Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children / Haitham M. HASHIM in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.199–204 Titre : Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children Type de document : Texte imprimé et/ou numérique Auteurs : Haitham M. HASHIM, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Doaa MOHAMMED, Auteur ; Rehab KARAM, Auteur Année de publication : 2013 Article en page(s) : p.199–204 Langues : Anglais (eng) Mots-clés : Autism  Transforming growth factor-β1  IL-23  IL-17 Index. décimale : PER Périodiques Résumé : It has been recently shown that dysregulation of transforming growth factor-β1 (TGF-β1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-β 1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-β1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6–12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-β1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P < 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-β1 with IL-17 in children with ASD. There was a negative correlation between TGF-β1, IL-23 and IL-17 with the severity of autism (P < 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 [article] Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children [Texte imprimé et/ou numérique] / Haitham M. HASHIM, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Doaa MOHAMMED, Auteur ; Rehab KARAM, Auteur . - 2013 . - p.199–204. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.199–204 Mots-clés : Autism  Transforming growth factor-β1  IL-23  IL-17 Index. décimale : PER Périodiques Résumé : It has been recently shown that dysregulation of transforming growth factor-β1 (TGF-β1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-β 1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-β1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6–12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-β1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P < 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-β1 with IL-17 in children with ASD. There was a negative correlation between TGF-β1, IL-23 and IL-17 with the severity of autism (P < 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181

Blood and brain glutamate levels in children with autistic disorder / Tamer H. HASSAN in Research in Autism Spectrum Disorders, 7-4 (April 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-4 (April 2013) . - p.541-548 Titre : Blood and brain glutamate levels in children with autistic disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tamer H. HASSAN, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Nelly R. ABDEL FATTAH, Auteur ; Nagda M. EL-MASRY, Auteur ; Haitham M. HASHIM, Auteur ; Khaled M. EL-GERBY, Auteur ; Nermin R. ABDEL FATTAH, Auteur Article en page(s) : p.541-548 Langues : Anglais (eng) Mots-clés : Blood glutamate  Brain glutamate  Autism Index. décimale : PER Périodiques Résumé : Despite of the great efforts that move forward to clarify the pathophysiologic mechanisms in autism, the cause of this disorder, however, remains largely unknown. There is an increasing body of literature concerning neurochemical contributions to the pathophysiology of autism. We aimed to determine blood and brain levels of glutamate in children with autistic disorder and to correlate between them. The study included 10 children with autism and 10 age- and sex-matched healthy controls. Blood glutamate levels were measured using high performance liquid chromatography technique. Brain glutamate levels were measured using proton magnetic resonance spectroscopy. The mean blood and brain glutamate levels were significantly higher in patients than controls (p lt; 0.001). There was highly significant positive correlation between blood glutamate level and brain glutamate levels in the four tested brain regions (p lt; 0.001). Glutamate plays an important role in the pathogenesis of autism. Further larger studies are required to support our findings. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Blood and brain glutamate levels in children with autistic disorder [Texte imprimé et/ou numérique] / Tamer H. HASSAN, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Nelly R. ABDEL FATTAH, Auteur ; Nagda M. EL-MASRY, Auteur ; Haitham M. HASHIM, Auteur ; Khaled M. EL-GERBY, Auteur ; Nermin R. ABDEL FATTAH, Auteur . - p.541-548. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-4 (April 2013) . - p.541-548 Mots-clés : Blood glutamate  Brain glutamate  Autism Index. décimale : PER Périodiques Résumé : Despite of the great efforts that move forward to clarify the pathophysiologic mechanisms in autism, the cause of this disorder, however, remains largely unknown. There is an increasing body of literature concerning neurochemical contributions to the pathophysiology of autism. We aimed to determine blood and brain levels of glutamate in children with autistic disorder and to correlate between them. The study included 10 children with autism and 10 age- and sex-matched healthy controls. Blood glutamate levels were measured using high performance liquid chromatography technique. Brain glutamate levels were measured using proton magnetic resonance spectroscopy. The mean blood and brain glutamate levels were significantly higher in patients than controls (p lt; 0.001). There was highly significant positive correlation between blood glutamate level and brain glutamate levels in the four tested brain regions (p lt; 0.001). Glutamate plays an important role in the pathogenesis of autism. Further larger studies are required to support our findings. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

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