[article] 
inDevelopment and Psychopathology > 24-3 (August 2012) . - p.941-51

Titre :	Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur ; Steven M. KOGAN, Auteur ; Ronald L. SIMONS, Auteur ; Michael WINDLE, Auteur ; Robert A. PHILIBERT, Auteur
Année de publication :	2012
Article en page(s) :	p.941-51
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	This study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who reported high life stress and carried the 7 + R allele evinced the largest increases in two proximal risk factors for drug use: affiliations with drug-using companions and drug use vulnerability cognitions. Furthermore, when the Gene × Environment interaction effects on the increases in affiliations with drug-using companions and vulnerability cognitions were entered into the model forecasting drug use, the Life Stress × DRD4 Status interaction on drug use became nonsignificant in the presence of the risk mechanisms. This finding provides an example of “second generation” Gene × Environment interaction research in which the interaction's effects on proximal risk mechanisms account for its effects on outcomes.
En ligne :	http://dx.doi.org/10.1017/S0954579412000466
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

[article] Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur ; Steven M. KOGAN, Auteur ; Ronald L. SIMONS, Auteur ; Michael WINDLE, Auteur ; Robert A. PHILIBERT, Auteur . - 2012 . - p.941-51.
Langues : Anglais (eng)
in Development and Psychopathology > 24-3 (August 2012) . - p.941-51

Index. décimale :	PER Périodiques
Résumé :	This study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who reported high life stress and carried the 7 + R allele evinced the largest increases in two proximal risk factors for drug use: affiliations with drug-using companions and drug use vulnerability cognitions. Furthermore, when the Gene × Environment interaction effects on the increases in affiliations with drug-using companions and vulnerability cognitions were entered into the model forecasting drug use, the Life Stress × DRD4 Status interaction on drug use became nonsignificant in the presence of the risk mechanisms. This finding provides an example of “second generation” Gene × Environment interaction research in which the interaction's effects on proximal risk mechanisms account for its effects on outcomes.
En ligne :	http://dx.doi.org/10.1017/S0954579412000466
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178