Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder / Pamela B. JACKSON in Autism Research, 2-4 (August 2009)  

Public ISBD [article]  inAutism Research > 2-4 (August 2009) . - p.232-236 Titre : Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder Type de document : Texte imprimé et/ou numérique Auteurs : Pamela B. JACKSON, Auteur ; Luigi BOCCUTO, Auteur ; Cindy SKINNER, Auteur ; Julianne S. COLLINS, Auteur ; Giovanni NERI, Auteur ; Fiorella GURRIERI, Auteur ; Charles E. SCHWARTZ, Auteur Année de publication : 2009 Article en page(s) : p.232-236 Langues : Anglais (eng) Mots-clés : autism autistic-disorder MET PDD PDD-NOS Index. décimale : PER Périodiques Résumé : Previous studies in three independent cohorts have shown that the rs1858830 C allele variant in the promoter region of the MET gene on chromosome 7q31 is associated with autism. Another study has found correlations between other alterations in the MET gene and autism in two unrelated cohorts. This study screened two cohorts, an Autistic Disorder cohort from South Carolina and a Pervasive Developmental Disorder (PDD) cohort from Italy, for the presence of the C allele variant in rs1858830. A significant increase in the C allele variant frequency was found in the South Carolina Autistic Disorder patients as compared to South Carolina Controls (2=5.8, df=1, P=0.02). In the South Carolina cohort, a significant association with Autistic Disorder was found when comparing the CC and CG genotypes to the GG genotype (odds ratio (OR)=1.64; 95% confidence interval (CI)=1.12-2.40; 2=6.5, df=1, P=0.01) in cases and controls. In the Italian cohort, no significant association with PDD was found when comparing the CC or CG genotype to the GG genotype (OR=1.20; 95% CI=0.56-2.56; 2=0.2, df=1, P=0.64). This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism. En ligne : http://dx.doi.org/10.1002/aur.87 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder [Texte imprimé et/ou numérique] / Pamela B. JACKSON, Auteur ; Luigi BOCCUTO, Auteur ; Cindy SKINNER, Auteur ; Julianne S. COLLINS, Auteur ; Giovanni NERI, Auteur ; Fiorella GURRIERI, Auteur ; Charles E. SCHWARTZ, Auteur . - 2009 . - p.232-236. Langues : Anglais (eng) in Autism Research > 2-4 (August 2009) . - p.232-236 Mots-clés : autism autistic-disorder MET PDD PDD-NOS Index. décimale : PER Périodiques Résumé : Previous studies in three independent cohorts have shown that the rs1858830 C allele variant in the promoter region of the MET gene on chromosome 7q31 is associated with autism. Another study has found correlations between other alterations in the MET gene and autism in two unrelated cohorts. This study screened two cohorts, an Autistic Disorder cohort from South Carolina and a Pervasive Developmental Disorder (PDD) cohort from Italy, for the presence of the C allele variant in rs1858830. A significant increase in the C allele variant frequency was found in the South Carolina Autistic Disorder patients as compared to South Carolina Controls (2=5.8, df=1, P=0.02). In the South Carolina cohort, a significant association with Autistic Disorder was found when comparing the CC and CG genotypes to the GG genotype (odds ratio (OR)=1.64; 95% confidence interval (CI)=1.12-2.40; 2=6.5, df=1, P=0.01) in cases and controls. In the Italian cohort, no significant association with PDD was found when comparing the CC or CG genotype to the GG genotype (OR=1.20; 95% CI=0.56-2.56; 2=0.2, df=1, P=0.64). This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism. En ligne : http://dx.doi.org/10.1002/aur.87 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism / Brent C. SATTERFIELD in Molecular Autism, (October 2010)  

Public ISBD [article]  inMolecular Autism > (October 2010) . - 4 p. Titre : PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism Type de document : Texte imprimé et/ou numérique Auteurs : Brent C. SATTERFIELD, Auteur ; Rebecca A. GARCIA, Auteur ; Fiorella GURRIERI, Auteur ; Charles E. SCHWARTZ, Auteur Année de publication : 2010 Article en page(s) : 4 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus implicated in prostate cancer and chronic fatigue syndrome (CFS). Press releases have suggested that it could contribute to autism spectrum disorder (ASD). In this study we used two PCR assays and one antibody assay to screen 25 blood samples from autistic children born to mothers with CFS and from 20 mixed controls including family members of the children assayed, people with fibromyalgia and people with chronic Lyme disease. Using a real-time PCR assay, we screened an additional 48 South Carolina autism disorder samples, 96 Italian ASD samples, 61 South Carolina ASD samples and 184 healthy controls. Despite having the ability to detect low copy number XMRV DNA in a large background of cellular DNA, none of the PCR assays found any evidence of XMRV infection in blood cells from patients or controls. Further, no anti-XMRV antibodies were detected, ruling out possible low level or abortive infections in blood or in other reservoirs. These results imply that XMRV is not associated with autism. En ligne : http://dx.doi.org/10.1186/2040-2392-1-14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism [Texte imprimé et/ou numérique] / Brent C. SATTERFIELD, Auteur ; Rebecca A. GARCIA, Auteur ; Fiorella GURRIERI, Auteur ; Charles E. SCHWARTZ, Auteur . - 2010 . - 4 p. Langues : Anglais (eng) in Molecular Autism > (October 2010) . - 4 p. Index. décimale : PER Périodiques Résumé : Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus implicated in prostate cancer and chronic fatigue syndrome (CFS). Press releases have suggested that it could contribute to autism spectrum disorder (ASD). In this study we used two PCR assays and one antibody assay to screen 25 blood samples from autistic children born to mothers with CFS and from 20 mixed controls including family members of the children assayed, people with fibromyalgia and people with chronic Lyme disease. Using a real-time PCR assay, we screened an additional 48 South Carolina autism disorder samples, 96 Italian ASD samples, 61 South Carolina ASD samples and 184 healthy controls. Despite having the ability to detect low copy number XMRV DNA in a large background of cellular DNA, none of the PCR assays found any evidence of XMRV infection in blood cells from patients or controls. Further, no anti-XMRV antibodies were detected, ruling out possible low level or abortive infections in blood or in other reservoirs. These results imply that XMRV is not associated with autism. En ligne : http://dx.doi.org/10.1186/2040-2392-1-14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

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