Dépouillements

Autistic Spectrum Disorder: What Video EEG Can Reveal about Its Pathophysiology / Vilem NOVAK in Autism - Open Access, 8-4 ([01/10/2018])  

Public ISBD [article]  inAutism - Open Access > 8-4 [01/10/2018] . - 4 p. Titre : Autistic Spectrum Disorder: What Video EEG Can Reveal about Its Pathophysiology Type de document : Texte imprimé et/ou numérique Auteurs : Vilem NOVAK, Auteur ; Hana MEDRICKA, Auteur ; Kristyna MILKOVA PAVLIKOVA, Auteur ; Radim BRIDZIK, Auteur ; Vaclav PROCHAZKA, Auteur ; Lubomir PAVLISKA, Auteur ; Jaroslav HAVELKA, Auteur ; Marcela KVARDOVA, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Autism  Video EEG  Coherence  Connectivity  Epileptiform discharges Index. décimale : PER Périodiques Résumé : Objective: The autistic spectrum disorder (ASD) is a lifelong disorder characterized by a defect in communication, social interaction and stereotype patterns of behavior. The etiology of ASD is probably heterogenous. EEG abnormalities were observed in autistic patients, but these findings are mostly based on the visual analysis and scarce studies used quantified EEG parameters. Changes in connectivity of various parts of brain cortex were described in some studies and that is why we decided to investigate an EEG measure which is capable to evaluate the connectivity: The coherence. Study aims are to, 1. Assess the hypothesis of connectivity changes; 2. Assess the impact of epileptiform discharges on neuropsychological development. Methods: We present a small study of 24 children with ASD who underwent complex neuropsychological, neurological, sleep video-EEG (whole night and part-day) and MRI of brain investigations. The video EEG and MRI data are compared with quasi-normal EEG and MRI data from the control group. The EEG data were evaluated by experienced EEG reader and then the parts of EEG in relaxed wakefulness were quantified in terms of inter-channel coherence in several EEG channels. Results: A coherence analysis across several EEG channels revealed a statistically significant correlation between inter hemispheric coherence of the rear temporal regions (T5-T6) at 16-31 Hz and Childhood Autism Rating Scale raw scores. Conclusion: The changes in connectivity measured by the coherence might be a part of pathophysiology of the ASD. En ligne : https://dx.doi.org/10.4172/2165-7890.1000234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Autistic Spectrum Disorder: What Video EEG Can Reveal about Its Pathophysiology [Texte imprimé et/ou numérique] / Vilem NOVAK, Auteur ; Hana MEDRICKA, Auteur ; Kristyna MILKOVA PAVLIKOVA, Auteur ; Radim BRIDZIK, Auteur ; Vaclav PROCHAZKA, Auteur ; Lubomir PAVLISKA, Auteur ; Jaroslav HAVELKA, Auteur ; Marcela KVARDOVA, Auteur . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 8-4 [01/10/2018] . - 4 p. Mots-clés : Autism  Video EEG  Coherence  Connectivity  Epileptiform discharges Index. décimale : PER Périodiques Résumé : Objective: The autistic spectrum disorder (ASD) is a lifelong disorder characterized by a defect in communication, social interaction and stereotype patterns of behavior. The etiology of ASD is probably heterogenous. EEG abnormalities were observed in autistic patients, but these findings are mostly based on the visual analysis and scarce studies used quantified EEG parameters. Changes in connectivity of various parts of brain cortex were described in some studies and that is why we decided to investigate an EEG measure which is capable to evaluate the connectivity: The coherence. Study aims are to, 1. Assess the hypothesis of connectivity changes; 2. Assess the impact of epileptiform discharges on neuropsychological development. Methods: We present a small study of 24 children with ASD who underwent complex neuropsychological, neurological, sleep video-EEG (whole night and part-day) and MRI of brain investigations. The video EEG and MRI data are compared with quasi-normal EEG and MRI data from the control group. The EEG data were evaluated by experienced EEG reader and then the parts of EEG in relaxed wakefulness were quantified in terms of inter-channel coherence in several EEG channels. Results: A coherence analysis across several EEG channels revealed a statistically significant correlation between inter hemispheric coherence of the rear temporal regions (T5-T6) at 16-31 Hz and Childhood Autism Rating Scale raw scores. Conclusion: The changes in connectivity measured by the coherence might be a part of pathophysiology of the ASD. En ligne : https://dx.doi.org/10.4172/2165-7890.1000234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Evolution and Preliminary Testing of a Hyperoxic Therapy for Autism Spectrum Disorders / R.E. PETERSON in Autism - Open Access, 8-4 ([01/10/2018])  

