| Titre : |
The Amygdala in Autism Spectrum Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
John T. MORGAN, Auteur ; Christine W. NORDAHL, Auteur ; Cynthia M. SCHUMANN, Auteur |
| Année de publication : |
2013 |
| Importance : |
p.297-312 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
The amygdala plays a critical role in detecting and responding to biologically relevant environmental stimuli. It is also considered a major component of a network of brain regions often referred to as the ‘social brain’. Given the social abnormalities that are a hallmark of autism spectrum disorders (ASD), the amygdala has long been suspected to be aberrant in the disorder. Functional magnetic resonance imaging (MRI) studies reveal abnormalities in amygdala activation to social stimuli, such as emotional facial expressions. Structural MRI studies have shown that the amygdala undergoes an abnormal developmental trajectory including early overgrowth that may be primarily driven by a specific subgroup of individuals with ASD. Postmortem cellular studies reveal that abnormalities in the neuronal and glial composition of the amygdala likely underlie these functional and structural alterations. Interdisciplinary integration of an array of experimental approaches will hold the key to a full understanding of amygdala abnormality in ASD. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
The Amygdala in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / John T. MORGAN, Auteur ; Christine W. NORDAHL, Auteur ; Cynthia M. SCHUMANN, Auteur . - 2013 . - p.297-312. Langues : Anglais ( eng)
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
The amygdala plays a critical role in detecting and responding to biologically relevant environmental stimuli. It is also considered a major component of a network of brain regions often referred to as the ‘social brain’. Given the social abnormalities that are a hallmark of autism spectrum disorders (ASD), the amygdala has long been suspected to be aberrant in the disorder. Functional magnetic resonance imaging (MRI) studies reveal abnormalities in amygdala activation to social stimuli, such as emotional facial expressions. Structural MRI studies have shown that the amygdala undergoes an abnormal developmental trajectory including early overgrowth that may be primarily driven by a specific subgroup of individuals with ASD. Postmortem cellular studies reveal that abnormalities in the neuronal and glial composition of the amygdala likely underlie these functional and structural alterations. Interdisciplinary integration of an array of experimental approaches will hold the key to a full understanding of amygdala abnormality in ASD. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
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The Amygdala in Autism Spectrum Disorders