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Faire une suggestionBetter fear conditioning is associated with reduced symptom severity in autism spectrum disorders / Mikle SOUTH in Autism Research, 4-6 (December 2011)
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Titre : Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders Type de document : texte imprimé Auteurs : Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur Année de publication : 2012 Article en page(s) : p.412-421 Langues : Anglais (eng) Mots-clés : autism spectrum disorders amygdala anxiety fear conditioning dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Autism Research > 4-6 (December 2011) . - p.412-421[article] Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders [texte imprimé] / Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur . - 2012 . - p.412-421.
Langues : Anglais (eng)
in Autism Research > 4-6 (December 2011) . - p.412-421
Mots-clés : autism spectrum disorders amygdala anxiety fear conditioning dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 Brief Report: The Broad Autism Phenotype in Swedish Parents of Children With and Without Autism Spectrum Conditions / Peter BANG in Journal of Autism and Developmental Disorders, 52-10 (October 2022)
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Titre : Brief Report: The Broad Autism Phenotype in Swedish Parents of Children With and Without Autism Spectrum Conditions Type de document : texte imprimé Auteurs : Peter BANG, Auteur ; Maria STROMBERG, Auteur ; Shoba S. MEERA, Auteur ; Kajsa IGELSTROM, Auteur Article en page(s) : p.4575-4582 Langues : Anglais (eng) Mots-clés : Autistic traits Confirmatory factor analysis Dimensional measures Instrument translation Index. décimale : PER Périodiques Résumé : The broad autism phenotype (BAP) is a set of characteristics often observed in typically developing people with a genetic load for autism, such as parents of autistic children. The Broad Autism Phenotypic Questionnaire (BAPQ) is a 36-item questionnaire developed to identify the BAP in first-degree relatives of autistic people. We translated the BAPQ into Swedish and examined its psychometric properties in a Swedish sample consisting of 45 parents of children with ASC and 74 parents of non-autistic children. We found support for the original 3-factor structure (aloof, pragmatic language and rigid), good internal consistency and convergent validity with the Autism Quotient. Thus, the Swedish BAPQ exhibits acceptable psychometric properties and may be useful for assessing the BAP in non-clinical populations. En ligne : http://dx.doi.org/10.1007/s10803-021-05302-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4575-4582[article] Brief Report: The Broad Autism Phenotype in Swedish Parents of Children With and Without Autism Spectrum Conditions [texte imprimé] / Peter BANG, Auteur ; Maria STROMBERG, Auteur ; Shoba S. MEERA, Auteur ; Kajsa IGELSTROM, Auteur . - p.4575-4582.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4575-4582
Mots-clés : Autistic traits Confirmatory factor analysis Dimensional measures Instrument translation Index. décimale : PER Périodiques Résumé : The broad autism phenotype (BAP) is a set of characteristics often observed in typically developing people with a genetic load for autism, such as parents of autistic children. The Broad Autism Phenotypic Questionnaire (BAPQ) is a 36-item questionnaire developed to identify the BAP in first-degree relatives of autistic people. We translated the BAPQ into Swedish and examined its psychometric properties in a Swedish sample consisting of 45 parents of children with ASC and 74 parents of non-autistic children. We found support for the original 3-factor structure (aloof, pragmatic language and rigid), good internal consistency and convergent validity with the Autism Quotient. Thus, the Swedish BAPQ exhibits acceptable psychometric properties and may be useful for assessing the BAP in non-clinical populations. En ligne : http://dx.doi.org/10.1007/s10803-021-05302-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 Sensory symptoms associated with autistic traits and anxiety levels in children aged 6-11 years / Peter BANG in Journal of Neurodevelopmental Disorders, 16 (2024)
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Titre : Sensory symptoms associated with autistic traits and anxiety levels in children aged 6-11 years Type de document : texte imprimé Auteurs : Peter BANG, Auteur ; Danait Kidane ANDEMICHAEL, Auteur ; Johan F. PIESLINGER, Auteur ; Kajsa IGELSTROM, Auteur Langues : Anglais (eng) Mots-clés : Humans Female Child Male Anxiety Autism Spectrum Disorder/complications/physiopathology Sensation Disorders/etiology/physiopathology Autistic Disorder/complications/physiopathology Broad autistic phenotype Central auditory processing disorder Developmental Coordination Disorder Questionnaire Dimensional measures Glasgow sensory questionnaire Hyperacusis Research Domain Criteria Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (ASC) and quantitative autistic traits (QATs) are associated with sensory symptoms, which may contribute to anxiety and adversely affect social and cognitive development. Although sensory symptoms can occur across all senses, the relative roles of specific sensory modalities as contributors to the autistic phenotype and to anxiety are not well understood. The objective of this study was to examine which sensory symptoms were most predictive of high anxiety. METHODS: