An Italian Prospective Study on Autism Treatment: The Earlier, the Better? / Giacomo VIVANTI in Autism - Open Access, 1-1 (December 2011)  

Public ISBD [article]  inAutism - Open Access > 1-1 (December 2011) . - 4 p. Titre : An Italian Prospective Study on Autism Treatment: The Earlier, the Better? Type de document : Texte imprimé et/ou numérique Auteurs : Giacomo VIVANTI, Auteur ; Barbara MANZI, Auteur ; Arianna BENVENUTO, Auteur ; Barbara BATTAN, Auteur ; Paolo CURATOLO, Auteur Année de publication : 2011 Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorders  Early diagnosis andtreatment  Cognitive and behavioral outcomes Index. décimale : PER Périodiques Résumé : Background: Neurocognitive models of autism suggest that starting a treatment at a younger age might be a critical factor in promoting optimal outcomes. The aim of the study is to examine the relationship between age at start of treatment and outcomes in a group of children with Autism Spectrum Disorders (ASDs) in Italy. Methods: Thirty-nine children between 22 and 77 months of age diagnosed with ASDs were divided into two groups on the basis of their age at start of a community-based behavioral treatment. Measures of severity of symptoms, cognitive abilities and adaptive functioning were collected at the beginning of the treatment (Time 1) and one year after (Time 2) to examine group differences in treatment outcomes. Our working hypothesis was that children who started the treatment at a younger age would show a more positive response to treatment compared to children who started at later age. Results: Compared with children who received a diagnosis and started the treatment at a later age, children in the early treatment group showed a better outcome in terms of attenuation of symptoms severity. No group differences were found in terms of adaptive functioning and cognitive abilities, with both groups equally improving their performance. Conclusions: Age at start of the treatment seems to be an important factor to promote gains in the social- communication domain. However, gains in adaptive functioning and cognitive skills in our sample were not related to age. The positive effect of a community-based intervention in children with an early diagnosis of ASDs might be due to the plasticity of neural systems in age-dependent stages. The possibility that early intervention could substantially alter the course of behavioral and brain development in children with autism points to the urgent need for more research on treatment in this population. En ligne : http://dx.doi.org/10.4172/2165-7890.1000102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] An Italian Prospective Study on Autism Treatment: The Earlier, the Better? [Texte imprimé et/ou numérique] / Giacomo VIVANTI, Auteur ; Barbara MANZI, Auteur ; Arianna BENVENUTO, Auteur ; Barbara BATTAN, Auteur ; Paolo CURATOLO, Auteur . - 2011 . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 1-1 (December 2011) . - 4 p. Mots-clés : Autism Spectrum Disorders  Early diagnosis andtreatment  Cognitive and behavioral outcomes Index. décimale : PER Périodiques Résumé : Background: Neurocognitive models of autism suggest that starting a treatment at a younger age might be a critical factor in promoting optimal outcomes. The aim of the study is to examine the relationship between age at start of treatment and outcomes in a group of children with Autism Spectrum Disorders (ASDs) in Italy. Methods: Thirty-nine children between 22 and 77 months of age diagnosed with ASDs were divided into two groups on the basis of their age at start of a community-based behavioral treatment. Measures of severity of symptoms, cognitive abilities and adaptive functioning were collected at the beginning of the treatment (Time 1) and one year after (Time 2) to examine group differences in treatment outcomes. Our working hypothesis was that children who started the treatment at a younger age would show a more positive response to treatment compared to children who started at later age. Results: Compared with children who received a diagnosis and started the treatment at a later age, children in the early treatment group showed a better outcome in terms of attenuation of symptoms severity. No group differences were found in terms of adaptive functioning and cognitive abilities, with both groups equally improving their performance. Conclusions: Age at start of the treatment seems to be an important factor to promote gains in the social- communication domain. However, gains in adaptive functioning and cognitive skills in our sample were not related to age. The positive effect of a community-based intervention in children with an early diagnosis of ASDs might be due to the plasticity of neural systems in age-dependent stages. The possibility that early intervention could substantially alter the course of behavioral and brain development in children with autism points to the urgent need for more research on treatment in this population. En ligne : http://dx.doi.org/10.4172/2165-7890.1000102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Autism spectrum disorders associated with chromosomal abnormalities / Adriana LO-CASTRO in Research in Autism Spectrum Disorders, 4-3 (July-September 2010)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 4-3 (July-September 2010) . - p.319-327 Titre : Autism spectrum disorders associated with chromosomal abnormalities Type de document : Texte imprimé et/ou numérique Auteurs : Adriana LO-CASTRO, Auteur ; Paolo CURATOLO, Auteur ; Arianna BENVENUTO, Auteur ; Cinzia GALASSO, Auteur ; Cristina PORFIRIO, Auteur Année de publication : 2010 Article en page(s) : p.319-327 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders Chromosomal-abnormalities Mental-retardation Dysmorphic-features Minor-physical-anomalies Genetics Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) constitute a class of severe neurodevelopmental conditions with complex multifactorial and heterogeneous etiology. Despite high estimates of heritability, genetic causes of ASDs remain elusive, due to a high degree of genetic and phenotypic heterogeneity. So far, several “monogenic” forms of autism have been identified, including Rett syndrome, Fragile-X syndrome, and Tuberous Sclerosis, accounting only for a small part of ASDs cases. Further evidences for rare mutations in the etiology of ASDs come from cytogenetic studies. Traditional cytogenetic approaches have highlighted the high frequency of large chromosomal abnormalities (about 7% of patients) and, more recently, the advent of high-resolution oligonucleotide microarrays has made possible to screen genome-wide for structural changes. In this review, we describe less known chromosomal abnormalities reported in association with ASDs and provide some clues to neuropediatricians for a more specific diagnostic evaluation of patients with ASDs. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.10.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=100 [article] Autism spectrum disorders associated with chromosomal abnormalities [Texte imprimé et/ou numérique] / Adriana LO-CASTRO, Auteur ; Paolo CURATOLO, Auteur ; Arianna BENVENUTO, Auteur ; Cinzia GALASSO, Auteur ; Cristina PORFIRIO, Auteur . - 2010 . - p.319-327. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 4-3 (July-September 2010) . - p.319-327 Mots-clés : Autism-spectrum-disorders Chromosomal-abnormalities Mental-retardation Dysmorphic-features Minor-physical-anomalies Genetics Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) constitute a class of severe neurodevelopmental conditions with complex multifactorial and heterogeneous etiology. Despite high estimates of heritability, genetic causes of ASDs remain elusive, due to a high degree of genetic and phenotypic heterogeneity. So far, several “monogenic” forms of autism have been identified, including Rett syndrome, Fragile-X syndrome, and Tuberous Sclerosis, accounting only for a small part of ASDs cases. Further evidences for rare mutations in the etiology of ASDs come from cytogenetic studies. Traditional cytogenetic approaches have highlighted the high frequency of large chromosomal abnormalities (about 7% of patients) and, more recently, the advent of high-resolution oligonucleotide microarrays has made possible to screen genome-wide for structural changes. In this review, we describe less known chromosomal abnormalities reported in association with ASDs and provide some clues to neuropediatricians for a more specific diagnostic evaluation of patients with ASDs. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.10.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=100

---

1 (1 - 2 / 2)