Infant head growth in male siblings of children with and without autism spectrum disorders / John N. CONSTANTINO in Journal of Neurodevelopmental Disorders, 2-1 (March 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-1 (March 2010) . - p.39-46 Titre : Infant head growth in male siblings of children with and without autism spectrum disorders Type de document : texte imprimé Auteurs : John N. CONSTANTINO, Auteur ; Palak MAJMUDAR, Auteur ; Alex BOTTINI, Auteur ; Molly ARVIN, Auteur ; Yamini VIRKUD, Auteur ; Paul SIMONS, Auteur ; Ed SPITZNAGEL, Auteur Article en page(s) : p.39-46 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : PURPOSE: Previous research has indicated that children with autism exhibit accelerated head growth (HG) in infancy, although the timing of acceleration varies between studies. We examined infant HG trajectory as a candidate autism endophenotype by studying sibling pairs. METHODS: We retrospectively obtained serial head orbitofrontal circumference measurements of: a) 48 sibling pairs in which one (n=28) or both (n=20) sibs were affected by an autism spectrum disorder (ASD); and b) 85 control male sibling pairs. RESULTS: Rate of HG of ASD subjects was slightly accelerated compared to controls, but the magnitude of difference was below the limit of reliability of standard measurement methods. Sibling intra class correlation for rate of HG was highly statistically significant; the magnitude was significantly stronger among autism-affected families (ICC=.63) than among controls (ICC=.26), p<.01. CONCLUSION: Infant HG trajectory appears familial-possibly endophenotypic-but was not a reliable marker of autism risk among siblings of ASD probands in this sample. En ligne : http://dx.doi.org/10.1007/s11689-009-9036-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Infant head growth in male siblings of children with and without autism spectrum disorders [texte imprimé] / John N. CONSTANTINO, Auteur ; Palak MAJMUDAR, Auteur ; Alex BOTTINI, Auteur ; Molly ARVIN, Auteur ; Yamini VIRKUD, Auteur ; Paul SIMONS, Auteur ; Ed SPITZNAGEL, Auteur . - p.39-46. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-1 (March 2010) . - p.39-46 Index. décimale : PER Périodiques Résumé : PURPOSE: Previous research has indicated that children with autism exhibit accelerated head growth (HG) in infancy, although the timing of acceleration varies between studies. We examined infant HG trajectory as a candidate autism endophenotype by studying sibling pairs. METHODS: We retrospectively obtained serial head orbitofrontal circumference measurements of: a) 48 sibling pairs in which one (n=28) or both (n=20) sibs were affected by an autism spectrum disorder (ASD); and b) 85 control male sibling pairs. RESULTS: Rate of HG of ASD subjects was slightly accelerated compared to controls, but the magnitude of difference was below the limit of reliability of standard measurement methods. Sibling intra class correlation for rate of HG was highly statistically significant; the magnitude was significantly stronger among autism-affected families (ICC=.63) than among controls (ICC=.26), p<.01. CONCLUSION: Infant HG trajectory appears familial-possibly endophenotypic-but was not a reliable marker of autism risk among siblings of ASD probands in this sample. En ligne : http://dx.doi.org/10.1007/s11689-009-9036-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Risk factors for preschool depression: the mediating role of early stressful life events / Joan L. LUBY in Journal of Child Psychology and Psychiatry, 47-12 (December 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-12 (December 2006) . - p.1292–1298 Titre : Risk factors for preschool depression: the mediating role of early stressful life events Type de document : texte imprimé Auteurs : Joan L. LUBY, Auteur ; Andy C. BELDEN, Auteur ; Edward SPITZNAGEL, Auteur Année de publication : 2007 Article en page(s) : p.1292–1298 Langues : Anglais (eng) Mots-clés : Development family-history parent-child-relationships psychosocial-risk preschool-depression Index. décimale : PER Périodiques Résumé : Background: Family history of mood disorders and stressful life events are both established risk factors for childhood depression. However, the role of mediators in risk trajectories, which are potential targets for intervention, remains understudied. To date, there have been no investigations of mediating relationships between risk factors and very early onset depression, a developmental period during which intervention may be more effective. The current study used regression analyses to examine the relationships between family history of mood disorders and stressful life events as risk factors for depression in a preschool sample. Method: Preschoolers 3.0 to 5.6 years of age participated in a comprehensive mental health assessment. Caregivers were interviewed about their children using a structured diagnostic measure to derive DSM-IV major depressive disorder (MDD) diagnoses and dimensional depression severity scores. Family history of psychiatric disorders and preschoolers' stressful life events was obtained. Results: Both family history and stressful life events predicted depression severity scores 6 months later. Analyses examining the influence of family history of mood disorders and stressful life events on preschoolers' depression severity demonstrated that stressful life events mediated the relationship between family history and preschoolers' depression. Conclusions: Findings outline the key role of exposure to early stressful life events as a mediator of familial mood disorder risk in preschool onset depression. This finding in a preschool sample provides support for the hypothesis that psychosocial factors may have increased importance as mediators of risk in younger age groups. Findings suggest that psychosocial factors should be considered key targets for early intervention in depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01672.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=819 [article] Risk factors for preschool depression: the mediating role of early stressful life events [texte imprimé] / Joan L. LUBY, Auteur ; Andy C. BELDEN, Auteur ; Edward SPITZNAGEL, Auteur . - 2007 . - p.1292–1298. