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Auteur Rebecca J. SCHMIDT |
Documents disponibles écrits par cet auteur (23)



Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children / Ashley Y. SONG in Autism Research, 15-12 (December 2022)
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Titre : Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children Type de document : Texte imprimé et/ou numérique Auteurs : Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur Article en page(s) : p.2359-2370 Langues : Anglais (eng) Mots-clés : Child Male Pregnancy Female Humans Autism Spectrum Disorder/epidemiology/genetics Prospective Studies Parents Cognition Biological Products Epigenesis, Genetic DNA methylation age acceleration autism spectrum disorder autism-related traits biologic age epigenetic age parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-12 (December 2022) . - p.2359-2370[article] Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children [Texte imprimé et/ou numérique] / Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur . - p.2359-2370.
Langues : Anglais (eng)
in Autism Research > 15-12 (December 2022) . - p.2359-2370
Mots-clés : Child Male Pregnancy Female Humans Autism Spectrum Disorder/epidemiology/genetics Prospective Studies Parents Cognition Biological Products Epigenesis, Genetic DNA methylation age acceleration autism spectrum disorder autism-related traits biologic age epigenetic age parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program / Aisha S. DICKERSON ; Tingju HSU ; Aseel AL-JADIRI ; Carlos A. CAMARGO ; Julie B. SCHWEITZER ; Coral L. SHUSTER ; Margaret R. KARAGAS ; Juliette C. MADAN ; Bibiana RESTREPO ; Rebecca J. SCHMIDT ; Claudia LUGO-CANDELAS ; Jenae NEIDERHISER ; Sheela SATHYANARAYANA ; Anne L. DUNLOP ; Patricia A. BRENNAN ; program collaborators for Environmental influences on Child Health OUTCOMES in Autism Research, 17-8 (August 2024)
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Titre : Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program Type de document : Texte imprimé et/ou numérique Auteurs : Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1651-1664 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533
in Autism Research > 17-8 (August 2024) . - p.1651-1664[article] Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program [Texte imprimé et/ou numérique] / Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1651-1664.
Langues : Anglais (eng)
in Autism Research > 17-8 (August 2024) . - p.1651-1664
Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment / Yihui ZHU in Autism Research, 14-1 (January 2021)
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Titre : Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment Type de document : Texte imprimé et/ou numérique Auteurs : Yihui ZHU, Auteur ; Charles E. MORDAUNT, Auteur ; Blythe DURBIN-JOHNSON, Auteur ; Marie A. CAUDILL, Auteur ; Olga V. MALYSHEVA, Auteur ; Joshua W. MILLER, Auteur ; Ralph GREEN, Auteur ; S. Jill JAMES, Auteur ; Stepan B. MELNYK, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Janine M. LASALLE, Auteur Article en page(s) : p.11-28 Langues : Anglais (eng) Mots-clés : autism spectrum disorder maternal blood neurodevelopment nutrition one-carbon metabolites prenatal transcriptome Index. décimale : PER Périodiques Résumé : The prenatal period is a critical window for the development of autism spectrum disorder (ASD). The relationship between prenatal nutrients and gestational gene expression in mothers of children later diagnosed with ASD or non-typical development (Non-TD) is poorly understood. Maternal blood collected prospectively during pregnancy provides insights into the effects of nutrition, particularly one-carbon metabolites, on gene pathways and neurodevelopment. Genome-wide transcriptomes were measured with microarrays in 300 maternal blood samples in Markers of Autism Risk in Babies-Learning Early Signs. Sixteen different one-carbon metabolites, including folic acid, betaine, 5'-methyltretrahydrofolate (5-MeTHF), and dimethylglycine (DMG) were measured. Differential expression analysis and weighted gene correlation network analysis (WGCNA) were used to compare gene expression between children later diagnosed as typical development (TD), Non-TD and ASD, and to one-carbon metabolites. Using differential gene expression analysis, six transcripts (TGR-AS1, SQSTM1, HLA-C, and RFESD) were associated with child outcomes (ASD, Non-TD, and TD) with genome-wide significance. Genes nominally differentially expressed between ASD and TD significantly overlapped with seven high confidence ASD genes. WGCNA identified co-expressed gene modules significantly correlated with 5-MeTHF, folic acid, DMG, and betaine. A module enriched in DNA methylation functions showed a suggestive protective association with folic acid/5-MeTHF concentrations and ASD risk. Maternal plasma betaine and DMG concentrations were associated with a block of co-expressed genes enriched for adaptive immune, histone modification, and RNA processing functions. These results suggest that the prenatal maternal blood transcriptome is a sensitive indicator of gestational one-carbon metabolite status and changes relevant to children's later neurodevelopmental outcomes. LAY SUMMARY: Pregnancy is a time when maternal nutrition could interact with genetic risk for autism spectrum disorder. Blood samples collected during pregnancy from mothers who had a prior child with autism were examined for gene expression and nutrient metabolites, then compared to the diagnosis of the child at age three. Expression differences in gene pathways related to the immune system and gene regulation were observed for pregnancies of children with autism and non-typical neurodevelopment and were associated with maternal nutrients. En ligne : http://dx.doi.org/10.1002/aur.2428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-1 (January 2021) . - p.11-28[article] Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment [Texte imprimé et/ou numérique] / Yihui ZHU, Auteur ; Charles E. MORDAUNT, Auteur ; Blythe DURBIN-JOHNSON, Auteur ; Marie A. CAUDILL, Auteur ; Olga V. MALYSHEVA, Auteur ; Joshua W. MILLER, Auteur ; Ralph GREEN, Auteur ; S. Jill JAMES, Auteur ; Stepan B. MELNYK, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Janine M. LASALLE, Auteur . - p.11-28.
