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Auteur Yu-Yu WU |
Documents disponibles écrits par cet auteur (18)
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Statistical analysis of twenty years (1993 to 2012) of data from mainland China’s first intervention center for children with autism spectrum disorder / Wei-Zhen ZHOU in Molecular Autism, (November 2014)
[article]
Titre : Statistical analysis of twenty years (1993 to 2012) of data from mainland China’s first intervention center for children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Wei-Zhen ZHOU, Auteur ; Adam Yongxin YE, Auteur ; Zhong-Kai SUN, Auteur ; Hope Huiping TIAN, Auteur ; Tad Zhengzhang PU, Auteur ; Yu-Yu WU, Auteur ; Dan-Dan WANG, Auteur ; Ming-Zhen ZHAO, Auteur ; Shu-Juan LU, Auteur ; Chang-Hong YANG, Auteur ; Liping WEI, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interaction, and restrictive and repetitive patterns of behavior, interests or activities. This study aimed to analyze trends in ASD diagnosis and intervention in 20 years of data from the Beijing Stars and Rain Education Institute for Autism (SR), the first autism intervention center in mainland China, and from a recent survey of members of the Heart Alliance, an industry association of autism intervention centers in China. En ligne : http://dx.doi.org/10.1186/2040-2392-5-52 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276
in Molecular Autism > (November 2014) . - p.1-14[article] Statistical analysis of twenty years (1993 to 2012) of data from mainland China’s first intervention center for children with autism spectrum disorder [Texte imprimé et/ou numérique] / Wei-Zhen ZHOU, Auteur ; Adam Yongxin YE, Auteur ; Zhong-Kai SUN, Auteur ; Hope Huiping TIAN, Auteur ; Tad Zhengzhang PU, Auteur ; Yu-Yu WU, Auteur ; Dan-Dan WANG, Auteur ; Ming-Zhen ZHAO, Auteur ; Shu-Juan LU, Auteur ; Chang-Hong YANG, Auteur ; Liping WEI, Auteur . - p.1-14.
Langues : Anglais (eng)
in Molecular Autism > (November 2014) . - p.1-14
Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interaction, and restrictive and repetitive patterns of behavior, interests or activities. This study aimed to analyze trends in ASD diagnosis and intervention in 20 years of data from the Beijing Stars and Rain Education Institute for Autism (SR), the first autism intervention center in mainland China, and from a recent survey of members of the Heart Alliance, an industry association of autism intervention centers in China. En ligne : http://dx.doi.org/10.1186/2040-2392-5-52 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 Validation of the Mandarin Chinese version of the Autism Diagnostic Observation Schedule-2 for autism spectrum disorder / Mu-Hong CHEN in Research in Autism Spectrum Disorders, 105 (July 2023)
[article]
Titre : Validation of the Mandarin Chinese version of the Autism Diagnostic Observation Schedule-2 for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mu-Hong CHEN, Auteur ; Chi-Fen HUANG, Auteur ; Yu-Siou LIN, Auteur ; Yen-Nan CHIU, Auteur ; Susan Shur-Fen GAU, Auteur ; Yu-Yu WU, Auteur Article en page(s) : 102184 Langues : Anglais (eng) Mots-clés : Autism Diagnostic Observation Schedule Taiwan Validity Effect size Sensitivity Specificity Index. décimale : PER Périodiques Résumé : Background The Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) is a benchmark in the assessment and diagnosis of autism spectrum disorder (ASD) and has been validated in different language settings, including German, Greek, and Korean. However, the diagnostic validity of the Taiwanese Mandarin Chinese version of the ADOS-2 is unknown. Methods The validity of the ADOS-2 was assessed in this study. We enrolled 218 patients, including toddlers, children, adolescents, and adults, with ASD diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The study also enrolled 93 non-ASD controls. The diagnostic sensitivity and specificity of five modules were calculated. Results Based on the total scores of social affect and restricted and repetitive behaviors for the toddler module (MT) and Modules (M) 1-3 and the total score of communication and reciprocal social interaction for M4, we performed a receiver operating characteristic curve analyses, which revealed that the diagnostic specificity of the ADOS-2 ranged between 0.71 for M3 and 1.00 for MT, M1 with few to no words, and M2 with ? 5 years; the diagnostic sensitivity of the ADOS-2 ranged between 0.83 for MT with some words and 0.96 for M1 with few to no words. Discussion This study clinically established the diagnostic validity of the Taiwanese Mandarin Chinese version of the ADOS-2. The ADOS-2 may be used for the assessment and diagnosis of ASD in clinical settings in Taiwan. En ligne : https://doi.org/10.1016/j.rasd.2023.102184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Research in Autism Spectrum Disorders > 105 (July 2023) . - 102184[article] Validation of the Mandarin Chinese version of the Autism Diagnostic Observation Schedule-2 for autism spectrum disorder [Texte imprimé et/ou numérique] / Mu-Hong CHEN, Auteur ; Chi-Fen HUANG, Auteur ; Yu-Siou LIN, Auteur ; Yen-Nan CHIU, Auteur ; Susan Shur-Fen GAU, Auteur ; Yu-Yu WU, Auteur . - 102184.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 105 (July 2023) . - 102184
