Brain basis of early parent–infant interactions: psychology, physiology, and in vivo functional neuroimaging studies / James E. SWAIN in Journal of Child Psychology and Psychiatry, 48-3/4 (March/April 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-3/4 (March/April 2007) . - p.262–287 Titre : Brain basis of early parent–infant interactions: psychology, physiology, and in vivo functional neuroimaging studies Type de document : Texte imprimé et/ou numérique Auteurs : James E. SWAIN, Auteur ; Jeffrey P. LORBERBAUM, Auteur ; Samet KOSE, Auteur ; Lane STRATHEARN, Auteur Année de publication : 2007 Article en page(s) : p.262–287 Langues : Anglais (eng) Mots-clés : Attachment brain-imaging parent–child-interaction parent–child-relationships parenting neuropsychology neurobiology neurophysiologychild-development Index. décimale : PER Périodiques Résumé : Parenting behavior critically shapes human infants’ current and future behavior. The parent–infant relationship provides infants with their first social experiences, forming templates of what they can expect from others and how to best meet others’ expectations. In this review, we focus on the neurobiology of parenting behavior, including our own functional magnetic resonance imaging (fMRI) brain imaging experiments of parents. We begin with a discussion of background, perspectives and caveats for considering the neurobiology of parent–infant relationships. Then, we discuss aspects of the psychology of parenting that are significantly motivating some of the more basic neuroscience research. Following that, we discuss some of the neurohormones that are important for the regulation of social bonding, and the dysregulation of parenting with cocaine abuse. Then, we review the brain circuitry underlying parenting, proceeding from relevant rodent and nonhuman primate research to human work. Finally, we focus on a study-by-study review of functional neuroimaging studies in humans. Taken together, this research suggests that networks of highly conserved hypothalamic–midbrain–limbic–paralimbic–cortical circuits act in concert to support aspects of parent response to infants, including the emotion, attention, motivation, empathy, decision-making and other thinking that are required to navigate the complexities of parenting. Specifically, infant stimuli activate basal forebrain regions, which regulate brain circuits that handle specific nurturing and caregiving responses and activate the brain's more general circuitry for handling emotions, motivation, attention, and empathy – all of which are crucial for effective parenting. We argue that an integrated understanding of the brain basis of parenting has profound implications for mental health. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01731.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=949 [article] Brain basis of early parent–infant interactions: psychology, physiology, and in vivo functional neuroimaging studies [Texte imprimé et/ou numérique] / James E. SWAIN, Auteur ; Jeffrey P. LORBERBAUM, Auteur ; Samet KOSE, Auteur ; Lane STRATHEARN, Auteur . - 2007 . - p.262–287. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-3/4 (March/April 2007) . - p.262–287 Mots-clés : Attachment brain-imaging parent–child-interaction parent–child-relationships parenting neuropsychology neurobiology neurophysiologychild-development Index. décimale : PER Périodiques Résumé : Parenting behavior critically shapes human infants’ current and future behavior. The parent–infant relationship provides infants with their first social experiences, forming templates of what they can expect from others and how to best meet others’ expectations. In this review, we focus on the neurobiology of parenting behavior, including our own functional magnetic resonance imaging (fMRI) brain imaging experiments of parents. We begin with a discussion of background, perspectives and caveats for considering the neurobiology of parent–infant relationships. Then, we discuss aspects of the psychology of parenting that are significantly motivating some of the more basic neuroscience research. Following that, we discuss some of the neurohormones that are important for the regulation of social bonding, and the dysregulation of parenting with cocaine abuse. Then, we review the brain circuitry underlying parenting, proceeding from relevant rodent and nonhuman primate research to human work. Finally, we focus on a study-by-study review of functional neuroimaging studies in humans. Taken together, this research suggests that networks of highly conserved hypothalamic–midbrain–limbic–paralimbic–cortical circuits act in concert to support aspects of parent response to infants, including the emotion, attention, motivation, empathy, decision-making and other thinking that are required to navigate the complexities of parenting. Specifically, infant stimuli activate basal forebrain regions, which regulate brain circuits that handle specific nurturing and caregiving responses and activate the brain's more general circuitry for handling emotions, motivation, attention, and empathy – all of which are crucial for effective parenting. We argue that an integrated understanding of the brain basis of parenting has profound implications for mental health. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01731.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=949

