[article]
| Titre : |
Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Marco PAGANI, Auteur ; Irina MANOUILENKO, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Dario SALMASO, Auteur ; Robert HATHERLY, Auteur ; Fredrik BROLIN, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p.313-318 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
High functioning autism PET/CT [1-11C]butanol Cerebral blood flow |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal “social” brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-11C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-011-1240-y |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 |
in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.313-318
[article] Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ [Texte imprimé et/ou numérique] / Marco PAGANI, Auteur ; Irina MANOUILENKO, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Dario SALMASO, Auteur ; Robert HATHERLY, Auteur ; Fredrik BROLIN, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - 2012 . - p.313-318. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.313-318
| Mots-clés : |
High functioning autism PET/CT [1-11C]butanol Cerebral blood flow |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal “social” brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-11C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-011-1240-y |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 |
|  |
Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ in Journal of Autism and Developmental Disorders, 42-2 (February 2012)
