[article] 
inDevelopment and Psychopathology > 28-1 (February 2016) . - p.225-237

Titre :	The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; Kelly S. BENKE, Auteur ; Brion MAHER, Auteur ; George UHL, Auteur ; Nicholas S. IALONGO, Auteur
Article en page(s) :	p.225-237
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence.
En ligne :	http://dx.doi.org/10.1017/S0954579415000401
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

[article] The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence [Texte imprimé et/ou numérique] / Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; Kelly S. BENKE, Auteur ; Brion MAHER, Auteur ; George UHL, Auteur ; Nicholas S. IALONGO, Auteur . - p.225-237.
Langues : Anglais (eng)
in Development and Psychopathology > 28-1 (February 2016) . - p.225-237

Index. décimale :	PER Périodiques
Résumé :	Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence.
En ligne :	http://dx.doi.org/10.1017/S0954579415000401
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278