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-12 (December 2006) . - p.1292–1298 Mots-clés : Development family-history parent-child-relationships psychosocial-risk preschool-depression Index. décimale : PER Périodiques Résumé : Background: Family history of mood disorders and stressful life events are both established risk factors for childhood depression. However, the role of mediators in risk trajectories, which are potential targets for intervention, remains understudied. To date, there have been no investigations of mediating relationships between risk factors and very early onset depression, a developmental period during which intervention may be more effective. The current study used regression analyses to examine the relationships between family history of mood disorders and stressful life events as risk factors for depression in a preschool sample. Method: Preschoolers 3.0 to 5.6 years of age participated in a comprehensive mental health assessment. Caregivers were interviewed about their children using a structured diagnostic measure to derive DSM-IV major depressive disorder (MDD) diagnoses and dimensional depression severity scores. Family history of psychiatric disorders and preschoolers' stressful life events was obtained. Results: Both family history and stressful life events predicted depression severity scores 6 months later. Analyses examining the influence of family history of mood disorders and stressful life events on preschoolers' depression severity demonstrated that stressful life events mediated the relationship between family history and preschoolers' depression. Conclusions: Findings outline the key role of exposure to early stressful life events as a mediator of familial mood disorder risk in preschool onset depression. This finding in a preschool sample provides support for the hypothesis that psychosocial factors may have increased importance as mediators of risk in younger age groups. Findings suggest that psychosocial factors should be considered key targets for early intervention in depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01672.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=819

Shame and guilt in preschool depression: evidence for elevations in self-conscious emotions in depression as early as age 3 / Joan L. LUBY in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1156-1166 Titre : Shame and guilt in preschool depression: evidence for elevations in self-conscious emotions in depression as early as age 3 Type de document : texte imprimé Auteurs : Joan L. LUBY, Auteur ; Andy C. BELDEN, Auteur ; Edward SPITZNAGEL, Auteur ; Robin D. ALLEN, Auteur ; Jill P. SULLIVAN, Auteur ; Amber MCCADNEY, Auteur Année de publication : 2009 Article en page(s) : p.1156-1166 Langues : Anglais (eng) Mots-clés : Guilt shame depression young-children preschoolers Index. décimale : PER Périodiques Résumé : Background: Empirical findings from two divergent bodies of literature illustrate that depression can arise in the preschool period and that the complex self-conscious emotions of guilt and shame may develop normatively as early as age 3. Despite these related findings, few studies have examined whether the emotions of shame and guilt are salient in early childhood depression. This is important to further understand the emotional characteristics of preschool depression. Based on the hypothesis that preschool depression would be uniquely associated with higher levels of shame and maladaptive guilt, these emotions were investigated in a sample that included depressed, anxious, and disruptive disordered preschoolers as well as healthy peers using multiple methods. Method: Structured psychiatric diagnoses were derived in a sample of N = 305 preschoolers ascertained from community sites. Preschoolers' tendency to experience shame and guilt were explored using a story stem completion task coded by raters blind to symptoms and diagnosis of the subjects. Guilt experience and reparation behaviors were also measured using parent report. Results: Based on preschooler's emotion themes during the narrative tasks, gender, age, and depression severity predicted unique and significant portions of the variance in preschoolers' expressions of shame. Parent report measures revealed that increasing depression severity was associated with children's more frequent experiences of guilt feelings and less frequent attempts at guilt reparation (maladaptive guilt). Conclusions: Findings demonstrated that high levels of shame and maladaptive guilt were related to preschool onset depression when using observational measures of children's internal representations of their self-conscious emotions as well as parent report. These findings demonstrate continuity of these core emotions of depression as early as age 3. These findings suggest that guilt and shame should be explored in clinical assessments of young children and may be an important focus for future studies of the developmental psychopathology of depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02077.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=829 [article] Shame and guilt in preschool depression: evidence for elevations in self-conscious emotions in depression as early as age 3 [texte imprimé] / Joan L. LUBY, Auteur ; Andy C. BELDEN, Auteur ; Edward SPITZNAGEL, Auteur ; Robin D. ALLEN, Auteur ; Jill P. SULLIVAN, Auteur ; Amber MCCADNEY, Auteur . - 2009 . - p.1156-1166. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1156-1166 Mots-clés : Guilt shame depression young-children preschoolers Index. décimale : PER Périodiques Résumé : Background: Empirical findings from two divergent bodies of literature illustrate that depression can arise in the preschool period and that the complex self-conscious emotions of guilt and shame may develop normatively as early as age 3. Despite these related findings, few studies have examined whether the emotions of shame and guilt are salient in early childhood depression. This is important to further understand the emotional characteristics of preschool depression. Based on the hypothesis that preschool depression would be uniquely associated with higher levels of shame and maladaptive guilt, these emotions were investigated in a sample that included depressed, anxious, and disruptive disordered preschoolers as well as healthy peers using multiple methods. Method: Structured psychiatric diagnoses were derived in a sample of N = 305 preschoolers ascertained from community sites. Preschoolers' tendency to experience shame and guilt were explored using a story stem completion task coded by raters blind to symptoms and diagnosis of the subjects. Guilt experience and reparation behaviors were also measured using parent report. Results: Based on preschooler's emotion themes during the narrative tasks, gender, age, and depression severity predicted unique and significant portions of the variance in preschoolers' expressions of shame. Parent report measures revealed that increasing depression severity was associated with children's more frequent experiences of guilt feelings and less frequent attempts at guilt reparation (maladaptive guilt). Conclusions: Findings demonstrated that high levels of shame and maladaptive guilt were related to preschool onset depression when using observational measures of children's internal representations of their self-conscious emotions as well as parent report. These findings demonstrate continuity of these core emotions of depression as early as age 3. These findings suggest that guilt and shame should be explored in clinical assessments of young children and may be an important focus for future studies of the developmental psychopathology of depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02077.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=829

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