[article]
| Titre : |
Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Hendrik WESSELING, Auteur ; Paul C. GUEST, Auteur ; Chi-Ming LEE, Auteur ; Erik HF WONG, Auteur ; Hassan RAHMOUNE, Auteur ; Sabine BAHN, Auteur |
| Article en page(s) : |
p.1-17 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Over the last decade, the transgenic N-methyl-D-aspartate receptor (NMDAR) NR1-knockdown mouse (NR1neo?/?) has been investigated as a glutamate hypofunction model for schizophrenia. Recent research has now revealed that the model also recapitulates cognitive and negative symptoms in the continuum of other psychiatric diseases, particularly autism spectrum disorders (ASD). As previous studies have mostly focussed on behavioural readouts, a molecular characterisation of this model will help to identify novel biomarkers or potential drug targets. |
| En ligne : |
http://dx.doi.org/10.1186/2040-2392-5-38 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 |
in Molecular Autism > (July 2014) . - p.1-17
[article] Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders [Texte imprimé et/ou numérique] / Hendrik WESSELING, Auteur ; Paul C. GUEST, Auteur ; Chi-Ming LEE, Auteur ; Erik HF WONG, Auteur ; Hassan RAHMOUNE, Auteur ; Sabine BAHN, Auteur . - p.1-17. Langues : Anglais ( eng) in Molecular Autism > (July 2014) . - p.1-17
| Index. décimale : |
PER Périodiques |
| Résumé : |
Over the last decade, the transgenic N-methyl-D-aspartate receptor (NMDAR) NR1-knockdown mouse (NR1neo?/?) has been investigated as a glutamate hypofunction model for schizophrenia. Recent research has now revealed that the model also recapitulates cognitive and negative symptoms in the continuum of other psychiatric diseases, particularly autism spectrum disorders (ASD). As previous studies have mostly focussed on behavioural readouts, a molecular characterisation of this model will help to identify novel biomarkers or potential drug targets. |
| En ligne : |
http://dx.doi.org/10.1186/2040-2392-5-38 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 |
|
Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders in Molecular Autism, (July 2014)