Mots-clés : Autism Diagnostic Observation Schedule Taiwan Validity Effect size Sensitivity Specificity Index. décimale : PER Périodiques Résumé : Background The Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) is a benchmark in the assessment and diagnosis of autism spectrum disorder (ASD) and has been validated in different language settings, including German, Greek, and Korean. However, the diagnostic validity of the Taiwanese Mandarin Chinese version of the ADOS-2 is unknown. Methods The validity of the ADOS-2 was assessed in this study. We enrolled 218 patients, including toddlers, children, adolescents, and adults, with ASD diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The study also enrolled 93 non-ASD controls. The diagnostic sensitivity and specificity of five modules were calculated. Results Based on the total scores of social affect and restricted and repetitive behaviors for the toddler module (MT) and Modules (M) 1-3 and the total score of communication and reciprocal social interaction for M4, we performed a receiver operating characteristic curve analyses, which revealed that the diagnostic specificity of the ADOS-2 ranged between 0.71 for M3 and 1.00 for MT, M1 with few to no words, and M2 with ? 5 years; the diagnostic sensitivity of the ADOS-2 ranged between 0.83 for MT with some words and 0.96 for M1 with few to no words. Discussion This study clinically established the diagnostic validity of the Taiwanese Mandarin Chinese version of the ADOS-2. The ADOS-2 may be used for the assessment and diagnosis of ASD in clinical settings in Taiwan. En ligne : https://doi.org/10.1016/j.rasd.2023.102184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities / Chun-Hung YEH in Molecular Autism, 13 (2022)
[article]
Titre : White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities Type de document : Texte imprimé et/ou numérique Auteurs : Chun-Hung YEH, Auteur ; Rung-Yu TSENG, Auteur ; Hsing-Chang NI, Auteur ; Luca COCCHI, Auteur ; Jung-Chi CHANG, Auteur ; Mei-Yun HSU, Auteur ; En-Nien TU, Auteur ; Yu-Yu WU, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : 21 p. Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/diagnostic imaging/pathology Autistic Disorder/diagnostic imaging/pathology Brain/diagnostic imaging/pathology Corpus Callosum/diagnostic imaging Diffusion Magnetic Resonance Imaging/methods Humans White Matter/diagnostic imaging/pathology Autism spectrum disorder Cerebellum Diffusion MRI Fixel-based analysis Intellectual disabilities Minimally verbal status Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimage literature of autism spectrum disorder (ASD) has a moderate-to-high risk of bias, partially because those combined with intellectual impairment (II) and/or minimally verbal (MV) status are generally ignored. We aimed to provide more comprehensive insights into white matter alterations of ASD, inclusive of individuals with II (ASD-II-Only) or MV expression (ASD-MV). METHODS: Sixty-five participants with ASD (ASD-Whole; 16.6?+?5.9 years; comprising 34 intellectually able youth, ASD-IA, and 31 intellectually impaired youth, ASD-II, including 24 ASD-II-Only plus 7 ASD-MV) and 38 demographic-matched typically developing controls (TDC; 17.3?+?5.6 years) were scanned in accelerated diffusion-weighted MRI. Fixel-based analysis was undertaken to investigate the categorical differences in fiber density (FD), fiber cross section (FC), and a combined index (FDC), and brain symptom/cognition associations. RESULTS: ASD-Whole had reduced FD in the anterior and posterior corpus callosum and left cerebellum Crus I, and smaller FDC in right cerebellum Crus II, compared to TDC. ASD-IA, relative to TDC, had no significant discrepancies, while ASD-II showed almost identical alterations to those from ASD-Whole vs. TDC. ASD-II-Only had greater FD/FDC in the isthmus splenium of callosum than ASD-MV. Autistic severity negatively correlated with FC in right Crus I. Nonverbal full-scale IQ positively correlated with FC/FDC in cerebellum VI. FD/FDC of the right dorsolateral prefrontal cortex showed a diagnosis-by-executive function interaction. LIMITATIONS: