[article]
| Titre : |
Independent and dependent contributions of advanced maternal and paternal ages to autism risk |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Janie F. SHELTON, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Daniel J. TANCREDI, Auteur |
| Année de publication : |
2010 |
| Article en page(s) : |
p.30-39 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
autism maternal-age paternal-age effect-measure-modification attributable-risk advanced-maternal-age advanced-paternal-age interaction |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricted strata of parental age in a 10-year California birth cohort to determine the independent or dependent effect from each parent. Autism cases from California Department of Developmental Services records were linked to State birth files (1990-1999). Only singleton births with complete data on parental age and education were included (n=4,947,935, cases=12,159). In multivariate logistic regression models, advancing maternal age increased risk for autism monotonically regardless of the paternal age. Compared with mothers 25-29 years of age, the adjusted odds ratio (aOR) for mothers 40+ years was 1.51 (95% CI: 1.35-1.70), or compared with mothers <25 years of age, aOR=1.77 (95% CI, 1.56-2.00). In contrast, autism risk was associated with advancing paternal age primarily among mothers <30: aOR=1.59 (95% CI, 1.37-1.85) comparing fathers 40+ vs. 25-29 years of age. However, among mothers >30, the aOR was 1.13 (95% CI, 1.01-1.27) for fathers 40+ vs. 25-29 years of age, almost identical to the aOR for fathers <25 years. Based on the first examination of heterogeneity in parental age effects, it appears that women's risk for delivering a child who develops autism increases throughout their reproductive years whereas father's age confers increased risk for autism when mothers are <30, but has little effect when mothers are past age 30. We also calculated that the recent trend towards delayed childbearing contributed approximately a 4.6% increase in autism diagnoses in California over the decade. |
| En ligne : |
http://dx.doi.org/10.1002/aur.116 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 |
in Autism Research > 3-1 (February 2010) . - p.30-39
[article] Independent and dependent contributions of advanced maternal and paternal ages to autism risk [Texte imprimé et/ou numérique] / Janie F. SHELTON, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Daniel J. TANCREDI, Auteur . - 2010 . - p.30-39. Langues : Anglais ( eng) in Autism Research > 3-1 (February 2010) . - p.30-39
| Mots-clés : |
autism maternal-age paternal-age effect-measure-modification attributable-risk advanced-maternal-age advanced-paternal-age interaction |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricted strata of parental age in a 10-year California birth cohort to determine the independent or dependent effect from each parent. Autism cases from California Department of Developmental Services records were linked to State birth files (1990-1999). Only singleton births with complete data on parental age and education were included (n=4,947,935, cases=12,159). In multivariate logistic regression models, advancing maternal age increased risk for autism monotonically regardless of the paternal age. Compared with mothers 25-29 years of age, the adjusted odds ratio (aOR) for mothers 40+ years was 1.51 (95% CI: 1.35-1.70), or compared with mothers <25 years of age, aOR=1.77 (95% CI, 1.56-2.00). In contrast, autism risk was associated with advancing paternal age primarily among mothers <30: aOR=1.59 (95% CI, 1.37-1.85) comparing fathers 40+ vs. 25-29 years of age. However, among mothers >30, the aOR was 1.13 (95% CI, 1.01-1.27) for fathers 40+ vs. 25-29 years of age, almost identical to the aOR for fathers <25 years. Based on the first examination of heterogeneity in parental age effects, it appears that women's risk for delivering a child who develops autism increases throughout their reproductive years whereas father's age confers increased risk for autism when mothers are <30, but has little effect when mothers are past age 30. We also calculated that the recent trend towards delayed childbearing contributed approximately a 4.6% increase in autism diagnoses in California over the decade. |
| En ligne : |
http://dx.doi.org/10.1002/aur.116 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 |
|
Faire une suggestion Affiner la rechercheErratum : Independent and dependent contributions of advanced maternal and paternal ages to autism risk / Janie F. SHELTON in Autism Research, 3-2 (April 2010)