We recruited 257 female primary caregivers of children aged 6 to 11 years (49% girls) to a questionnaire study comprising parent-report measures for classical QATs (social, communicative, and rigid), autism-related sensorimotor symptoms (visual, auditory, tactile, olfactory, gustatory, vestibular, proprioceptive, and motor), and anxiety symptoms. First, Bayesian stochastic search variable selection (SSVS) was used to identify the most probable sensorimotor predictors of specific QATs as well as diagnosed ASC. Then, the selected predictors were used in another SSVS, using anxiety symptoms as a dependent variable, to identify which of the autism-relevant sensorimotor symptoms were most robustly predictive of anxiety. Finally, the effect sizes of anxiety-related sensory symptoms were estimated with linear regressions. RESULTS: We found that auditory symptoms and motor difficulties were most predictive of ASC diagnosis. Developmental motor difficulties were also strongly related to all individual QATs, whereas auditory symptoms were more selectively predictive of rigid traits. Tactile symptoms robustly predicted social interaction QATs, and proprioceptive symptoms predicted communicative QATs. Anxiety outcomes were most strongly predicted by difficulties with auditory and olfactory processing. CONCLUSIONS: The results support the clinical importance of being alert to complaints about sounds and hearing in neurodevelopmental populations, and that auditory processing difficulties may be evaluated as an early marker of poor mental health in children with and without diagnosed autism. Olfactory processing differences appeared to be an anxiety marker less strongly associated with ASC or QATs, while motor difficulties were highly autism-relevant but not equally strongly associated with anxiety outcomes. We suggest that future studies may focus on the mechanisms and consequences of neurodevelopmental central auditory processing dysfunction and its potential relationship to anxiety disorders. En ligne : https://dx.doi.org/10.1186/s11689-024-09562-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575
in Journal of Neurodevelopmental Disorders > 16 (2024)[article] Sensory symptoms associated with autistic traits and anxiety levels in children aged 6-11 years [texte imprimé] / Peter BANG, Auteur ; Danait Kidane ANDEMICHAEL, Auteur ; Johan F. PIESLINGER, Auteur ; Kajsa IGELSTROM, Auteur.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 16 (2024)
Mots-clés : Humans Female Child Male Anxiety Autism Spectrum Disorder/complications/physiopathology Sensation Disorders/etiology/physiopathology Autistic Disorder/complications/physiopathology Broad autistic phenotype Central auditory processing disorder Developmental Coordination Disorder Questionnaire Dimensional measures Glasgow sensory questionnaire Hyperacusis Research Domain Criteria Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (ASC) and quantitative autistic traits (QATs) are associated with sensory symptoms, which may contribute to anxiety and adversely affect social and cognitive development. Although sensory symptoms can occur across all senses, the relative roles of specific sensory modalities as contributors to the autistic phenotype and to anxiety are not well understood. The objective of this study was to examine which sensory symptoms were most predictive of high anxiety. METHODS: We recruited 257 female primary caregivers of children aged 6 to 11 years (49% girls) to a questionnaire study comprising parent-report measures for classical QATs (social, communicative, and rigid), autism-related sensorimotor symptoms (visual, auditory, tactile, olfactory, gustatory, vestibular, proprioceptive, and motor), and anxiety symptoms. First, Bayesian stochastic search variable selection (SSVS) was used to identify the most probable sensorimotor predictors of specific QATs as well as diagnosed ASC. Then, the selected predictors were used in another SSVS, using anxiety symptoms as a dependent variable, to identify which of the autism-relevant sensorimotor symptoms were most robustly predictive of anxiety. Finally, the effect sizes of anxiety-related sensory symptoms were estimated with linear regressions. RESULTS: We found that auditory symptoms and motor difficulties were most predictive of ASC diagnosis. Developmental motor difficulties were also strongly related to all individual QATs, whereas auditory symptoms were more selectively predictive of rigid traits. Tactile symptoms robustly predicted social interaction QATs, and proprioceptive symptoms predicted communicative QATs. Anxiety outcomes were most strongly predicted by difficulties with auditory and olfactory processing. CONCLUSIONS: The results support the clinical importance of being alert to complaints about sounds and hearing in neurodevelopmental populations, and that auditory processing difficulties may be evaluated as an early marker of poor mental health in children with and without diagnosed autism. Olfactory processing differences appeared to be an anxiety marker less strongly associated with ASC or QATs, while motor difficulties were highly autism-relevant but not equally strongly associated with anxiety outcomes. We suggest that future studies may focus on the mechanisms and consequences of neurodevelopmental central auditory processing dysfunction and its potential relationship to anxiety disorders. En ligne : https://dx.doi.org/10.1186/s11689-024-09562-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

