[article]
| Titre : |
Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p.212-220 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
animal models behavioral analysis of animal models??animal models genetics gamma-aminobutyric acid neurochemistry |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1280 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 |
in Autism Research > 6-3 (June 2013) . - p.212-220
[article] Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2013 . - p.212-220. Langues : Anglais ( eng) in Autism Research > 6-3 (June 2013) . - p.212-220
| Mots-clés : |
animal models behavioral analysis of animal models??animal models genetics gamma-aminobutyric acid neurochemistry |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1280 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 |
|
Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical in Autism Research, 6-3 (June 2013)
