Intrathecal Autologous Bone Marrow Mononuclear Cell Transplantation in a Case of Adult Autism / Alok SHARMA in Autism - Open Access, 3-2 (September 2013)  

Public ISBD [article]  inAutism - Open Access > 3-2 (September 2013) . - 5 p. Titre : Intrathecal Autologous Bone Marrow Mononuclear Cell Transplantation in a Case of Adult Autism Type de document : Texte imprimé et/ou numérique Auteurs : Alok SHARMA, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Hemangi SANE, Auteur ; Pooja KULKARNI, Auteur ; Nancy THOMAS, Auteur ; Amruta PARANJAPE, Auteur ; Prerna BADHE, Auteur Année de publication : 2013 Article en page(s) : 5 p. Langues : Anglais (eng) Mots-clés : Autism  Cellular therapy  Autologous  Bone marrow mononuclear cells  PET CT Index. décimale : PER Périodiques Résumé : Autism is a complex neurodevelopmental disorder with a worldwide prevalence of 1 in 88. With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathogenesis of autism. Recent findings of cellular therapy offering immunomodulatory, angigogenetic and paracrine effects make it a lucrative option for treatment of autism. We administered a 33 year old adult patient of autism intrathecally, with autologous bone marrow mononuclear cells (BMMNCs), twice with an interval of six months. On follow up at 3, 6 and 9 months post first intervention, he was re-evaluated clinically and no major or minor side effects were observed. At 6 and 9 months objective outcome measures of Indian Scale for Assessment of Autism (ISAA) and Clinical Global Impression (CGI) were used and they showed significant improvement. At the end of 9 months, on ISAA, the score improved from 94 to 64. The CGI showed improvement by change in severity of illness from 3 (Mildly ill) to 1 (Borderline mentally ill). Global improvement on CGI was scored 2 (much improved) with an efficacy index of 5 (moderate therapeutic effect). PET CT scan was repeated at 6 months which showed a balancing effect in the metabolism of affected areas. The changes observed on the PET CT scan correlated with clinical improvements. MRI remained same at 6 months thereby, indicating that PET CT scan may serve as a better monitoring tool for effects of cellular therapy. In this case study, we hypothesize that cellular therapy has repaired the neural connections and achieved balance in the excitatory and inhibitory neuronal cells by various mechanisms of neuroprotection, neuromodulation and neurorestoration. Cell therapy holds great potential and randomized controlled trials may be conducted to study their long term effects in treating autism. En ligne : http://dx.doi.org/10.4172/2165-7890.1000113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Intrathecal Autologous Bone Marrow Mononuclear Cell Transplantation in a Case of Adult Autism [Texte imprimé et/ou numérique] / Alok SHARMA, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Hemangi SANE, Auteur ; Pooja KULKARNI, Auteur ; Nancy THOMAS, Auteur ; Amruta PARANJAPE, Auteur ; Prerna BADHE, Auteur . - 2013 . - 5 p. Langues : Anglais (eng) in Autism - Open Access > 3-2 (September 2013) . - 5 p. Mots-clés : Autism  Cellular therapy  Autologous  Bone marrow mononuclear cells  PET CT Index. décimale : PER Périodiques Résumé : Autism is a complex neurodevelopmental disorder with a worldwide prevalence of 1 in 88. With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathogenesis of autism. Recent findings of cellular therapy offering immunomodulatory, angigogenetic and paracrine effects make it a lucrative option for treatment of autism. We administered a 33 year old adult patient of autism intrathecally, with autologous bone marrow mononuclear cells (BMMNCs), twice with an interval of six months. On follow up at 3, 6 and 9 months post first intervention, he was re-evaluated clinically and no major or minor side effects were observed. At 6 and 9 months objective outcome measures of Indian Scale for Assessment of Autism (ISAA) and Clinical Global Impression (CGI) were used and they showed significant improvement. At the end of 9 months, on ISAA, the score improved from 94 to 64. The CGI showed improvement by change in severity of illness from 3 (Mildly ill) to 1 (Borderline mentally ill). Global improvement on CGI was scored 2 (much improved) with an efficacy index of 5 (moderate therapeutic effect). PET CT scan was repeated at 6 months which showed a balancing effect in the metabolism of affected areas. The changes observed on the PET CT scan correlated with clinical improvements. MRI remained same at 6 months thereby, indicating that PET CT scan may serve as a better monitoring tool for effects of cellular therapy. In this case study, we hypothesize that cellular therapy has repaired the neural connections and achieved balance in the excitatory and inhibitory neuronal cells by various mechanisms of neuroprotection, neuromodulation and neurorestoration. Cell therapy holds great potential and randomized controlled trials may be conducted to study their long term effects in treating autism. En ligne : http://dx.doi.org/10.4172/2165-7890.1000113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report / Alok SHARMA in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 6 p. Titre : PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report Type de document : Texte imprimé et/ou numérique Auteurs : Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism  Stem cell therapy  Bone marrow mononuclear cells  Autologous  Childhood autism Rating scale  Functional neuroimaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report [Texte imprimé et/ou numérique] / Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 6 p. Mots-clés : Autism  Stem cell therapy  Bone marrow mononuclear cells  Autologous  Childhood autism Rating scale  Functional neuroimaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

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