Developmental mediation of genetic variation in response to the Fast Track prevention program / Dustin ALBERT in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.81-95 Titre : Developmental mediation of genetic variation in response to the Fast Track prevention program Type de document : Texte imprimé et/ou numérique Auteurs : Dustin ALBERT, Auteur ; Daniel W. BELSKY, Auteur ; D. Max CROWLEY, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; Jennifer E. LANSFORD, Auteur ; Danielle DICK, Auteur ; Kenneth A. DODGE, Auteur Article en page(s) : p.81-95 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention. En ligne : http://dx.doi.org/10.1017/S095457941400131X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Developmental mediation of genetic variation in response to the Fast Track prevention program [Texte imprimé et/ou numérique] / Dustin ALBERT, Auteur ; Daniel W. BELSKY, Auteur ; D. Max CROWLEY, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; Jennifer E. LANSFORD, Auteur ; Danielle DICK, Auteur ; Kenneth A. DODGE, Auteur . - p.81-95. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.81-95 Index. décimale : PER Périodiques Résumé : We conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention. En ligne : http://dx.doi.org/10.1017/S095457941400131X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Kindergarten conduct problems are associated with monetized outcomes in adolescence and adulthood / Yoon S. HUR ; Damon E. JONES ; Jennifer GODWIN ; Robert J. MCMAHON ; Kenneth A. DODGE ; Jennifer E. LANSFORD ; John E. LOCHMAN ; John E. BATES ; Gregory S. PETTIT ; D. Max CROWLEY in Journal of Child Psychology and Psychiatry, 65-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.328-339 Titre : Kindergarten conduct problems are associated with monetized outcomes in adolescence and adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Yoon S. HUR, Auteur ; Damon E. JONES, Auteur ; Jennifer GODWIN, Auteur ; Robert J. MCMAHON, Auteur ; Kenneth A. DODGE, Auteur ; Jennifer E. LANSFORD, Auteur ; John E. LOCHMAN, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; D. Max CROWLEY, Auteur Article en page(s) : p.328-339 Index. décimale : PER Périodiques Résumé : Background Across several sites in the United States, we examined whether kindergarten conduct problems among mostly population-representative samples of children were associated with increased criminal and related (criminal?+?lost offender productivity?+?victim; described as criminal?+?victim hereafter) costs across adolescence and adulthood, as well as government and medical services costs in adulthood. Methods Participants (N?=?1,339) were from two multisite longitudinal studies: Fast Track (n?=?754) and the Child Development Project (n?=?585). Parents and teachers reported on kindergarten conduct problems, administrative and national database records yielded indexes of criminal offending, and participants self-reported their government and medical service use. Outcomes were assigned costs, and significant associations were adjusted for inflation to determine USD 2020 costs. Results A 1SD increase in kindergarten conduct problems was associated with a $21,934 increase in adolescent criminal + victim costs, a $63,998 increase in adult criminal?+?victim costs, a $12,753 increase in medical services costs, and a $146,279 increase in total costs. In the male sample, a 1SD increase in kindergarten conduct problems was associated with a $28,530 increase in adolescent criminal + victim costs, a $58,872 increase in adult criminal?+?victim costs, and a $144,140 increase in total costs. In the female sample, a 1SD increase in kindergarten conduct problems was associated with a $15,481 increase in adolescent criminal?+?victim costs, a $62,916 increase in adult criminal?+?victim costs, a $24,105 increase in medical services costs, and a $144,823 increase in total costs. Conclusions This investigation provides evidence of the long-term costs associated with early-starting conduct problems, which is important information that can be used by policymakers to support research and programs investing in a strong start for children. En ligne : https://doi.org/10.1111/jcpp.13837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] Kindergarten conduct problems are associated with monetized outcomes in adolescence and adulthood [Texte imprimé et/ou numérique] / Yoon S. HUR, Auteur ; Damon E. JONES, Auteur ; Jennifer GODWIN, Auteur ; Robert J. MCMAHON, Auteur ; Kenneth A. DODGE, Auteur ; Jennifer E. LANSFORD, Auteur ; John E. LOCHMAN, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; D. Max CROWLEY, Auteur . - p.328-339. in Journal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.328-339 Index. décimale : PER Périodiques Résumé : Background Across several sites in the United States, we examined whether kindergarten conduct problems among mostly population-representative samples of children were associated with increased criminal and related (criminal?+?lost offender productivity?+?victim; described as criminal?+?victim hereafter) costs across adolescence and adulthood, as well as government and medical services costs in adulthood. Methods Participants (N?=?1,339) were from two multisite longitudinal studies: Fast Track (n?=?754) and the Child Development Project (n?=?585). Parents and teachers reported on kindergarten conduct problems, administrative and national database records yielded indexes of criminal offending, and participants self-reported their government and medical service use. Outcomes were assigned costs, and significant associations were adjusted for inflation to determine USD 2020 costs. Results A 1SD increase in kindergarten conduct problems was associated with a $21,934 increase in adolescent criminal + victim costs, a $63,998 increase in adult criminal?+?victim costs, a $12,753 increase in medical services costs, and a $146,279 increase in total costs. In the male sample, a 1SD increase in kindergarten conduct problems was associated with a $28,530 increase in adolescent criminal + victim costs, a $58,872 increase in adult criminal?+?victim costs, and a $144,140 increase in total costs. In the female sample, a 1SD increase in kindergarten conduct problems was associated with a $15,481 increase in adolescent criminal?+?victim costs, a $62,916 increase in adult criminal?+?victim costs, a $24,105 increase in medical services costs, and a $144,823 increase in total costs. Conclusions This investigation provides evidence of the long-term costs associated with early-starting conduct problems, which is important information that can be used by policymakers to support research and programs investing in a strong start for children. En ligne : https://doi.org/10.1111/jcpp.13837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

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