Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism / Matteo PARDINI in Journal of Autism and Developmental Disorders, 42-4 (April 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.585-592 Titre : Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Matteo PARDINI, Auteur ; Maurizio ELIA, Auteur ; Francesco GARACI, Auteur ; Silvia GUIDA, Auteur ; Filadelfo CONIGLIONE, Auteur ; Frank KRUEGER, Auteur ; Francesca BENASSI, Auteur ; Leonardo EMBERTI GIALLORETI, Auteur Année de publication : 2012 Article en page(s) : p.585-592 Langues : Anglais (eng) Mots-clés : Diffusion Tensor Imaging  Autism  Uncinate fasciculus  Cognitive therapy  Long-term rehabilitation Index. décimale : PER Périodiques Résumé : Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome. En ligne : http://dx.doi.org/10.1007/s10803-011-1281-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism [Texte imprimé et/ou numérique] / Matteo PARDINI, Auteur ; Maurizio ELIA, Auteur ; Francesco GARACI, Auteur ; Silvia GUIDA, Auteur ; Filadelfo CONIGLIONE, Auteur ; Frank KRUEGER, Auteur ; Francesca BENASSI, Auteur ; Leonardo EMBERTI GIALLORETI, Auteur . - 2012 . - p.585-592. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.585-592 Mots-clés : Diffusion Tensor Imaging  Autism  Uncinate fasciculus  Cognitive therapy  Long-term rehabilitation Index. décimale : PER Périodiques Résumé : Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome. En ligne : http://dx.doi.org/10.1007/s10803-011-1281-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

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