Visual systemizing preference in children with autism: A randomized controlled trial of intranasal oxytocin / Lane STRATHEARN in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.511-521 Titre : Visual systemizing preference in children with autism: A randomized controlled trial of intranasal oxytocin Type de document : Texte imprimé et/ou numérique Auteurs : Lane STRATHEARN, Auteur ; Sohye KIM, Auteur ; D. Anthony BASTIAN, Auteur ; Jennifer JUNG, Auteur ; Udita IYENGAR, Auteur ; Sheila MARTINEZ, Auteur ; Robin P. GOIN-KOCHEL, Auteur ; Peter FONAGY, Auteur Article en page(s) : p.511-521 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several studies have suggested that the neuropeptide oxytocin may enhance aspects of social communication in autism. Little is known, however, about its effects on nonsocial manifestations, such as restricted interests and repetitive behaviors. In the empathizing–systemizing theory of autism, social deficits are described along the continuum of empathizing ability, whereas nonsocial aspects are characterized in terms of an increased preference for patterned or rule-based systems, called systemizing. We therefore developed an automated eye-tracking task to test whether children and adolescents with autism spectrum disorder (ASD) compared to matched controls display a visual preference for more highly organized and structured (systemized) real-life images. Then, as part of a randomized, double-blind, placebo-controlled crossover study, we examined the effect of intranasal oxytocin on systemizing preferences in 16 male children with ASD, compared with 16 matched controls. Participants viewed 14 slides, each containing four related pictures (e.g., of people, animals, scenes, or objects) that differed primarily on the degree of systemizing. Visual systemizing preference was defined in terms of the fixation time and count for each image. Unlike control subjects who showed no gaze preference, individuals with ASD preferred to fixate on more highly systemized pictures. Intranasal oxytocin eliminated this preference in ASD participants, who now showed a similar response to control subjects on placebo. In contrast, control participants increased their visual preference for more systemized images after receiving oxytocin versus placebo. These results suggest that, in addition to its effects on social communication, oxytocin may play a role in some of the nonsocial manifestations of autism. En ligne : http://dx.doi.org/10.1017/S0954579417001018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Visual systemizing preference in children with autism: A randomized controlled trial of intranasal oxytocin [Texte imprimé et/ou numérique] / Lane STRATHEARN, Auteur ; Sohye KIM, Auteur ; D. Anthony BASTIAN, Auteur ; Jennifer JUNG, Auteur ; Udita IYENGAR, Auteur ; Sheila MARTINEZ, Auteur ; Robin P. GOIN-KOCHEL, Auteur ; Peter FONAGY, Auteur . - p.511-521. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.511-521 Index. décimale : PER Périodiques Résumé : Several studies have suggested that the neuropeptide oxytocin may enhance aspects of social communication in autism. Little is known, however, about its effects on nonsocial manifestations, such as restricted interests and repetitive behaviors. In the empathizing–systemizing theory of autism, social deficits are described along the continuum of empathizing ability, whereas nonsocial aspects are characterized in terms of an increased preference for patterned or rule-based systems, called systemizing. We therefore developed an automated eye-tracking task to test whether children and adolescents with autism spectrum disorder (ASD) compared to matched controls display a visual preference for more highly organized and structured (systemized) real-life images. Then, as part of a randomized, double-blind, placebo-controlled crossover study, we examined the effect of intranasal oxytocin on systemizing preferences in 16 male children with ASD, compared with 16 matched controls. Participants viewed 14 slides, each containing four related pictures (e.g., of people, animals, scenes, or objects) that differed primarily on the degree of systemizing. Visual systemizing preference was defined in terms of the fixation time and count for each image. Unlike control subjects who showed no gaze preference, individuals with ASD preferred to fixate on more highly systemized pictures. Intranasal oxytocin eliminated this preference in ASD participants, who now showed a similar response to control subjects on placebo. In contrast, control participants increased their visual preference for more systemized images after receiving oxytocin versus placebo. These results suggest that, in addition to its effects on social communication, oxytocin may play a role in some of the nonsocial manifestations of autism. En ligne : http://dx.doi.org/10.1017/S0954579417001018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

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