[article]
| Titre : |
NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur |
| Article en page(s) : |
p.1-12 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-015-0023-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 |
in Molecular Autism > (May 2015) . - p.1-12
[article] NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder [Texte imprimé et/ou numérique] / Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur . - p.1-12. Langues : Anglais ( eng) in Molecular Autism > (May 2015) . - p.1-12
| Index. décimale : |
PER Périodiques |
| Résumé : |
The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-015-0023-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 |
|
NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder in Molecular Autism, (May 2015)
