[article]
| Titre : |
Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
David H. SKUSE, Auteur |
| Année de publication : |
2000 |
| Article en page(s) : |
p.3-31 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Behavioural neuroscience neurogenetics model systems Drosophila melanogaster Caenorhabditis elegans laboratory mouse |
| Index. décimale : |
PER Périodiques |
| Résumé : |
We have just emerged from “the Decade of the Brain”, yet in so many ways it was the “Decade of the Genome”. What relevance does the remarkable advance in knowledge in genetics and neuroscience over that period have to our understanding of child psychopathology? When the complexity of the genetic systems involved in behavioural regulation of relatively simple organisms such as the nematode worm Caenorhabditis elegans or the fruitfly Drosophila melanogaster is considered, the possibility of comprehending the links from genes to behaviour in the developing child seems remote. Yet, the principles of investigation in model systems are not so different to those that should apply in humans. This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 |
in Journal of Child Psychology and Psychiatry > 41-1 (January 2000) . - p.3-31
[article] Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems [Texte imprimé et/ou numérique] / David H. SKUSE, Auteur . - 2000 . - p.3-31. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 41-1 (January 2000) . - p.3-31
| Mots-clés : |
Behavioural neuroscience neurogenetics model systems Drosophila melanogaster Caenorhabditis elegans laboratory mouse |
| Index. décimale : |
PER Périodiques |
| Résumé : |
We have just emerged from “the Decade of the Brain”, yet in so many ways it was the “Decade of the Genome”. What relevance does the remarkable advance in knowledge in genetics and neuroscience over that period have to our understanding of child psychopathology? When the complexity of the genetic systems involved in behavioural regulation of relatively simple organisms such as the nematode worm Caenorhabditis elegans or the fruitfly Drosophila melanogaster is considered, the possibility of comprehending the links from genes to behaviour in the developing child seems remote. Yet, the principles of investigation in model systems are not so different to those that should apply in humans. This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 |
|
Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems in Journal of Child Psychology and Psychiatry, 41-1 (January 2000)