Oculomotor executive function abnormalities with increased tic severity in Tourette syndrome / Cameron B. JETER in Journal of Child Psychology and Psychiatry, 56-2 (February 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-2 (February 2015) . - p.193-202 Titre : Oculomotor executive function abnormalities with increased tic severity in Tourette syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Cameron B. JETER, Auteur ; Saumil S. PATEL, Auteur ; Jeffrey S. MORRIS, Auteur ; Alice Z. CHUANG, Auteur ; Ian J. BUTLER, Auteur ; Anne B. SERENO, Auteur Article en page(s) : p.193-202 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder  cognitive control  executive function  n-back  obsessive-compulsive disorder  saccades Index. décimale : PER Périodiques Résumé : Background Reports conflict as to whether Tourette syndrome (TS) confers deficits in executive function. This study's aim was to evaluate executive function in youths with TS using oculomotor tasks while controlling for confounds of tic severity, age, medication, and severity of comorbid disorders. Method Four saccade tasks requiring the executive functions of response generation, response inhibition, and working memory (prosaccade, antisaccade, 0-back, and 1-back) were administered. Twenty youths with TS and low tic severity (TS-low), nineteen with TS and moderate tic severity (TS-moderate), and 29 typically developing control subjects (Controls) completed the oculomotor tasks. Results There were small differences across groups in the prosaccade task. Controlling for any small sensorimotor differences, TS-moderate subjects had significantly higher error rates than Controls and TS-low subjects in the 0-back and 1-back tasks. In the 1-back task, these patients also took longer to respond than Controls or TS-low subjects. Conclusions In a highly controlled design, the findings demonstrate for the first time that increased tic severity in TS is associated with impaired response inhibition and impaired working memory and that these executive function deficits cannot be accounted for by differences in age, medication or comorbid symptom severity. En ligne : http://dx.doi.org/10.1111/jcpp.12298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Oculomotor executive function abnormalities with increased tic severity in Tourette syndrome [Texte imprimé et/ou numérique] / Cameron B. JETER, Auteur ; Saumil S. PATEL, Auteur ; Jeffrey S. MORRIS, Auteur ; Alice Z. CHUANG, Auteur ; Ian J. BUTLER, Auteur ; Anne B. SERENO, Auteur . - p.193-202. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-2 (February 2015) . - p.193-202 Mots-clés : Attention deficit hyperactivity disorder  cognitive control  executive function  n-back  obsessive-compulsive disorder  saccades Index. décimale : PER Périodiques Résumé : Background Reports conflict as to whether Tourette syndrome (TS) confers deficits in executive function. This study's aim was to evaluate executive function in youths with TS using oculomotor tasks while controlling for confounds of tic severity, age, medication, and severity of comorbid disorders. Method Four saccade tasks requiring the executive functions of response generation, response inhibition, and working memory (prosaccade, antisaccade, 0-back, and 1-back) were administered. Twenty youths with TS and low tic severity (TS-low), nineteen with TS and moderate tic severity (TS-moderate), and 29 typically developing control subjects (Controls) completed the oculomotor tasks. Results There were small differences across groups in the prosaccade task. Controlling for any small sensorimotor differences, TS-moderate subjects had significantly higher error rates than Controls and TS-low subjects in the 0-back and 1-back tasks. In the 1-back task, these patients also took longer to respond than Controls or TS-low subjects. Conclusions In a highly controlled design, the findings demonstrate for the first time that increased tic severity in TS is associated with impaired response inhibition and impaired working memory and that these executive function deficits cannot be accounted for by differences in age, medication or comorbid symptom severity. En ligne : http://dx.doi.org/10.1111/jcpp.12298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

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