Langues : Anglais (eng)
in Autism Research > 14-1 (January 2021) . - p.11-28
Mots-clés : autism spectrum disorder maternal blood neurodevelopment nutrition one-carbon metabolites prenatal transcriptome Index. décimale : PER Périodiques Résumé : The prenatal period is a critical window for the development of autism spectrum disorder (ASD). The relationship between prenatal nutrients and gestational gene expression in mothers of children later diagnosed with ASD or non-typical development (Non-TD) is poorly understood. Maternal blood collected prospectively during pregnancy provides insights into the effects of nutrition, particularly one-carbon metabolites, on gene pathways and neurodevelopment. Genome-wide transcriptomes were measured with microarrays in 300 maternal blood samples in Markers of Autism Risk in Babies-Learning Early Signs. Sixteen different one-carbon metabolites, including folic acid, betaine, 5'-methyltretrahydrofolate (5-MeTHF), and dimethylglycine (DMG) were measured. Differential expression analysis and weighted gene correlation network analysis (WGCNA) were used to compare gene expression between children later diagnosed as typical development (TD), Non-TD and ASD, and to one-carbon metabolites. Using differential gene expression analysis, six transcripts (TGR-AS1, SQSTM1, HLA-C, and RFESD) were associated with child outcomes (ASD, Non-TD, and TD) with genome-wide significance. Genes nominally differentially expressed between ASD and TD significantly overlapped with seven high confidence ASD genes. WGCNA identified co-expressed gene modules significantly correlated with 5-MeTHF, folic acid, DMG, and betaine. A module enriched in DNA methylation functions showed a suggestive protective association with folic acid/5-MeTHF concentrations and ASD risk. Maternal plasma betaine and DMG concentrations were associated with a block of co-expressed genes enriched for adaptive immune, histone modification, and RNA processing functions. These results suggest that the prenatal maternal blood transcriptome is a sensitive indicator of gestational one-carbon metabolite status and changes relevant to children's later neurodevelopmental outcomes. LAY SUMMARY: Pregnancy is a time when maternal nutrition could interact with genetic risk for autism spectrum disorder. Blood samples collected during pregnancy from mothers who had a prior child with autism were examined for gene expression and nutrient metabolites, then compared to the diagnosis of the child at age three. Expression differences in gene pathways related to the immune system and gene regulation were observed for pregnancies of children with autism and non-typical neurodevelopment and were associated with maternal nutrients. En ligne : http://dx.doi.org/10.1002/aur.2428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 Inattention and hyperactivity in association with autism spectrum disorders in the CHARGE study / Kristen LYALL in Research in Autism Spectrum Disorders, 35 (March 2017)
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Titre : Inattention and hyperactivity in association with autism spectrum disorders in the CHARGE study Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Julie B. SCHWEITZER, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Marjorie SOLOMON, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Mots-clés : ASD ADHD Inattention Comorbidity Adaptive functioning Index. décimale : PER Périodiques Résumé : Attention deficits in young children with autism spectrum disorder (ASD) are not well understood. This study sought to determine: 1) the prevalence of ADHD symptoms in young children with ASD, typical development (TD), and developmental delay (DD) and 2) the association between ADHD symptoms and cognitive and behavioral functioning in children with ASD. Method ADHD symptoms, defined according to Aberrant Behavior Checklist (ABC) hyperactivity subscale scores, were compared across children aged 2–5 from a large case-control study with ASD (n = 548), TD (n = 423), and DD (n = 180). Inattention and hyperactivity items within this subscale were also explored. Within the ASD group, linear and logistic regression were used to examine how ADHD symptoms were associated with cognition as assessed by the Mullen Scales of Early Learning and adaptive functioning as assessed by the Vineland Adaptive Behavior Scales. Results Mean hyperactivity subscale scores were lowest in children with TD (mean = 3.19), higher in children with DD (12.3), and highest in children with ASD (18.2; between-group p < 0.001). Among children with ASD, significant associations were observed with higher ADHD symptoms and poorer adaptive and cognitive functioning (adjusted beta for hyperactivity score in association with: Vineland composite = ?5.63, p = 0.0005; Mullen visual reception scale = ?2.94, p = 0.02; for the highest vs. lowest quartile of hyperactivity score, odds of lowest quintile of these scores was approximately doubled). Exploratory analyses highlighted associations with inattention-related items specifically. These results suggest ADHD symptoms may play a key role in the functioning of young children with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Research in Autism Spectrum Disorders > 35 (March 2017) . - p.1-12[article] Inattention and hyperactivity in association with autism spectrum disorders in the CHARGE study [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Julie B. SCHWEITZER, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Marjorie SOLOMON, Auteur . - p.1-12.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 35 (March 2017) . - p.1-12
