| Titre : |
The Environment in Autism Spectrum Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Kristen LYALL, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur |
| Année de publication : |
2013 |
| Importance : |
p.203-214 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
A growing body of literature has begun to uncover associations between autism and a range of environmental agents. Several maternal infections, certain medications, and exposures to air pollution in the prenatal period have been linked to autism spectrum disorders (ASD) with replication by at least a second research group. Factors with emerging evidence include maternal nutritional status, smoking, and use of pesticides. These exposures may act directly on basic processes in neurodevelopment, such as molecular signaling, epigenetic imprinting, cell migration, and synaptogenesis, while indirect effects through immune dysregulation or endocrine disruption may also be relevant. Reports on season of birth/conception and autism risk are consistent with infections, nutrients, and pesticides. It is recommended that key strategies rely on large epidemiological studies with standardized confirmation of diagnoses and collection of biospecimens and environmental samples. These in turn can help to (1) determine critical time periods when susceptibility to specific environmental factors is enhanced; (2) uncover gene—environment interactions that elucidate mechanisms; and (3) identify early biomarkers that will enable intervention to be introduced at the youngest possible ages. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
The Environment in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - 2013 . - p.203-214. Langues : Anglais ( eng)
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
A growing body of literature has begun to uncover associations between autism and a range of environmental agents. Several maternal infections, certain medications, and exposures to air pollution in the prenatal period have been linked to autism spectrum disorders (ASD) with replication by at least a second research group. Factors with emerging evidence include maternal nutritional status, smoking, and use of pesticides. These exposures may act directly on basic processes in neurodevelopment, such as molecular signaling, epigenetic imprinting, cell migration, and synaptogenesis, while indirect effects through immune dysregulation or endocrine disruption may also be relevant. Reports on season of birth/conception and autism risk are consistent with infections, nutrients, and pesticides. It is recommended that key strategies rely on large epidemiological studies with standardized confirmation of diagnoses and collection of biospecimens and environmental samples. These in turn can help to (1) determine critical time periods when susceptibility to specific environmental factors is enhanced; (2) uncover gene—environment interactions that elucidate mechanisms; and (3) identify early biomarkers that will enable intervention to be introduced at the youngest possible ages. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
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The Environment in Autism Spectrum Disorders