). The principal component, including PFAS congeners, copper, iron, and estrogenic activity, was significantly inversely associated with ASD risk (adjusted OR = 0.100; 95% CI 0.016, 0.630; p = 0.014; FDR q value = 0.098).Testosterone level in AF weakly associated with ASD risk (adjusted OR = 1.002; 95% CI 1.000, 1.004; p = 0.05). However, after multiple comparison correction, the association was not significant (FDR q value = 0.437). No significant associations between AF-induced receptor transactivities and ASD risk were observed. The adjusted OR was 2.176 (95%CI 0.115, 41.153) for the ratio of the combined androgenic activity to combined estrogenic activity. Conclusions: The presence of PFAS and heavy metals in AF indicates that they can cross the placenta. The inverse association between levels of PFAS congeners in AF and ASD risk might relate to the weak estrogenic activities and anti-androgenic activities of PFAS.The observed tendency of positive association between the ratio of combined androgenic effect to the combined estrogenic effect and ASD risk needs further studies to explore whether EDCs together with endogenous hormones play a role in the development of ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0253-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 10 (2019) . - 1 p.[article] Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study [texte imprimé] / Manhai LONG, Auteur ; M. GHISARI, Auteur ; L. KJELDSEN, Auteur ; M. WIELSOE, Auteur ; B. NORGAARD-PEDERSEN, Auteur ; Erik Lykke MORTENSEN, Auteur ; Morsi W. ABDALLAH, Auteur ; E.C. BONEFELD-JORGENSEN, Auteur . - 1 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 1 p.
Mots-clés : Adolescent Adult Amniotic Fluid/*chemistry Animals Autism Spectrum Disorder/epidemiology/*etiology CHO Cells Case-Control Studies Child Cricetinae Cricetulus Endocrine Disruptors/*analysis/toxicity Female Humans Infant, Newborn Male Metals, Heavy/*analysis/toxicity Middle Aged *Amniotic fluid *Autism *Endocrine disrupting compounds *Receptor activity Newborn Screening Biobank and the Danish Data Protection Agency (Record No. 2009-41-3173) as well as the Central Denmark Region Ethics Committee on Health Research (Record No. M-20090066). Since all data were obtained retrospectively in an anonymized manner, there was no need to obtain consent from any of the participants.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Evidence has indicated that some non-inherited factors such as exposure to environmental pollutants are associated with neurodevelopment disorders like autism spectrum disorder (ASD). Studies report that endocrine disrupting compounds (EDCs), including polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances (PFAS), and some metals, have adverse effects on the fetal neurodevelopment. The aim of this study was to measure the amniotic fluid (AF) levels of EDCs and metals as well as the receptor transactivities induced by AF and investigate the possible link between prenatal exposure to EDCs and heavy metals and ASD risk. Methods: In this case-control study, we included AF samples of 75 ASD cases and 135 frequency-matched controls and measured the levels of the endogenous sex hormones, PFAS, and elements including heavy metals. The combined effect of endogenous hormones and EDCs on the receptor of estrogen (ER), androgen (AR), aryl hydrocarbon (AhR), and thyroid hormone-like activity were also determined and expressed as receptor ligand equivalents. We assessed the associations of AF levels of chemicals, sex hormones, and receptor activities with ASD risk using unconditional logistical regression analyses. To control for multiple comparisons, the false discovery rate (FDR) was used and q values less than 0.25 were designated as statistical significance. Results: PFAS and metals were detectable in AF samples. The ASD cases had significantly lower AF levels of PFAS than controls, and the adjusted odds ratio (OR) was 0.410 (95% CI 0.174, 0.967; p = 0.042; FDR q value = 0.437) for perfluorooctane sulfonate (PFOS). The principal component, including PFAS congeners, copper, iron, and estrogenic activity, was significantly inversely associated with ASD risk (adjusted OR = 0.100; 95% CI 0.016, 0.630; p = 0.014; FDR q value = 0.098).Testosterone level in AF weakly associated with ASD risk (adjusted OR = 1.002; 95% CI 1.000, 1.004; p = 0.05). However, after multiple comparison correction, the association was not significant (FDR q value = 0.437). No significant associations between AF-induced receptor transactivities and ASD risk were observed. The adjusted OR was 2.176 (95%CI 0.115, 41.153) for the ratio of the combined androgenic activity to combined estrogenic activity. Conclusions: The presence of PFAS and heavy metals in AF indicates that they can cross the placenta. The inverse association between levels of PFAS congeners in AF and ASD risk might relate to the weak estrogenic activities and anti-androgenic activities of PFAS.The observed tendency of positive association between the ratio of combined androgenic effect to the combined estrogenic effect and ASD risk needs further studies to explore whether EDCs together with endogenous hormones play a role in the development of ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0253-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
