[article] 
inJournal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1729-1737

Titre :	Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur
Année de publication :	2012
Article en page(s) :	p.1729-1737
Langues :	Anglais (eng)
Mots-clés :	Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule
Index. décimale :	PER Périodiques
Résumé :	Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population.
En ligne :	http://dx.doi.org/10.1007/s10803-011-1418-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

[article] Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes [Texte imprimé et/ou numérique] / Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur . - 2012 . - p.1729-1737.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1729-1737

Mots-clés :	Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule
Index. décimale :	PER Périodiques
Résumé :	Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population.
En ligne :	http://dx.doi.org/10.1007/s10803-011-1418-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178