[article]
| Titre : |
Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Haitham M. HASHIM, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Doaa MOHAMMED, Auteur ; Rehab KARAM, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p.199–204 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Transforming growth factor-β1 IL-23 IL-17 |
| Index. décimale : |
PER Périodiques |
| Résumé : |
It has been recently shown that dysregulation of transforming growth factor-β1 (TGF-β1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-β 1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-β1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6–12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-β1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P < 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-β1 with IL-17 in children with ASD. There was a negative correlation between TGF-β1, IL-23 and IL-17 with the severity of autism (P < 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. |
| En ligne : |
http://dx.doi.org/10.1016/j.rasd.2012.08.007 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 |
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.199–204
[article] Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children [Texte imprimé et/ou numérique] / Haitham M. HASHIM, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Doaa MOHAMMED, Auteur ; Rehab KARAM, Auteur . - 2013 . - p.199–204. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.199–204
| Mots-clés : |
Autism Transforming growth factor-β1 IL-23 IL-17 |
| Index. décimale : |
PER Périodiques |
| Résumé : |
It has been recently shown that dysregulation of transforming growth factor-β1 (TGF-β1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-β 1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-β1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6–12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-β1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P < 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-β1 with IL-17 in children with ASD. There was a negative correlation between TGF-β1, IL-23 and IL-17 with the severity of autism (P < 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. |
| En ligne : |
http://dx.doi.org/10.1016/j.rasd.2012.08.007 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 |
|  |
Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children in Research in Autism Spectrum Disorders, 7-1 (January 2013)
