[article] 
inDevelopment and Psychopathology > 27-2 (May 2015) . - p.615-635

Titre :	Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Matcheri S. KESHAVAN, Auteur ; Urvakhsh Meherwan MEHTA, Auteur ; Jaya L. PADMANABHAN, Auteur ; Jai L. SHAH, Auteur
Article en page(s) :	p.615-635
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	In this paper, we review the history of the concept of neuroplasticity as it relates to the understanding of neuropsychiatric disorders, using schizophrenia as a case in point. We briefly review the myriad meanings of the term neuroplasticity, and its neuroscientific basis. We then review the evidence for aberrant neuroplasticity and metaplasticity associated with schizophrenia as well as the risk for developing this illness, and discuss the implications of such understanding for prevention and therapeutic interventions. We argue that the failure and/or altered timing of plasticity of critical brain circuits might underlie cognitive and deficit symptoms, and may also lead to aberrant plastic reorganization in other circuits, leading to affective dysregulation and eventually psychosis. This “dysplastic” model of schizophrenia can suggest testable etiology and treatment-relevant questions for the future.
En ligne :	http://dx.doi.org/10.1017/S095457941500019X
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

[article] Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions [Texte imprimé et/ou numérique] / Matcheri S. KESHAVAN, Auteur ; Urvakhsh Meherwan MEHTA, Auteur ; Jaya L. PADMANABHAN, Auteur ; Jai L. SHAH, Auteur . - p.615-635.
Langues : Anglais (eng)
in Development and Psychopathology > 27-2 (May 2015) . - p.615-635

Index. décimale :	PER Périodiques
Résumé :	In this paper, we review the history of the concept of neuroplasticity as it relates to the understanding of neuropsychiatric disorders, using schizophrenia as a case in point. We briefly review the myriad meanings of the term neuroplasticity, and its neuroscientific basis. We then review the evidence for aberrant neuroplasticity and metaplasticity associated with schizophrenia as well as the risk for developing this illness, and discuss the implications of such understanding for prevention and therapeutic interventions. We argue that the failure and/or altered timing of plasticity of critical brain circuits might underlie cognitive and deficit symptoms, and may also lead to aberrant plastic reorganization in other circuits, leading to affective dysregulation and eventually psychosis. This “dysplastic” model of schizophrenia can suggest testable etiology and treatment-relevant questions for the future.
En ligne :	http://dx.doi.org/10.1017/S095457941500019X
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257