Public ISBD [article]  inAutism - Open Access > 8-4 [01/10/2018] . - 17 p. Titre : Evolution and Preliminary Testing of a Hyperoxic Therapy for Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : R.E. PETERSON, Auteur ; M.W. ALLEN, Auteur Article en page(s) : 17 p. Langues : Anglais (eng) Mots-clés : Normobaric  Hyperbaric  Microbaric  Oxygen  Hyperoxic  Autism Index. décimale : PER Périodiques Résumé : The diagnosis of autism spectrum disorders (ASD) comprises a range of developmental disabilities, the established prevalence of which has been increasing globally. Despite decades of research, however, ASD is still not well understood and a generally accepted intervention or group of interventions which consistently and comprehensively address the spectrum of needs has not yet been identified or developed. Thus, in seeking a solution to their children's conditions, some parents have felt compelled to try complementary and alternative medical treatments. One such intervention that has attracted some advocates is off-label hyperbaric oxygen therapy. In examining the data for this application, we were struck by the wide range of oxygen partial pressures reported to have benefit and the fact that many could be easily provided at normobaric pressure. As we knew of no reason for the use of increased pressure in treating ASD with hyperoxic therapy, we determined to find out if benefits could be obtained from such treatments at normal atmospheric pressure. A pilot study with five cases involving preteens and teenagers with autism was conducted using a normobaric form of hyperoxic treatment we have called Microbaric® Oxygen Therapy (MBO2). All five cases benefitted, three remarkably so. Improvements were across the full range of symptoms of autism, and no regression was reported on cessation of treatment or during follow up for as long as six years. Thus, it appears that the outcomes of MBO2 for autism are permanent. As a consequence of this pilot study, it would seem imperative to conduct controlled research to confirm our findings. Should similar outcomes be obtained, then MBO2 would offer a new, cost-effective, and time efficient way forward as a stand-alone therapy or as an adjunct to other therapies in the treatment of autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Evolution and Preliminary Testing of a Hyperoxic Therapy for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / R.E. PETERSON, Auteur ; M.W. ALLEN, Auteur . - 17 p. Langues : Anglais (eng) in Autism - Open Access > 8-4 [01/10/2018] . - 17 p. Mots-clés : Normobaric  Hyperbaric  Microbaric  Oxygen  Hyperoxic  Autism Index. décimale : PER Périodiques Résumé : The diagnosis of autism spectrum disorders (ASD) comprises a range of developmental disabilities, the established prevalence of which has been increasing globally. Despite decades of research, however, ASD is still not well understood and a generally accepted intervention or group of interventions which consistently and comprehensively address the spectrum of needs has not yet been identified or developed. Thus, in seeking a solution to their children's conditions, some parents have felt compelled to try complementary and alternative medical treatments. One such intervention that has attracted some advocates is off-label hyperbaric oxygen therapy. In examining the data for this application, we were struck by the wide range of oxygen partial pressures reported to have benefit and the fact that many could be easily provided at normobaric pressure. As we knew of no reason for the use of increased pressure in treating ASD with hyperoxic therapy, we determined to find out if benefits could be obtained from such treatments at normal atmospheric pressure. A pilot study with five cases involving preteens and teenagers with autism was conducted using a normobaric form of hyperoxic treatment we have called Microbaric® Oxygen Therapy (MBO2). All five cases benefitted, three remarkably so. Improvements were across the full range of symptoms of autism, and no regression was reported on cessation of treatment or during follow up for as long as six years. Thus, it appears that the outcomes of MBO2 for autism are permanent. As a consequence of this pilot study, it would seem imperative to conduct controlled research to confirm our findings. Should similar outcomes be obtained, then MBO2 would offer a new, cost-effective, and time efficient way forward as a stand-alone therapy or as an adjunct to other therapies in the treatment of autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410