Mots-clés : ASD ADHD Inattention Comorbidity Adaptive functioning Index. décimale : PER Périodiques Résumé : Attention deficits in young children with autism spectrum disorder (ASD) are not well understood. This study sought to determine: 1) the prevalence of ADHD symptoms in young children with ASD, typical development (TD), and developmental delay (DD) and 2) the association between ADHD symptoms and cognitive and behavioral functioning in children with ASD. Method ADHD symptoms, defined according to Aberrant Behavior Checklist (ABC) hyperactivity subscale scores, were compared across children aged 2–5 from a large case-control study with ASD (n = 548), TD (n = 423), and DD (n = 180). Inattention and hyperactivity items within this subscale were also explored. Within the ASD group, linear and logistic regression were used to examine how ADHD symptoms were associated with cognition as assessed by the Mullen Scales of Early Learning and adaptive functioning as assessed by the Vineland Adaptive Behavior Scales. Results Mean hyperactivity subscale scores were lowest in children with TD (mean = 3.19), higher in children with DD (12.3), and highest in children with ASD (18.2; between-group p < 0.001). Among children with ASD, significant associations were observed with higher ADHD symptoms and poorer adaptive and cognitive functioning (adjusted beta for hyperactivity score in association with: Vineland composite = ?5.63, p = 0.0005; Mullen visual reception scale = ?2.94, p = 0.02; for the highest vs. lowest quartile of hyperactivity score, odds of lowest quintile of these scores was approximately doubled). Exploratory analyses highlighted associations with inattention-related items specifically. These results suggest ADHD symptoms may play a key role in the functioning of young children with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder / J. GOODRICH AMANDA in Autism Research, 11-1 (January 2018)
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Titre : Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur Article en page(s) : p.69-80 Langues : Anglais (eng) Mots-clés : autism ASD folic acid air pollution prenatal exposure environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha?0.10) departures from expected interaction for NRP and NO2. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. Further study is needed to replicate these findings in larger sample sizes and to understand mechanisms of this potential relationship.. Autism Res 2018, 11: 69?80. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333
in Autism Research > 11-1 (January 2018) . - p.69-80[article] Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder [Texte imprimé et/ou numérique] / J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur . - p.69-80.
Langues : Anglais (eng)
in Autism Research > 11-1 (January 2018) . - p.69-80
Mots-clés : autism ASD folic acid air pollution prenatal exposure environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha?0.10) departures from expected interaction for NRP and NO2. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. Further study is needed to replicate these findings in larger sample sizes and to understand mechanisms of this potential relationship.. Autism Res 2018, 11: 69?80. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study / Lauren GRANILLO in Research in Autism Spectrum Disorders, 99 (November)
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PermalinkMaternal metabolic profile predicts high or low risk of an autism pregnancy outcome / Kathryn HOLLOWOOD in Research in Autism Spectrum Disorders, 56 (December 2018)
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PermalinkMaternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study / Yunru HUANG in Autism, 24-5 (July 2020)
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PermalinkMaternal preconception and prenatal stressful life events in association with child neurodevelopmental outcome in MARBLES: A high familial likelihood cohort / Daniel J. TANCREDI ; Rebecca J. SCHMIDT in Research in Autism Spectrum Disorders, 114 (June 2024)
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PermalinkMaternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts / Irva HERTZ-PICCIOTTO in Autism Research, 15-3 (March 2022)
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PermalinkA meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood / C. E. MORDAUNT in Molecular Autism, 10 (2019)
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PermalinkNeonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study / Rebecca J. SCHMIDT in Autism Research, 12-6 (June 2019)
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PermalinkPlacental methylome analysis from a prospective autism study / D. I. SCHROEDER in Molecular Autism, 7 (2016)
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PermalinkPrenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study / Emily E. JOYCE in Autism Research, 15-5 (May 2022)
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PermalinkPrenatal perceived stress and urinary cortisol as risk factors for ASD and non-typical developmental outcomes in the MARBLES study / Daniel J. TANCREDI ; Rebecca J. SCHMIDT in Research in Autism Spectrum Disorders, 114 (June 2024)
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