Titre : Brief Report: Cognitive Flexibility and Focused Attention in Children and Adolescents with Asperger Syndrome or High-Functioning Autism as Measured on the Computerized Version of the Wisconsin Card Sorting Test Type de document : texte imprimé Auteurs : Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur Année de publication : 2008 Article en page(s) : p.1161-1165 Langues : Anglais (eng) Mots-clés : Asperger-syndrome High-functioning-autism Executive-function Wisconsin-Card-Sorting-Test Attention-problems Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess mental flexibility and set maintenance of a group of individuals with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13; mean age 16,4), as compared with a matched group of typically developing children and adolescents (N = 13; mean age 15,6) on the computerized version of the Wisconsin Card Sorting Test (WCST). The participants in the AS/HFA group performed less well than the controls on all categories of the WCST, but the differences did not reach conventional statistical significance on most categories of the WCST. On the category failure to maintain set, however, the AS/HFA participants performed significantly less well than the controls, suggesting a deficit of focused attention. En ligne : http://dx.doi.org/10.1007/s10803-007-0474-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1161-1165[article] Brief Report: Cognitive Flexibility and Focused Attention in Children and Adolescents with Asperger Syndrome or High-Functioning Autism as Measured on the Computerized Version of the Wisconsin Card Sorting Test [texte imprimé] / Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur . - 2008 . - p.1161-1165.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1161-1165
Mots-clés : Asperger-syndrome High-functioning-autism Executive-function Wisconsin-Card-Sorting-Test Attention-problems Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess mental flexibility and set maintenance of a group of individuals with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13; mean age 16,4), as compared with a matched group of typically developing children and adolescents (N = 13; mean age 15,6) on the computerized version of the Wisconsin Card Sorting Test (WCST). The participants in the AS/HFA group performed less well than the controls on all categories of the WCST, but the differences did not reach conventional statistical significance on most categories of the WCST. On the category failure to maintain set, however, the AS/HFA participants performed significantly less well than the controls, suggesting a deficit of focused attention. En ligne : http://dx.doi.org/10.1007/s10803-007-0474-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
Titre : Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder Type de document : texte imprimé Auteurs : Jason SCHIFFMAN, Auteur ; Vijay A. MITTAL, Auteur ; Emily KLINE, Auteur ; Erik Lykke MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur Année de publication : 2015 Article en page(s) : p.1323-1330 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268
in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330[article] Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder [texte imprimé] / Jason SCHIFFMAN, Auteur ; Vijay A. MITTAL, Auteur ; Emily KLINE, Auteur ; Erik Lykke MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur . - 2015 . - p.1323-1330.
Langues : Anglais (eng)
in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330
Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268
Titre : Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism Type de document : texte imprimé Auteurs : Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur Année de publication : 2007 Article en page(s) : p.81-92 Langues : Anglais (eng) Mots-clés : Asperger-syndrome High-functioning-autism Non-social-cognitive-tests Response-times Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess the findings, reported in earlier studies, that individuals with autism spectrum disorders process visuo-spatial tasks faster than typically developing control persons. The participants in the present study were children and adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13), and a matched group of typically developing children and adolescents (N = 13). The results showed that the participants in the clinical group performed marginally less well than those in the control group on both the Block Design Test and the Embedded Figures Test, but the differences were not statistically significant. Thus, earlier findings suggesting that individuals with autism spectrum disorders solve non-social cognitive tasks faster than typically developing control persons were not replicated. The results are discussed with special reference to the hypothesis of weak central coherence. En ligne : http://dx.doi.org/10.1177/1362361307070988 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579
in Autism > 11-1 (January 2007) . - p.81-92[article] Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism [texte imprimé] / Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur . - 2007 . - p.81-92.
Langues : Anglais (eng)
in Autism > 11-1 (January 2007) . - p.81-92
Mots-clés : Asperger-syndrome High-functioning-autism Non-social-cognitive-tests Response-times Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess the findings, reported in earlier studies, that individuals with autism spectrum disorders process visuo-spatial tasks faster than typically developing control persons. The participants in the present study were children and adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13), and a matched group of typically developing children and adolescents (N = 13). The results showed that the participants in the clinical group performed marginally less well than those in the control group on both the Block Design Test and the Embedded Figures Test, but the differences were not statistically significant. Thus, earlier findings suggesting that individuals with autism spectrum disorders solve non-social cognitive tasks faster than typically developing control persons were not replicated. The results are discussed with special reference to the hypothesis of weak central coherence. En ligne : http://dx.doi.org/10.1177/1362361307070988 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579
Permalink
Permalink
Permalink
Permalink
Permalink
Permalink
