Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression / Brandon E. GIBB in Journal of Clinical Child & Adolescent Psychology, 38-3 (May 2009)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 38-3 (May 2009) . - p.415-426 Titre : Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression Type de document : Texte imprimé et/ou numérique Auteurs : Brandon E. GIBB, Auteur ; Jessica S. BENAS, Auteur ; Marie GRASSIA, Auteur ; John E. MCGEARY, Auteur Année de publication : 2009 Article en page(s) : p.415-426 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or LG allele than among those homozygous for the LA allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR attentional bias mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLR S or LG allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression. En ligne : http://dx.doi.org/10.1080/15374410902851705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=757 [article] Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression [Texte imprimé et/ou numérique] / Brandon E. GIBB, Auteur ; Jessica S. BENAS, Auteur ; Marie GRASSIA, Auteur ; John E. MCGEARY, Auteur . - 2009 . - p.415-426. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 38-3 (May 2009) . - p.415-426 Index. décimale : PER Périodiques Résumé : In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or LG allele than among those homozygous for the LA allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR attentional bias mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLR S or LG allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression. En ligne : http://dx.doi.org/10.1080/15374410902851705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=757

Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings / Max OWENS in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.385-397 Titre : Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings Type de document : Texte imprimé et/ou numérique Auteurs : Max OWENS, Auteur ; Ashley J. HARRISON, Auteur ; Katie L. BURKHOUSE, Auteur ; John E. MCGEARY, Auteur ; Valerie S. KNOPIK, Auteur ; Rohan H. C. PALMER, Auteur ; Brandon E. GIBB, Auteur Article en page(s) : p.385-397 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Information-processing biases may contribute to the intergenerational transmission of depression. There is growing evidence that children of depressed mothers exhibit attentional biases for sad faces. However, findings are mixed as to whether this bias reflects preferential attention toward, versus attentional avoidance of, sad faces, suggesting the presence of unmeasured moderators. To address these mixed findings, we focused on the potential moderating role of genes associated with hypothalamic–pituitary–adrenal axis reactivity. Participants included children (8–14 years old) of mothers with (n = 81) and without (n = 81) a history of depression. Eye movements were recorded while children passively viewed arrays of angry, happy, sad, and neutral faces. DNA was obtained from buccal cells. Children of depressed mothers exhibited more sustained attention to sad faces than did children of nondepressed mothers. However, it is important that this relation was moderated by children's genotype. Specifically, children of depressed mothers who carried reactive genotypes across the corticotropin-releasing hormone type 1 receptor (CHRH1) TAT haplotype and FK506 binding protein 5 (FKBP5) rs1360780 (but not the solute carrier family C6 member 4 [SLC6A4] of the serotonin transporter linked polymorphic region [5-HTTLPR]) exhibited less sustained attention to sad faces and more sustained attention to happy faces. These findings highlight the role played by specific genetic influences and suggest that previous mixed findings may have been due to genetic heterogeneity across the samples. En ligne : http://dx.doi.org/10.1017/S0954579415000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings [Texte imprimé et/ou numérique] / Max OWENS, Auteur ; Ashley J. HARRISON, Auteur ; Katie L. BURKHOUSE, Auteur ; John E. MCGEARY, Auteur ; Valerie S. KNOPIK, Auteur ; Rohan H. C. PALMER, Auteur ; Brandon E. GIBB, Auteur . - p.385-397. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.385-397 Index. décimale : PER Périodiques Résumé : Information-processing biases may contribute to the intergenerational transmission of depression. There is growing evidence that children of depressed mothers exhibit attentional biases for sad faces. However, findings are mixed as to whether this bias reflects preferential attention toward, versus attentional avoidance of, sad faces, suggesting the presence of unmeasured moderators. To address these mixed findings, we focused on the potential moderating role of genes associated with hypothalamic–pituitary–adrenal axis reactivity. Participants included children (8–14 years old) of mothers with (n = 81) and without (n = 81) a history of depression. Eye movements were recorded while children passively viewed arrays of angry, happy, sad, and neutral faces. DNA was obtained from buccal cells. Children of depressed mothers exhibited more sustained attention to sad faces than did children of nondepressed mothers. However, it is important that this relation was moderated by children's genotype. Specifically, children of depressed mothers who carried reactive genotypes across the corticotropin-releasing hormone type 1 receptor (CHRH1) TAT haplotype and FK506 binding protein 5 (FKBP5) rs1360780 (but not the solute carrier family C6 member 4 [SLC6A4] of the serotonin transporter linked polymorphic region [5-HTTLPR]) exhibited less sustained attention to sad faces and more sustained attention to happy faces. These findings highlight the role played by specific genetic influences and suggest that previous mixed findings may have been due to genetic heterogeneity across the samples. En ligne : http://dx.doi.org/10.1017/S0954579415000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

