Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism / Estate M. SOKHADZE in Journal of Autism and Developmental Disorders, 39-4 (April 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-4 (April 2009) . - p.619-634 Titre : Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Estate M. SOKHADZE, Auteur ; Manuel F. CASANOVA, Auteur ; Lonnie L. SEARS, Auteur ; Ayman S. EL-BAZ, Auteur ; Grace MATHAI, Auteur ; Joshua M. BARUTH, Auteur Année de publication : 2009 Article en page(s) : p.619-634 Langues : Anglais (eng) Mots-clés : Autism Minicolumns Event-related-potentials Electroencephalography Gamma-frequencies Index. décimale : PER Périodiques Résumé : Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism. En ligne : http://dx.doi.org/10.1007/s10803-008-0662-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=706 [article] Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism [Texte imprimé et/ou numérique] / Estate M. SOKHADZE, Auteur ; Manuel F. CASANOVA, Auteur ; Lonnie L. SEARS, Auteur ; Ayman S. EL-BAZ, Auteur ; Grace MATHAI, Auteur ; Joshua M. BARUTH, Auteur . - 2009 . - p.619-634. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-4 (April 2009) . - p.619-634 Mots-clés : Autism Minicolumns Event-related-potentials Electroencephalography Gamma-frequencies Index. décimale : PER Périodiques Résumé : Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism. En ligne : http://dx.doi.org/10.1007/s10803-008-0662-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=706

Event-Related Potential Studies of Cognitive Processing Abnormalities in Autism / Estate M. SOKHADZE

Public ISBD in Imaging the Brain in Autism / Manuel F. CASANOVA Titre : Event-Related Potential Studies of Cognitive Processing Abnormalities in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Estate M. SOKHADZE, Auteur ; Joshua M. BARUTH, Auteur ; Allan TASMAN, Auteur ; Manuel F. CASANOVA, Auteur Année de publication : 2013 Importance : p.61-86 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 in Imaging the Brain in Autism / Manuel F. CASANOVA Event-Related Potential Studies of Cognitive Processing Abnormalities in Autism [Texte imprimé et/ou numérique] / Estate M. SOKHADZE, Auteur ; Joshua M. BARUTH, Auteur ; Allan TASMAN, Auteur ; Manuel F. CASANOVA, Auteur . - 2013 . - p.61-86. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

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Evoked and Induced Gamma-Frequency Oscillations in Autism / Manuel F. CASANOVA

Public ISBD in Imaging the Brain in Autism / Manuel F. CASANOVA Titre : Evoked and Induced Gamma-Frequency Oscillations in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Manuel F. CASANOVA, Auteur ; Joshua M. BARUTH, Auteur ; Ayman S. EL-BAZ, Auteur ; Guela E. SOKHADZE, Auteur ; Marie HENSLEY, Auteur ; Estate M. SOKHADZE, Auteur Année de publication : 2013 Importance : p.87-106 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 in Imaging the Brain in Autism / Manuel F. CASANOVA Evoked and Induced Gamma-Frequency Oscillations in Autism [Texte imprimé et/ou numérique] / Manuel F. CASANOVA, Auteur ; Joshua M. BARUTH, Auteur ; Ayman S. EL-BAZ, Auteur ; Guela E. SOKHADZE, Auteur ; Marie HENSLEY, Auteur ; Estate M. SOKHADZE, Auteur . - 2013 . - p.87-106. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

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Proton Magnetic Resonance Spectroscopy as a Probe into the Pathophysiology of Autism Spectrum Disorders (ASD): A Review / Joshua M. BARUTH in Autism Research, 6-2 (April 2013)  

