[article] 
inResearch in Autism Spectrum Disorders > 8-7 (July 2014) . - p.803-813

Titre :	Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Amanda SAWYER, Auteur ; Johanna K. LAKE, Auteur ; Yona LUNSKY, Auteur ; Shi-Kai LIU, Auteur ; Pushpal DESARKAR, Auteur
Article en page(s) :	p.803-813
Langues :	Anglais (eng)
Mots-clés :	Autism  Adults  Challenging behaviours  Psychopharmacology  Intellectual disability
Index. décimale :	PER Périodiques
Résumé :	AbstractIntroduction Autism is a neurodevelopmental disorder with a high co-occurrence with intellectual disability. Adults with Autism and intellectual disability have a high incidence of challenging behaviour, defined as repetitive self injurious or aggressive behaviour. We underwent a systemic review of the evidence for treating challenging behaviours in adults with Autism and intellectual disability. Methods A literature search was conducted using three large databases to extract studies on the treatment of challenging behaviour among adults with Autism and intellectual disability. Papers, which met this criterion, were reviewed and analysed to assess study evidence and quality. Results Seven articles were selected which included five agents: fluvoxamine, sertraline, clomipramine, risperidone, and ziprasidone. Randomized control studies of fluvoxamine and risperidone, provided efficacy for the treatment of challenging behaviour in adults with Autism and intellectual disability. Open label trials of sertraline, clomipramine and ziprasidone were also effective in treating challenging behaviours for this population. Discussion Risperidone and fluvoxamine provided the best evidence for treating challenging behaviour, and risperidone was the only medication with multiple trials showing its efficacy. Further studies are required to demonstrate the efficacy of psychopharmacology in treating challenging behaviours among adults with Autism and intellectual disability.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2014.03.021
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

[article] Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review [Texte imprimé et/ou numérique] / Amanda SAWYER, Auteur ; Johanna K. LAKE, Auteur ; Yona LUNSKY, Auteur ; Shi-Kai LIU, Auteur ; Pushpal DESARKAR, Auteur . - p.803-813.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.803-813

Mots-clés :	Autism  Adults  Challenging behaviours  Psychopharmacology  Intellectual disability
Index. décimale :	PER Périodiques
Résumé :	AbstractIntroduction Autism is a neurodevelopmental disorder with a high co-occurrence with intellectual disability. Adults with Autism and intellectual disability have a high incidence of challenging behaviour, defined as repetitive self injurious or aggressive behaviour. We underwent a systemic review of the evidence for treating challenging behaviours in adults with Autism and intellectual disability. Methods A literature search was conducted using three large databases to extract studies on the treatment of challenging behaviour among adults with Autism and intellectual disability. Papers, which met this criterion, were reviewed and analysed to assess study evidence and quality. Results Seven articles were selected which included five agents: fluvoxamine, sertraline, clomipramine, risperidone, and ziprasidone. Randomized control studies of fluvoxamine and risperidone, provided efficacy for the treatment of challenging behaviour in adults with Autism and intellectual disability. Open label trials of sertraline, clomipramine and ziprasidone were also effective in treating challenging behaviours for this population. Discussion Risperidone and fluvoxamine provided the best evidence for treating challenging behaviour, and risperidone was the only medication with multiple trials showing its efficacy. Further studies are required to demonstrate the efficacy of psychopharmacology in treating challenging behaviours among adults with Autism and intellectual disability.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2014.03.021
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233