The epigenetics of maternal cigarette smoking during pregnancy and effects on child development / Valerie S. KNOPIK in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1377-1390 Titre : The epigenetics of maternal cigarette smoking during pregnancy and effects on child development Type de document : Texte imprimé et/ou numérique Auteurs : Valerie S. KNOPIK, Auteur ; Matthew A. MACCANI, Auteur ; Sarah FRANCAZIO, Auteur ; John E. MCGEARY, Auteur Année de publication : 2012 Article en page(s) : p.1377-1390 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The period of in utero development is one of the most critical windows during which adverse intrauterine conditions and exposures can influence the growth and development of the fetus as well as the child's future postnatal health and behavior. Maternal cigarette smoking during pregnancy remains a relatively common but nonetheless hazardous in utero exposure. Previous studies have associated prenatal smoke exposure with reduced birth weight, poor developmental and psychological outcomes, and increased risk for diseases and behavioral disorders later in life. Researchers are now learning that many of the mechanisms whereby maternal smoke exposure may affect key pathways crucial for proper fetal growth and development are epigenetic in nature. Maternal cigarette smoking during pregnancy has been associated with altered DNA methylation and dysregulated expression of microRNA, but a deeper understanding of the epigenetics of maternal cigarette smoking during pregnancy as well as how these epigenetic changes may affect later health and behavior remain to be elucidated. This article seeks to explore many of the previously described epigenetic alterations associated with maternal cigarette smoking during pregnancy and assess how such changes may have consequences for both fetal growth and development, as well as later child health, behavior, and well-being. We also outline future directions for this new and exciting field of research. En ligne : http://dx.doi.org/10.1017/S0954579412000776 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] The epigenetics of maternal cigarette smoking during pregnancy and effects on child development [Texte imprimé et/ou numérique] / Valerie S. KNOPIK, Auteur ; Matthew A. MACCANI, Auteur ; Sarah FRANCAZIO, Auteur ; John E. MCGEARY, Auteur . - 2012 . - p.1377-1390. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1377-1390 Index. décimale : PER Périodiques Résumé : The period of in utero development is one of the most critical windows during which adverse intrauterine conditions and exposures can influence the growth and development of the fetus as well as the child's future postnatal health and behavior. Maternal cigarette smoking during pregnancy remains a relatively common but nonetheless hazardous in utero exposure. Previous studies have associated prenatal smoke exposure with reduced birth weight, poor developmental and psychological outcomes, and increased risk for diseases and behavioral disorders later in life. Researchers are now learning that many of the mechanisms whereby maternal smoke exposure may affect key pathways crucial for proper fetal growth and development are epigenetic in nature. Maternal cigarette smoking during pregnancy has been associated with altered DNA methylation and dysregulated expression of microRNA, but a deeper understanding of the epigenetics of maternal cigarette smoking during pregnancy as well as how these epigenetic changes may affect later health and behavior remain to be elucidated. This article seeks to explore many of the previously described epigenetic alterations associated with maternal cigarette smoking during pregnancy and assess how such changes may have consequences for both fetal growth and development, as well as later child health, behavior, and well-being. We also outline future directions for this new and exciting field of research. En ligne : http://dx.doi.org/10.1017/S0954579412000776 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

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