Public ISBD [article]  inAutism Research > 6-2 (April 2013) . - p.119-133 Titre : Proton Magnetic Resonance Spectroscopy as a Probe into the Pathophysiology of Autism Spectrum Disorders (ASD): A Review Type de document : Texte imprimé et/ou numérique Auteurs : Joshua M. BARUTH, Auteur ; Christopher A. WALL, Auteur ; Marc C. PATTERSON, Auteur ; John D. PORT, Auteur Année de publication : 2013 Article en page(s) : p.119-133 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorders  proton magnetic resonance spectroscopy  N-acetylaspartate  glutamate  myo-inositol Index. décimale : PER Périodiques Résumé : Proton magnetic resonance spectroscopy (1H-MRS) is a safe, noninvasive way of quantifying in vivo biochemical and metabolite concentration levels in individuals with Autism Spectrum Disorders (ASD). Findings to date suggest ASD is associated with widespread reduction in N-acetylaspartate (NAA), creatine plus phosphocreatine (Cr), choline-containing compounds (Cho), myo-inositol (mI), and glutamate plus glutamine plus gamma-Aminobutyric Acid (Glx); however, variable findings, and even substantial increases, are not uncommon depending on the study and/or region-of-interest. Widespread reduction of NAA, Cr, Cho, mI, and Glx in ASD likely reflects impaired neuronal function and/or metabolism related to abnormal neurodevelopmental processes. Future studies should attempt to relate 1H-MRS findings to histological findings and control for variability in subject age and functioning level; this would assist in evaluating the relationship between 1H-MRS metabolic levels and neuronal and glial cell densities, as well as neurodevelopmental process associated with ASD. Furthermore, more longitudinal 1H-MRS studies are needed in both control and ASD subjects to attempt to standardize metabolite levels across different developmental periods in well-defined endophenotypes. This will provide for a standard rubric for which metabolic aberrations (as well as treatment responses) can be measured. With higher magnetic field strengths and spectral-editing techniques capable of quantifying less-concentrated metabolites, 1H-MRS will continue to be an important tool in ASD research. En ligne : http://dx.doi.org/10.1002/aur.1273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Proton Magnetic Resonance Spectroscopy as a Probe into the Pathophysiology of Autism Spectrum Disorders (ASD): A Review [Texte imprimé et/ou numérique] / Joshua M. BARUTH, Auteur ; Christopher A. WALL, Auteur ; Marc C. PATTERSON, Auteur ; John D. PORT, Auteur . - 2013 . - p.119-133. Langues : Anglais (eng) in Autism Research > 6-2 (April 2013) . - p.119-133 Mots-clés : Autism Spectrum Disorders  proton magnetic resonance spectroscopy  N-acetylaspartate  glutamate  myo-inositol Index. décimale : PER Périodiques Résumé : Proton magnetic resonance spectroscopy (1H-MRS) is a safe, noninvasive way of quantifying in vivo biochemical and metabolite concentration levels in individuals with Autism Spectrum Disorders (ASD). Findings to date suggest ASD is associated with widespread reduction in N-acetylaspartate (NAA), creatine plus phosphocreatine (Cr), choline-containing compounds (Cho), myo-inositol (mI), and glutamate plus glutamine plus gamma-Aminobutyric Acid (Glx); however, variable findings, and even substantial increases, are not uncommon depending on the study and/or region-of-interest. Widespread reduction of NAA, Cr, Cho, mI, and Glx in ASD likely reflects impaired neuronal function and/or metabolism related to abnormal neurodevelopmental processes. Future studies should attempt to relate 1H-MRS findings to histological findings and control for variability in subject age and functioning level; this would assist in evaluating the relationship between 1H-MRS metabolic levels and neuronal and glial cell densities, as well as neurodevelopmental process associated with ASD. Furthermore, more longitudinal 1H-MRS studies are needed in both control and ASD subjects to attempt to standardize metabolite levels across different developmental periods in well-defined endophenotypes. This will provide for a standard rubric for which metabolic aberrations (as well as treatment responses) can be measured. With higher magnetic field strengths and spectral-editing techniques capable of quantifying less-concentrated metabolites, 1H-MRS will continue to be an important tool in ASD research. En ligne : http://dx.doi.org/10.1002/aur.1273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

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