Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers / Kathryn K. RIDOUT in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1277-1287 Titre : Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur ; Ronald SEIFER, Auteur ; Lawrence H. PRICE, Auteur ; Joel GELERNTER, Auteur ; Paloma FELIZ, Auteur ; Audrey R. TYRKA, Auteur Année de publication : 2014 Article en page(s) : p.1277-1287 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Evidence now implicates inflammatory proteins in the neurobiology of internalizing disorders. Genetic factors may influence individual responses to maltreatment; however, little work has examined inflammatory genetic variants in adults and none in children. The present study examined the role of an interleukin 1B gene (IL1B) variant in preschoolers exposed to maltreatment and other forms of adversity in internalizing symptom development. One hundred ninety-eight families were enrolled, with one child (age 3–5 years) from each family. Adversity measures included child protective service documentation of moderate–severe maltreatment in the last 6 months and interview-assessed contextual stressors. Internalizing symptoms were measured using the Child Behavior Checklist and the Diagnostic Infant and Preschool Assessment. Maltreated children had higher major depressive disorder (MDD) and posttraumatic stress disorder symptoms and marginally higher internalizing symptoms on the Child Behavior Checklist. Controlling for age, sex, and race, IL1B genotype was associated with MDD symptoms (p = .002). Contextual stressors were significantly associated with MDD and posttraumatic stress disorder and marginally with internalizing symptoms. The IL1B genotype interacted with contextual stress such that children homozygous for the minor allele had more MDD symptoms (p = .045). These results suggest that genetic variants of IL1B may modulate the development of internalizing symptoms in the face of childhood adversity. En ligne : http://dx.doi.org/10.1017/S0954579414001023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers [Texte imprimé et/ou numérique] / Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur ; Ronald SEIFER, Auteur ; Lawrence H. PRICE, Auteur ; Joel GELERNTER, Auteur ; Paloma FELIZ, Auteur ; Audrey R. TYRKA, Auteur . - 2014 . - p.1277-1287. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1277-1287 Index. décimale : PER Périodiques Résumé : Evidence now implicates inflammatory proteins in the neurobiology of internalizing disorders. Genetic factors may influence individual responses to maltreatment; however, little work has examined inflammatory genetic variants in adults and none in children. The present study examined the role of an interleukin 1B gene (IL1B) variant in preschoolers exposed to maltreatment and other forms of adversity in internalizing symptom development. One hundred ninety-eight families were enrolled, with one child (age 3–5 years) from each family. Adversity measures included child protective service documentation of moderate–severe maltreatment in the last 6 months and interview-assessed contextual stressors. Internalizing symptoms were measured using the Child Behavior Checklist and the Diagnostic Infant and Preschool Assessment. Maltreated children had higher major depressive disorder (MDD) and posttraumatic stress disorder symptoms and marginally higher internalizing symptoms on the Child Behavior Checklist. Controlling for age, sex, and race, IL1B genotype was associated with MDD symptoms (p = .002). Contextual stressors were significantly associated with MDD and posttraumatic stress disorder and marginally with internalizing symptoms. The IL1B genotype interacted with contextual stress such that children homozygous for the minor allele had more MDD symptoms (p = .045). These results suggest that genetic variants of IL1B may modulate the development of internalizing symptoms in the face of childhood adversity. En ligne : http://dx.doi.org/10.1017/S0954579414001023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

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