We could not preclude the potential effects of age and sex from the ASD cohort, although statistical tests suggested that these factors were not influential. Our results could be confounded by variable psychiatric comorbidities and psychotropic medication uses in our ASD participants recruited from outpatient clinics, which is nevertheless closer to a real-world presentation of ASD. The outcomes related to ASD-MV were considered preliminaries due to the small sample size within this subgroup. Finally, our study design did not include intellectual impairment-only participants without ASD to disentangle the mixture of autistic and intellectual symptoms. CONCLUSIONS: ASD-associated white matter alterations appear driven by individuals with II and potentially further by MV. Results suggest that changes in the corpus callosum and cerebellum are key for psychopathology and cognition associated with ASD. Our work highlights an essential to include understudied subpopulations on the spectrum in research. En ligne : http://dx.doi.org/10.1186/s13229-022-00499-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Molecular Autism > 13 (2022) . - 21 p.[article] White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities [Texte imprimé et/ou numérique] / Chun-Hung YEH, Auteur ; Rung-Yu TSENG, Auteur ; Hsing-Chang NI, Auteur ; Luca COCCHI, Auteur ; Jung-Chi CHANG, Auteur ; Mei-Yun HSU, Auteur ; En-Nien TU, Auteur ; Yu-Yu WU, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiang-Yuan LIN, Auteur . - 21 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 21 p.
Mots-clés : Adolescent Autism Spectrum Disorder/diagnostic imaging/pathology Autistic Disorder/diagnostic imaging/pathology Brain/diagnostic imaging/pathology Corpus Callosum/diagnostic imaging Diffusion Magnetic Resonance Imaging/methods Humans White Matter/diagnostic imaging/pathology Autism spectrum disorder Cerebellum Diffusion MRI Fixel-based analysis Intellectual disabilities Minimally verbal status Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimage literature of autism spectrum disorder (ASD) has a moderate-to-high risk of bias, partially because those combined with intellectual impairment (II) and/or minimally verbal (MV) status are generally ignored. We aimed to provide more comprehensive insights into white matter alterations of ASD, inclusive of individuals with II (ASD-II-Only) or MV expression (ASD-MV). METHODS: Sixty-five participants with ASD (ASD-Whole; 16.6?+?5.9 years; comprising 34 intellectually able youth, ASD-IA, and 31 intellectually impaired youth, ASD-II, including 24 ASD-II-Only plus 7 ASD-MV) and 38 demographic-matched typically developing controls (TDC; 17.3?+?5.6 years) were scanned in accelerated diffusion-weighted MRI. Fixel-based analysis was undertaken to investigate the categorical differences in fiber density (FD), fiber cross section (FC), and a combined index (FDC), and brain symptom/cognition associations. RESULTS: ASD-Whole had reduced FD in the anterior and posterior corpus callosum and left cerebellum Crus I, and smaller FDC in right cerebellum Crus II, compared to TDC. ASD-IA, relative to TDC, had no significant discrepancies, while ASD-II showed almost identical alterations to those from ASD-Whole vs. TDC. ASD-II-Only had greater FD/FDC in the isthmus splenium of callosum than ASD-MV. Autistic severity negatively correlated with FC in right Crus I. Nonverbal full-scale IQ positively correlated with FC/FDC in cerebellum VI. FD/FDC of the right dorsolateral prefrontal cortex showed a diagnosis-by-executive function interaction. LIMITATIONS: We could not preclude the potential effects of age and sex from the ASD cohort, although statistical tests suggested that these factors were not influential. Our results could be confounded by variable psychiatric comorbidities and psychotropic medication uses in our ASD participants recruited from outpatient clinics, which is nevertheless closer to a real-world presentation of ASD. The outcomes related to ASD-MV were considered preliminaries due to the small sample size within this subgroup. Finally, our study design did not include intellectual impairment-only participants without ASD to disentangle the mixture of autistic and intellectual symptoms. CONCLUSIONS: ASD-associated white matter alterations appear driven by individuals with II and potentially further by MV. Results suggest that changes in the corpus callosum and cerebellum are key for psychopathology and cognition associated with ASD. Our work highlights an essential to include understudied subpopulations on the spectrum in research. En ligne : http://dx.doi.org/10.1186/s13229-022-00499-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477