Dimensional psychopathology in preschool offspring of parents with bipolar disorder / Hagai MAOZ in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.144-153 Titre : Dimensional psychopathology in preschool offspring of parents with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hagai MAOZ, Auteur ; Tina R. GOLDSTEIN, Auteur ; David A. AXELSON, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jieyu FAN, Auteur ; Mary Beth HICKEY, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Rasim S. DILER, Auteur ; David A. BRENT, Auteur ; Satish IYENGAR, Auteur ; David J. KUPFER, Auteur ; Boris BIRMAHER, Auteur Article en page(s) : p.144-153 Langues : Anglais (eng) Mots-clés : BP  offspring  dimensional psychopathology Index. décimale : PER Périodiques Résumé : Background The purpose of this study is to compare the dimensional psychopathology, as ascertained by parental report, in preschool offspring of parents with bipolar disorder (BP) and offspring of community control parents. Methods 122 preschool offspring (mean age 3.3 years) of 84 parents with BP, with 102 offspring of 65 control parents (36 healthy, 29 with non-BP psychopathology), were evaluated using the Child Behavior Checklist (CBCL), the CBCL-Dysregulation Profile (CBCL-DP), the Early Childhood Inventory (ECI-4), and the Emotionality Activity Sociability (EAS) survey. Teachers' Report Forms (TRF) were available for 51 preschoolers. Results After adjusting for confounders, offspring of parents with BP showed higher scores in the CBCL total, externalizing, somatic, sleep, aggressive, and CBCL-DP subscales; the ECI-4 sleep problem scale; and the EAS total and emotionality scale. The proportion of offspring with CBCL T-scores ?2 SD above the norm was significantly higher on most CBCL subscales and the CBCL-DP in offspring of parents with BP compared to offspring of controls even after excluding offspring with attention deficit hyperactivity disorder and/or oppositional defiant disorder. Compared to offspring of parents with BP-I, offspring of parents with BP-II showed significantly higher scores in total and most CBCL subscales, the ECI-4 anxiety and sleep scales and the EAS emotionality scale. For both groups of parents, there were significant correlations between CBCL and TRF scores (r = .32–.38, p-values ?.02). Conclusions Independent of categorical axis-I psychopathology and other demographic or clinical factors in both biological parents, preschool offspring of parents with BP have significantly greater aggression, mood dysregulation, sleep disturbances, and somatic complaints compared to offspring of control parents. Interventions to target these symptoms are warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Dimensional psychopathology in preschool offspring of parents with bipolar disorder [Texte imprimé et/ou numérique] / Hagai MAOZ, Auteur ; Tina R. GOLDSTEIN, Auteur ; David A. AXELSON, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jieyu FAN, Auteur ; Mary Beth HICKEY, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Rasim S. DILER, Auteur ; David A. BRENT, Auteur ; Satish IYENGAR, Auteur ; David J. KUPFER, Auteur ; Boris BIRMAHER, Auteur . - p.144-153. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.144-153 Mots-clés : BP  offspring  dimensional psychopathology Index. décimale : PER Périodiques Résumé : Background The purpose of this study is to compare the dimensional psychopathology, as ascertained by parental report, in preschool offspring of parents with bipolar disorder (BP) and offspring of community control parents. Methods 122 preschool offspring (mean age 3.3 years) of 84 parents with BP, with 102 offspring of 65 control parents (36 healthy, 29 with non-BP psychopathology), were evaluated using the Child Behavior Checklist (CBCL), the CBCL-Dysregulation Profile (CBCL-DP), the Early Childhood Inventory (ECI-4), and the Emotionality Activity Sociability (EAS) survey. Teachers' Report Forms (TRF) were available for 51 preschoolers. Results After adjusting for confounders, offspring of parents with BP showed higher scores in the CBCL total, externalizing, somatic, sleep, aggressive, and CBCL-DP subscales; the ECI-4 sleep problem scale; and the EAS total and emotionality scale. The proportion of offspring with CBCL T-scores ?2 SD above the norm was significantly higher on most CBCL subscales and the CBCL-DP in offspring of parents with BP compared to offspring of controls even after excluding offspring with attention deficit hyperactivity disorder and/or oppositional defiant disorder. Compared to offspring of parents with BP-I, offspring of parents with BP-II showed significantly higher scores in total and most CBCL subscales, the ECI-4 anxiety and sleep scales and the EAS emotionality scale. For both groups of parents, there were significant correlations between CBCL and TRF scores (r = .32–.38, p-values ?.02). Conclusions Independent of categorical axis-I psychopathology and other demographic or clinical factors in both biological parents, preschool offspring of parents with BP have significantly greater aggression, mood dysregulation, sleep disturbances, and somatic complaints compared to offspring of control parents. Interventions to target these symptoms are warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder / Danella M. HAFEMAN in Journal of Child Psychology and Psychiatry, 64-10 (October 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Titre : Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur Article en page(s) : p.1492-1500 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5?years old) and then approximately every 2?years for a mean of 10.6?years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder [Texte imprimé et/ou numérique] / Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur . - p.1492-1500. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5?years old) and then approximately every 2?years for a mean of 10.6?years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

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