Interplay between genetic risk and the parent environment in adolescence and substance use in young adulthood: A TRAILS study / Joëlle A. PASMAN in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.396-409 Titre : Interplay between genetic risk and the parent environment in adolescence and substance use in young adulthood: A TRAILS study Type de document : Texte imprimé et/ou numérique Auteurs : Joëlle A. PASMAN, Auteur ; Koen SMIT, Auteur ; Wilma A. M. VOLLEBERGH, Auteur ; Ilja M. NOLTE, Auteur ; Catharina A. HARTMAN, Auteur ; Abdel ABDELLAOUI, Auteur ; Karin J. H. VERWEIJ, Auteur ; Dominique MACIEJEWSKI, Auteur ; Jacqueline M. VINK, Auteur Article en page(s) : p.396-409 Langues : Anglais (eng) Mots-clés : Gene*Environment interaction  genetic nurturing  parenting  smoking  substance use Index. décimale : PER Périodiques Résumé : Many adolescents start using tobacco, alcohol, and cannabis. Genetic vulnerability, parent characteristics in young adolescence, and interaction (GxE) and correlation (rGE) between these factors could contribute to the development of substance use. Using prospective data from the TRacking Adolescent Individuals' Lives Survey (TRAILS; N = 1,645), we model latent parent characteristics in young adolescence to predict young adult substance use. Polygenic scores (PGS) are created based on genome-wide association studies (GWAS) for smoking, alcohol use, and cannabis use. Using structural equation modeling we model the direct, GxE, and rGE effects of parent factors and PGS on young adult smoking, alcohol use, and cannabis initiation. The PGS, parental involvement, parental substance use, and parent-child relationship quality predicted smoking. There was GxE such that the PGS amplified the effect of parental substance use on smoking. There was rGE between all parent factors and the smoking PGS. Alcohol use was not predicted by genetic or parent factors, nor by interplay. Cannabis initiation was predicted by the PGS and parental substance use, but there was no GxE or rGE. Genetic risk and parent factors are important predictors of substance use and show GxE and rGE in smoking. These findings can act as a starting point for identifying people at risk. En ligne : https://doi.org/10.1017/S095457942100081X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Interplay between genetic risk and the parent environment in adolescence and substance use in young adulthood: A TRAILS study [Texte imprimé et/ou numérique] / Joëlle A. PASMAN, Auteur ; Koen SMIT, Auteur ; Wilma A. M. VOLLEBERGH, Auteur ; Ilja M. NOLTE, Auteur ; Catharina A. HARTMAN, Auteur ; Abdel ABDELLAOUI, Auteur ; Karin J. H. VERWEIJ, Auteur ; Dominique MACIEJEWSKI, Auteur ; Jacqueline M. VINK, Auteur . - p.396-409. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.396-409 Mots-clés : Gene*Environment interaction  genetic nurturing  parenting  smoking  substance use Index. décimale : PER Périodiques Résumé : Many adolescents start using tobacco, alcohol, and cannabis. Genetic vulnerability, parent characteristics in young adolescence, and interaction (GxE) and correlation (rGE) between these factors could contribute to the development of substance use. Using prospective data from the TRacking Adolescent Individuals' Lives Survey (TRAILS; N = 1,645), we model latent parent characteristics in young adolescence to predict young adult substance use. Polygenic scores (PGS) are created based on genome-wide association studies (GWAS) for smoking, alcohol use, and cannabis use. Using structural equation modeling we model the direct, GxE, and rGE effects of parent factors and PGS on young adult smoking, alcohol use, and cannabis initiation. The PGS, parental involvement, parental substance use, and parent-child relationship quality predicted smoking. There was GxE such that the PGS amplified the effect of parental substance use on smoking. There was rGE between all parent factors and the smoking PGS. Alcohol use was not predicted by genetic or parent factors, nor by interplay. Cannabis initiation was predicted by the PGS and parental substance use, but there was no GxE or rGE. Genetic risk and parent factors are important predictors of substance use and show GxE and rGE in smoking. These findings can act as a starting point for identifying people at risk. En ligne : https://doi.org/10.1017/S095457942100081X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Sequences of maladaptation: Preadolescent self-regulation, adolescent negative social interactions, and young adult psychopathology / Odilia M. LACEULLE in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.279-292 Titre : Sequences of maladaptation: Preadolescent self-regulation, adolescent negative social interactions, and young adult psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Odilia M. LACEULLE, Auteur ; René VEENSTRA, Auteur ; Wilma A. M. VOLLEBERGH, Auteur ; Johan ORMEL, Auteur Article en page(s) : p.279-292 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study aims to test whether adolescent negative social interactions mediate the relation between early adolescent self-regulatory capacities and young adult psychopathology, using a fully prospective mediation model. Data were derived from the Tracking Adolescents’ Individual Lives Survey, a large population cohort of Dutch adolescents (n = 962). At age 11, three indicators of self-regulation were assessed: low frustration, high effortful control, and high response inhibition. Negative social interactions between ages 11 and 22 were captured twice using the Event History Calendar. Psychopathology (i.e., internalizing and externalizing problems) was assessed at ages 11 and 22. Findings indicate that adolescents’ frustration and effortful control but not response inhibition assessed at age 11 are related to both internalizing and externalizing problems at age 22, after controlling for psychopathology at age 11, sex, and socioeconomic status. These associations were partly (about 22%) mediated by the negative social interactions adolescents experienced. Effect sizes were all modest. This study shows that self-regulation is related to subsequent psychopathology in part through its effect on negative social interactions, providing evidence for sequences of self-regulatory capacities, life experiences, and developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Sequences of maladaptation: Preadolescent self-regulation, adolescent negative social interactions, and young adult psychopathology [Texte imprimé et/ou numérique] / Odilia M. LACEULLE, Auteur ; René VEENSTRA, Auteur ; Wilma A. M. VOLLEBERGH, Auteur ; Johan ORMEL, Auteur . - p.279-292. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.279-292 Index. décimale : PER Périodiques Résumé : This study aims to test whether adolescent negative social interactions mediate the relation between early adolescent self-regulatory capacities and young adult psychopathology, using a fully prospective mediation model. Data were derived from the Tracking Adolescents’ Individual Lives Survey, a large population cohort of Dutch adolescents (n = 962). At age 11, three indicators of self-regulation were assessed: low frustration, high effortful control, and high response inhibition. Negative social interactions between ages 11 and 22 were captured twice using the Event History Calendar. Psychopathology (i.e., internalizing and externalizing problems) was assessed at ages 11 and 22. Findings indicate that adolescents’ frustration and effortful control but not response inhibition assessed at age 11 are related to both internalizing and externalizing problems at age 22, after controlling for psychopathology at age 11, sex, and socioeconomic status. These associations were partly (about 22%) mediated by the negative social interactions adolescents experienced. Effect sizes were all modest. This study shows that self-regulation is related to subsequent psychopathology in part through its effect on negative social interactions, providing evidence for sequences of self-regulatory capacities, life experiences, and developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

