Adversity in preschool-aged children: Effects on salivary interleukin-1? / Audrey R. TYRKA in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.567-576 Titre : Adversity in preschool-aged children: Effects on salivary interleukin-1? Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Thomas R. VALENTINE, Auteur ; Nicole M. ESLINGER, Auteur ; Ronald SEIFER, Auteur Article en page(s) : p.567-576 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Exposure to early life adversity is linked to impaired affective, cognitive, and behavioral functioning and increases risk for various psychiatric and medical conditions. Stress-induced increases in pro-inflammatory cytokines may be a biological mechanism of these effects. Few studies have examined cytokine levels in children experiencing early life adversity, and very little research has investigated cytokines or other markers of inflammation in saliva. In the present study, we examined salivary interleukin (IL)-1? and C-reactive protein (CRP) levels in relation to stress exposure in 40 children aged 3 to 5 years who were enrolled in a larger study of early life adversity. Childhood maltreatment status was assessed via review of child welfare records. Contextual stress exposure, traumatic life event history, and symptoms of psychopathology were assessed via caregiver interviews at a home visit. In a subsequent visit, salivary IL-1? and CRP were obtained before and after participation in four emotion-eliciting tasks. The number of past-month contextual stressors, lifetime contextual stressors, and traumatic life events each demonstrated a significant main effect on IL-1?. Baseline IL-1? was positively associated with each of the significant main-effect adversities. Postchallenge IL-1? displayed positive associations with each adversity variable, but these were not significant. CRP was not significantly associated with any of the adversity variables. Given the evidence suggesting the involvement of IL-1? in the neuropathology of psychiatric conditions, these results may have important implications for developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579415000164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Adversity in preschool-aged children: Effects on salivary interleukin-1? [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Thomas R. VALENTINE, Auteur ; Nicole M. ESLINGER, Auteur ; Ronald SEIFER, Auteur . - p.567-576. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.567-576 Index. décimale : PER Périodiques Résumé : Exposure to early life adversity is linked to impaired affective, cognitive, and behavioral functioning and increases risk for various psychiatric and medical conditions. Stress-induced increases in pro-inflammatory cytokines may be a biological mechanism of these effects. Few studies have examined cytokine levels in children experiencing early life adversity, and very little research has investigated cytokines or other markers of inflammation in saliva. In the present study, we examined salivary interleukin (IL)-1? and C-reactive protein (CRP) levels in relation to stress exposure in 40 children aged 3 to 5 years who were enrolled in a larger study of early life adversity. Childhood maltreatment status was assessed via review of child welfare records. Contextual stress exposure, traumatic life event history, and symptoms of psychopathology were assessed via caregiver interviews at a home visit. In a subsequent visit, salivary IL-1? and CRP were obtained before and after participation in four emotion-eliciting tasks. The number of past-month contextual stressors, lifetime contextual stressors, and traumatic life events each demonstrated a significant main effect on IL-1?. Baseline IL-1? was positively associated with each of the significant main-effect adversities. Postchallenge IL-1? displayed positive associations with each adversity variable, but these were not significant. CRP was not significantly associated with any of the adversity variables. Given the evidence suggesting the involvement of IL-1? in the neuropathology of psychiatric conditions, these results may have important implications for developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579415000164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children / Audrey R. TYRKA in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.577-585 Titre : Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Nicole M. ESLINGER, Auteur ; Carmen J. MARSIT, Auteur ; Corina LESSEUR, Auteur ; David A. ARMSTRONG, Auteur ; Noah S. PHILIP, Auteur ; Brittney JOSEFSON, Auteur ; Ronald SEIFER, Auteur Article en page(s) : p.577-585 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Epigenetic modifications to the genome are a key mechanism involved in the biological encoding of experience. Animal studies and a growing body of literature in humans have shown that early adversity is linked to methylation of the gene for the glucocorticoid receptor (GR), which is a key regulator of the hypothalamic–pituitary–adrenal axis as well as a broad range of physiological systems including metabolic and immune function. One hundred eighty-four families participated, including n = 74 with child welfare documentation of moderate-severe maltreatment in the past 6 months. Children ranged in age from 3 to 5 years, and were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors, and a composite variable assessed the number exposures to these adversities. Methylation of regions 1D, 1F, and 1H of the GR gene was measured via sodium bisulfite pyrosequencing. The composite measure of adversity was positively correlated with methylation at exons 1D and 1F in the promoter of the GR gene. Individual stress measures were significantly associated with a several CpG sites in these regions. GR gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children. En ligne : http://dx.doi.org/10.1017/S0954579415000176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Nicole M. ESLINGER, Auteur ; Carmen J. MARSIT, Auteur ; Corina LESSEUR, Auteur ; David A. ARMSTRONG, Auteur ; Noah S. PHILIP, Auteur ; Brittney JOSEFSON, Auteur ; Ronald SEIFER, Auteur . - p.577-585. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.577-585 Index. décimale : PER Périodiques Résumé : Epigenetic modifications to the genome are a key mechanism involved in the biological encoding of experience. Animal studies and a growing body of literature in humans have shown that early adversity is linked to methylation of the gene for the glucocorticoid receptor (GR), which is a key regulator of the hypothalamic–pituitary–adrenal axis as well as a broad range of physiological systems including metabolic and immune function. One hundred eighty-four families participated, including n = 74 with child welfare documentation of moderate-severe maltreatment in the past 6 months. Children ranged in age from 3 to 5 years, and were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors, and a composite variable assessed the number exposures to these adversities. Methylation of regions 1D, 1F, and 1H of the GR gene was measured via sodium bisulfite pyrosequencing. The composite measure of adversity was positively correlated with methylation at exons 1D and 1F in the promoter of the GR gene. Individual stress measures were significantly associated with a several CpG sites in these regions. GR gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children. En ligne : http://dx.doi.org/10.1017/S0954579415000176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

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