[article]
| Titre : |
Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children |
| Type de document : |
texte imprimé |
| Auteurs : |
Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R. H. BEACH, Auteur ; Tianyi YU, Auteur |
| Article en page(s) : |
p.415-431 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. |
| En ligne : |
http://dx.doi.org/10.1017/S095457941500053X |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 |
in Development and Psychopathology > 28-2 (May 2016) . - p.415-431
[article] Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children [texte imprimé] / Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R. H. BEACH, Auteur ; Tianyi YU, Auteur . - p.415-431. Langues : Anglais ( eng) in Development and Psychopathology > 28-2 (May 2016) . - p.415-431
| Index. décimale : |
PER Périodiques |
| Résumé : |
This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. |
| En ligne : |
http://dx.doi.org/10.1017/S095457941500053X |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 |
|  |
Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children in Development and Psychopathology, 28-2 (May 2016)