A test of the vulnerability model: temperament and temperament change as predictors of future mental disorders – the TRAILS study / Odilia M. LACEULLE in Journal of Child Psychology and Psychiatry, 55-3 (March 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-3 (March 2014) . - p.227-236 Titre : A test of the vulnerability model: temperament and temperament change as predictors of future mental disorders – the TRAILS study Type de document : Texte imprimé et/ou numérique Auteurs : Odilia M. LACEULLE, Auteur ; Johan ORMEL, Auteur ; Wilma A. M. VOLLEBERGH, Auteur ; Marcel A. G. VAN AKEN, Auteur ; Esther NEDERHOF, Auteur Article en page(s) : p.227-236 Langues : Anglais (eng) Mots-clés : Mental disorders  temperament traits  temperament change  vulnerability model Index. décimale : PER Périodiques Résumé : Background This study aimed to test the vulnerability model of the relationship between temperament and mental disorders using a large sample of adolescents from the TRacking Adolescents Individual Lives' Survey (TRAILS). The vulnerability model argues that particular temperaments can place individuals at risk for the development of mental health problems. Importantly, the model may imply that not only baseline temperament predicts mental health problems prospectively, but additionally, that changes in temperament predict corresponding changes in risk for mental health problems. Methods Data were used from 1195 TRAILS participants. Adolescent temperament was assessed both at age 11 and at age 16. Onset of mental disorders between age 16 and 19 was assessed at age 19, by means of the World Health Organization Composite International Diagnostic Interview (WHO CIDI). Results Results showed that temperament at age 11 predicted future mental disorders, thereby providing support for the vulnerability model. Moreover, temperament change predicted future mental disorders above and beyond the effect of basal temperament. For example, an increase in frustration increased the risk of mental disorders proportionally. Conclusion This study confirms, and extends, the vulnerability model. Consequences of both temperament and temperament change were general (e.g., changes in frustration predicted both internalizing and externalizing disorders) as well as dimension specific (e.g., changes in fear predicted internalizing but not externalizing disorders). These findings confirm previous studies, which showed that mental disorders have both unique and shared underlying temperamental risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.12141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 [article] A test of the vulnerability model: temperament and temperament change as predictors of future mental disorders – the TRAILS study [Texte imprimé et/ou numérique] / Odilia M. LACEULLE, Auteur ; Johan ORMEL, Auteur ; Wilma A. M. VOLLEBERGH, Auteur ; Marcel A. G. VAN AKEN, Auteur ; Esther NEDERHOF, Auteur . - p.227-236. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-3 (March 2014) . - p.227-236 Mots-clés : Mental disorders  temperament traits  temperament change  vulnerability model Index. décimale : PER Périodiques Résumé : Background This study aimed to test the vulnerability model of the relationship between temperament and mental disorders using a large sample of adolescents from the TRacking Adolescents Individual Lives' Survey (TRAILS). The vulnerability model argues that particular temperaments can place individuals at risk for the development of mental health problems. Importantly, the model may imply that not only baseline temperament predicts mental health problems prospectively, but additionally, that changes in temperament predict corresponding changes in risk for mental health problems. Methods Data were used from 1195 TRAILS participants. Adolescent temperament was assessed both at age 11 and at age 16. Onset of mental disorders between age 16 and 19 was assessed at age 19, by means of the World Health Organization Composite International Diagnostic Interview (WHO CIDI). Results Results showed that temperament at age 11 predicted future mental disorders, thereby providing support for the vulnerability model. Moreover, temperament change predicted future mental disorders above and beyond the effect of basal temperament. For example, an increase in frustration increased the risk of mental disorders proportionally. Conclusion This study confirms, and extends, the vulnerability model. Consequences of both temperament and temperament change were general (e.g., changes in frustration predicted both internalizing and externalizing disorders) as well as dimension specific (e.g., changes in fear predicted internalizing but not externalizing disorders). These findings confirm previous studies, which showed that mental disorders have both unique and shared underlying temperamental risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.12141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226

---

1 (1 - 3 / 3)