[article]
| Titre : |
Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Gitte Falcher MADSEN, Auteur ; Niels BILENBERG, Auteur ; Cathriona CANTIO, Auteur ; Bob ORANJE, Auteur |
| Article en page(s) : |
p.94-103 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
autism spectrum disorders PPI sensorimotor gating sensitization children auditory processing |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The relation between autism spectrum disorders (ASD) and schizophrenia is a subject of intense debate and research due to evidence of common neurobiological pathways in the two disorders. The objective of this study was to explore whether deficits in prepulse inhibition (PPI) of the startle reflex, as usually seen in schizophrenic patients, can be replicated in a group of children with ASD in comparison with a group of matched neuro-typically developed (NTD) controls. An additional aim was to explore possible psychophysiological subgroups within our ASD sample. In a case-control design, 35 ASD patients and 40 matched NTD controls were tested in a psychophysiological test battery. The PPI of the acoustic startle reflex was analyzed in 18 ASD subjects and 34 NTD controls. Habituation and sensitization were analyzed in 23 ASD subjects and 39 NTD controls. In trials with less intense prestimuli (76?dB), patients with ASD did not display the drop in percentage PPI normally found in healthy controls. In addition, ASD patients showed significantly increased sensitization compared with NTD controls. Combined, our results may reflect the hypersensitivity to sensory information in children with ASD. The relation to PPI deficits observed in schizophrenia is not apparent. Future research should study the developmental course of PPI deficits in ASD patients in a longitudinal design. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1337 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 |
in Autism Research > 7-1 (February 2014) . - p.94-103
[article] Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children [Texte imprimé et/ou numérique] / Gitte Falcher MADSEN, Auteur ; Niels BILENBERG, Auteur ; Cathriona CANTIO, Auteur ; Bob ORANJE, Auteur . - p.94-103. Langues : Anglais ( eng) in Autism Research > 7-1 (February 2014) . - p.94-103
| Mots-clés : |
autism spectrum disorders PPI sensorimotor gating sensitization children auditory processing |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The relation between autism spectrum disorders (ASD) and schizophrenia is a subject of intense debate and research due to evidence of common neurobiological pathways in the two disorders. The objective of this study was to explore whether deficits in prepulse inhibition (PPI) of the startle reflex, as usually seen in schizophrenic patients, can be replicated in a group of children with ASD in comparison with a group of matched neuro-typically developed (NTD) controls. An additional aim was to explore possible psychophysiological subgroups within our ASD sample. In a case-control design, 35 ASD patients and 40 matched NTD controls were tested in a psychophysiological test battery. The PPI of the acoustic startle reflex was analyzed in 18 ASD subjects and 34 NTD controls. Habituation and sensitization were analyzed in 23 ASD subjects and 39 NTD controls. In trials with less intense prestimuli (76?dB), patients with ASD did not display the drop in percentage PPI normally found in healthy controls. In addition, ASD patients showed significantly increased sensitization compared with NTD controls. Combined, our results may reflect the hypersensitivity to sensory information in children with ASD. The relation to PPI deficits observed in schizophrenia is not apparent. Future research should study the developmental course of PPI deficits in ASD patients in a longitudinal design. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1337 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 |
|
Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children in Autism Research, 7-1 (February 2014)
